Simultaneous determination of potassium guaiacolsulfonate, guaifenesin, diphenhydramine HCl and carbetapentane citrate in syrups by using HPLC-DAD coupled with partial least squares multivariate calibration

Dönmez, Özlem Aksu; Aşçı, Bürge; Bozdoğan, Abdürrezzak; Sungur, Sıdıka

doi:10.1016/j.talanta.2010.11.054

Cited by 32 publications

(14 citation statements)

References 36 publications

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“…1,4,24,25 We have demonstrated that caramiphen has a local anesthetic effect on spinal anesthesia. 5 Infiltrative cutaneous anesthesia is an acceptable choice for the management of surgical anesthesia and postoperative pain, because it is relatively free of adverse effects.…”

Section: Discussionmentioning

confidence: 99%

“…1 Another known nonopioid antitussive, caramiphen, was first introduced into therapy for diseases of the basal ganglia 2 and has been available as an antitussive agent in Europe since 1950. 3 Recently, it has been shown that the antagonism of N-methyl-D-aspartate receptor activation and the facilitation of GABA A receptor activation by caramiphen in the basolateral amygdala may play an important role in the anticonvulsive and neuroprotective properties of caramiphen.…”

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confidence: 99%

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Cutaneous Analgesia and Systemic Toxicity of Carbetapentane and Caramiphen in Rats

Hung¹,

Chu

Chen

et al. 2012

Regional Anesthesia and Pain Medicine

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Cutaneous Analgesia and Systemic Toxicity of Carbetapentane and Caramiphen in Rats

Hung¹,

Chu

Chen

et al. 2012

Regional Anesthesia and Pain Medicine

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“…This leads to the increase of vascular smooth muscle contraction, so reducing the redness, hyperthermia and edema that occur during an inflammatory reaction. Several techniques were published for the estimation of DPH in pharmaceutical formulations and in biological fluids including: spectrophotometry [2-5], potentiometric [6], high performance liquid chromatography [7,8], liquid chromatography [9] and capillary electrophoresis [10,11].…”

Section: Introductionmentioning

confidence: 99%

Charge-transfer interaction between antihistamine antiallergic drugs, diphenhydramine, fexofenadine, cetirizine and two π-acceptors in pharmaceutical forms

El‐Didamony

Ramadan²

2020

SN Appl. Sci.

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Two simple and sensitive spectrophotometric techniques have been proposed for the estimation of antihistamine drugs, diphenhydramine hydrochloride (DPH), fexofenadine hydrochloride (FXO) and cetirizine dihydrochloride (CTZ) in pure forms and in their pharmaceutical forms via charge-transfer complex formation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) reagents. Spectrophotometric methods involve the addition a known excess of DDQ or TCNQ reagents to DPH, FXO and CTZ drugs in acetonitrile, followed by the measurement of the absorbance of formed CT complexes at the selected wavelength. Various variables and parameters affecting the reactions were studied and investigated. Beer's law was obeyed in the concentration ranges of 16-144, 12-120, 12-86 μg mL −1 and 6-66, 24-216 and 4-68 μg mL −1 for DPH, FXO and CTZ drugs using DDQ and TCNQ reagents, respectively, with correlation coefficients not less than 0.9944. The reaction stoichiometry is found to be 1:1 [drug]: [DDQ or TCNQ]. For the spectrophotometric methods, molar absorptivity, detection and quantification limits, and sandell resistance are also calculated. According to ICH guidelines, both intra-and inter-day precision and reliability were evaluated. The estimated techniques have been successfully applied in their medicinal forms to the determination of the cited drugs. The finding showed no significant difference between the estimated methods and reported methods, depended on t test and variance ratio. Popular pharmaceutical additives did not interfere.

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“…Several methods have been reported for determination of diphenhydramine hydrochloride in pharmaceutical formulations including spectrophotometry [3][4][5][6][7][8][9][10], flow injection spectrophotometry [11,12], atomic absorption spectrometry [13][14][15][16], potentiometry with selective membrane electrode [17][18][19], non-aqueous potentiometric titration [20], amperometry [21], capillary electrophoresis [22][23][24][25][26] and conductometric titration using silver nitrate as a titrant [27]. Chromatographic methods have been used for the determination of diphenhydramine hydrochloride with other ingredients in combined formulations including high performance liquid chromatography with UV detection [28][29][30][31][32][33][34][35][36], indirect conductometric detection [37], gas chromatography [38][39][40][41][42] and high-performance thin layer chromatography [43,44]. The drug and its formulations are official in British Pharmacopoeia [45], which recommended HPLC for its assay.…”

Section: Introductionmentioning

confidence: 99%

New Conductometric Titration Methods for Determination of Diphenhydramine Hydrochloride Using Sodium Tetraphenylborate and Cetylpyridinium Bromide

Ashour¹

2018

IJPC

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Sodium tetraphenylborate (TPB) and cetylpyridinium bromide (CPB) were used as titrant for the conductometric determination of diphenhydramine hydrochloride (DPH) drug through ion association complex formation and then the conductance of the solution is measured as a function of the volume of titrant. The effect of the solvent, reagent concentration, temperature and molar combining ratio of the formed ion-associates were studied and evaluated. The suggested method was applied for the determination of diphenhydramine hydrochloride in pure form and pharmaceutical preparations. The described procedures allowed the determination of the studied drug in bi-distilled water in the range of 0.75-16 mg. Statistical treatment of the experimental results indicates that the method is precise and accurate. The accuracy of the method was indicated by excellent recovery and the precision supported by the low relative standard deviation <1%. The sensitivity of the proposed method was discussed and the results were compared with the potentiometric pharmacopoeial method. The proposed procedure was simple, precise and low cost and can be applied for the routine measurements of the cited drug.

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Simultaneous determination of potassium guaiacolsulfonate, guaifenesin, diphenhydramine HCl and carbetapentane citrate in syrups by using HPLC-DAD coupled with partial least squares multivariate calibration

Cited by 32 publications

References 36 publications

Cutaneous Analgesia and Systemic Toxicity of Carbetapentane and Caramiphen in Rats

Cutaneous Analgesia and Systemic Toxicity of Carbetapentane and Caramiphen in Rats

Charge-transfer interaction between antihistamine antiallergic drugs, diphenhydramine, fexofenadine, cetirizine and two π-acceptors in pharmaceutical forms

New Conductometric Titration Methods for Determination of Diphenhydramine Hydrochloride Using Sodium Tetraphenylborate and Cetylpyridinium Bromide

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