Simultaneous determination of propacetamol and paracetamol by derivative spectrophotometry

Ródenas, V.; García, M.S.; Sánchez‐Pedreño, Concepción; Albero, M.I.

doi:10.1016/s0039-9140(00)00397-0

Cited by 54 publications

(19 citation statements)

References 12 publications

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“…These results are not in accordance with the ones published by Ródenas et al 17) that reported a negligible hydrolysis of PRO in saline solution after 3 h and a 75.4% degradation in 5% glucose solution after 80 min of initiating the stability test. It should be noted that the authors of the latter paper did not take into consideration the influence that temperature has on the stability of PRO, which we have pointed out in our work.…”

Section: ϫ2contrasting

confidence: 99%

“…[15][16][17] The first-derivative spectrophotometric technique has the advantages of the speed, low cost, and environmental protection. The derivative methods circumvent the problem of overlapping spectral bands, allowing for the simultaneous determination of PRO and PA without prior separation, and providing accurate, precise, rapid, reproducible results.…”

Section: )mentioning

confidence: 99%

“…18,19) Standard Solutions The analytic technique used to determine quantitatively PRO and PA in the tests solutions was the first-derivative spectrophotometry. The method used was that proposed by Ródenas et al, 17) slightly modified by us to measure the amplitudes (nm) at 248.7 nm for PRO and 245.7 nm for PA.…”

Section: Influence Of Medium Andmentioning

confidence: 99%

“…15) This technique has been utilized to investigate the kinetics of drug degradation processes since it is an analytic tool that offers a convenient solution to a number of problems, especially its potential for increasing the detection sensitivity of minor spectral features. [15][16][17] The first-derivative spectrophotometric technique has the advantages of the speed, low cost, and environmental protection. The derivative methods circumvent the problem of overlapping spectral bands, allowing for the simultaneous determination of PRO and PA without prior separation, and providing accurate, precise, rapid, reproducible results.…”

mentioning

confidence: 99%

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Influence of Medium and Temperature on the Hydrolysis Kinetics of Propacetamol Hydrochloride: Determination Using Derivative Spectrophotometry

Barcia

Martín

Azuara

et al. 2005

CHEMICAL & PHARMACEUTICAL BULLETIN

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Paracetamol (acetaminophen; PA) is a poorly water-soluble analgesic that is widely used in hospital and ambulatory practice for the relief of mild to moderate pain associated with headache, backache, arthritis pain, and postoperative pain.1-3) It has been used in the treatment of pain in combination with aspirin, caffeine, opiates and/or other agents. Paracetamol also has antipyretic effects that do not differ significantly from those of aspirin, although it has only weak antiinflammatory effects. 4,5) Paracetamol is a step 1 agent in the analgesic ladder of WHO.6) During the advanced stages of cancer, nearly 75% of the patients have pain that is moderate or severe, and according to the WHO analgesic ladder, the first step is used for the treatment of mild to moderate pain starting with either NSAIDs or PA.In recommended therapeutic dosage regimens, PA is usually well tolerated. The most common side effect is lightheadedness. Skin rash and other allergic reactions occur occasionally. Overdoses of PA may cause nausea, vomiting, sweating, and exhaustion. The most serious adverse effect of acute overdosage is a dose-dependent, potentially fatal hepatic necrosis. 7)Due to its poor water solubility that prevents parenteral administration in a soluble form, the clinical indications for PA are limited, especially in the postoperative setting. Contrary to the latter, propacetamol hydrochloride [N-N-diethyl, 4-acetylamino) phenyl ester monohydrochloride] (PRO) is a water-soluble prodrug of paracetamol, which can be parenterally administered as analgesic 8,9) for the treatment of postoperative pain, acute trauma, and gastric and/or intestinal disorders where oral administration is not possible. PRO has also shown efficacy in the symptomatic control of fever in the fields of oncology, infectious disease, and hematology. [10][11][12][13] In these circumstances, PRO can be administered in physiologic or glucose solutions since it is rapidly and quantitatively hydrolyzed into PA by plasma estearases within 7 min after intravenous injection.8) With the exception of absorption, PRO exhibits similar disposition kinetics when given by either the intravenous route as PA or by mouth as conventional tablets. 14)Screening of the literature revealed that PRO can be analytically determined by first-derivative spectrophotometry. 15)This technique has been utilized to investigate the kinetics of drug degradation processes since it is an analytic tool that offers a convenient solution to a number of problems, especially its potential for increasing the detection sensitivity of minor spectral features. [15][16][17] The first-derivative spectrophotometric technique has the advantages of the speed, low cost, and environmental protection. The derivative methods circumvent the problem of overlapping spectral bands, allowing for the simultaneous determination of PRO and PA without prior separation, and providing accurate, precise, rapid, reproducible results. Therefore this was the analytic technique chosen for the present study.Since PRO is fr...

