Simultaneous determination of pirprofen and its metabolite, the pyrrole derivative, in plasma by high-performance liquid chromatography

Colussi, D.; Marfil, F.; Sioufi, A.

doi:10.1016/s0378-4347(00)84637-x

Cited by 7 publications

(1 citation statement)

References 2 publications

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“…The concentrations of pirprofen and its pyrrole metabolite were simultaneously detemlined by high performance liquid chromatography (5). Method validation was perfonned by analysing plasma samples spiked with pirprofen and its pyrrole metabolite.…”

Section: Analytical Proceduresmentioning

confidence: 99%

Pharmacokinetics of pirprofen in children with juvenile chronic arthritis

Hallé

Marfil²,

Sioufi³

et al. 1991

European Journal of Drug Metabolism and Pharmacokinetics

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Pirprofen (100 or 200 mg; Rengasil) was administered to experimental groups of children (children with juvenile chronic arthritis, JCA) and to a control group of children (children without JCA) as a single dose or as repeated doses. The pharmacokinetics of pirprofen in these children were compared to the pharmacokinetic parameter values obtained in healthy volunteers and in elderly arthritic adults receiving 400 mg of pirprofen. The children were examined regularly and laboratory values were determined in order to detect possible side effects. The results demonstrated that the pharmacokinetics of pirprofen were similar for children and adults when taking into account the dose and the body weight. There was no drug accumulation after repeated administration of pirprofen. As already observed in rheumatic adults, pirprofen remains in synovial fluid longer than in plasma.

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Section: Analytical Proceduresmentioning

confidence: 99%

Pharmacokinetics of pirprofen in children with juvenile chronic arthritis

Hallé

Marfil²,

Sioufi³

et al. 1991

European Journal of Drug Metabolism and Pharmacokinetics

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Analysis of Pirprofen in Cerebrospinal Fluid, Plasma. and Synovial FIuid by High-Performance Liquid Chromatography with Electrochemical Detection

Zecca

Ferrario

Pirola

et al. 1989

Journal of Pharmaceutical Sciences

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The diffusion of pirprofen into the cerebrospinal fluid in man

Zecca

Broggini²,

Pirola

et al. 1988

Eur J Clin Pharmacol

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We have measured the concentrations of pirprofen at various times in plasma and cerebrospinal fluid (CSF) samples, drawn during diagnostic myelography from 28 patients affected by sciatica. After intramuscular injection of 400 mg plasma concentrations of pirprofen reached a peak in 60 min then fell slowly. In contrast, the CSF concentration rose until 12 h and then fell. Pirprofen rapidly crossed the blood-brain barrier and was detectable in CSF at 15-30 min after injection. These results support the suggested hypothesis of a central analgesic action of pirprofen along with the known peripheral one. A new sensitive HPLC method was developed for measuring the concentration of pirprofen in the CSF.

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Simultaneous determination of pirprofen and its metabolite, the pyrrole derivative, in plasma by high-performance liquid chromatography

Cited by 7 publications

References 2 publications

Pharmacokinetics of pirprofen in children with juvenile chronic arthritis

Pharmacokinetics of pirprofen in children with juvenile chronic arthritis

Analysis of Pirprofen in Cerebrospinal Fluid, Plasma. and Synovial FIuid by High-Performance Liquid Chromatography with Electrochemical Detection

The diffusion of pirprofen into the cerebrospinal fluid in man

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