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Section: ϫ2contrasting

confidence: 99%

Section: )mentioning

confidence: 99%

Section: Influence Of Medium Andmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Influence of Medium and Temperature on the Hydrolysis Kinetics of Propacetamol Hydrochloride: Determination Using Derivative Spectrophotometry

Barcia

Martín

Azuara

et al. 2005

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Various methods have been studied for the single determination of DA or PAR, for example, in detecting DA, HPLC [10], as fluorometry [11], UV-vis [12], and, in detecting PAR, spectrophotometry [13][14][15][16][17], near infrared transmittance spectroscopy [18], Fourier transform infrared spectrophotometry [19], spectrofluorometry [20,21], and chromatography [22,23]. However, the majority of these methods suffer from some disadvantages such as high costs, long analysis times, and requirement for sample pretreatment, and in some cases low sensitivity and selectivity that makes them unsuitable for routine analysis.…”

Section: Introductionmentioning

confidence: 99%

Development of a Method for a Sensitive Simultaneous Determination of Dopamine and Paracetamol in Biological Samples and Pharmaceutical Preparations

Babaei

Dehdashti

Afrasiabi

2011

International Journal of Electrochemistry

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A chemically modified electrode is constructed based on multiwalled carbon nanotube-modified glassy carbon electrode (MWCNTs/GCE). The measurements were carried out by application of differential pulse voltammetry (DPV), cyclic voltammetry (CV), and chronoamperometry (CA) methods. Application of DPV method showed wide linear range of DA from 1 μM to 540 μM and a detection limit of 0.098 μM (S/N = 3). The linear range of PAR of 3 μM to 300 μM and a detection limit of 0.15 μM, were obtained. The modified electrode showed electrochemical responses with high sensitivity, high selectivity, and excellent stability for DA and PAR determination at optimal conditions, which makes it a suitable sensor for simultaneous submicromolar detection of DA and PAR in solutions. The analytical performance of this sensor has been evaluated for detection of DA and PAR in human serum, human urine, and pharmaceutical preparation with satisfactory results.

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A Sensitive Simultaneous Determination of Adrenalin and Paracetamol on a Glassy Carbon Electrode Coated with a Film of Chitosan/Room Temperature Ionic Liquid/Single‐Walled Carbon Nanotubes Nanocomposite

2011

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The present work demonstrates that simultaneous determination of adrenalin (AD) and paracetamol (PAR) can be performed on single-walled carbon nanotube/chitosan/ionic liquid modified glassy carbon electrode (SWCNT-CHIT-IL/GCE). The electro-oxidations of AD and PAR were investigated with cyclic voltammetry (CV), differential pulse voltammetry (DPV) and also chronoamperometry (CA) methods. DPV experiments showed that the oxidation peak currents of AD and PAR are proportional to the corresponding concentrations over the 1-580 µmol/L and 0.5-400 µmol/L ranges, respectively. The RSD at a concentration level of 15 µmol/L AD and 15 µmol/L PAR were 1.69% and 1.82%, respectively. Finally the modified electrode was used for simultaneous determination of AD and PAR in real samples with satisfactory results.

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Simultaneous determination of propacetamol and paracetamol by derivative spectrophotometry

Cited by 54 publications

References 12 publications

Influence of Medium and Temperature on the Hydrolysis Kinetics of Propacetamol Hydrochloride: Determination Using Derivative Spectrophotometry

Influence of Medium and Temperature on the Hydrolysis Kinetics of Propacetamol Hydrochloride: Determination Using Derivative Spectrophotometry

Development of a Method for a Sensitive Simultaneous Determination of Dopamine and Paracetamol in Biological Samples and Pharmaceutical Preparations

A Sensitive Simultaneous Determination of Adrenalin and Paracetamol on a Glassy Carbon Electrode Coated with a Film of Chitosan/Room Temperature Ionic Liquid/Single‐Walled Carbon Nanotubes Nanocomposite

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