Simultaneous Determination of Paracetamol, Acetyl Salicylic Acid, Mefenamic Acid and Cetirizine Dihydrochloride in the Pharmaceutical Dosage Form

Havaldar, Freddy H.; Vairal, Dharmendra L.

doi:10.1155/2010/241876

Cited by 7 publications

(3 citation statements)

References 13 publications

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“…Capillary electrophoretic method has also been reported for simultaneous determination of Cetirizine dihydrochloride, Paracetamol and Phenylpropanolamine in tablets 18 . Similarly UV Spectrophotometric method 19,20 , HPLC method 21,22,23,24,25,26,27,28,29 , stability indicating HPLC method 30,31 , and some bioanalytical work by capillary electrophoresis 32 and HPLC 33 alone or in combination with other drugs is reported for Paracetamol.…”

Section: Figure 3 Structure Of Paracetamolmentioning

confidence: 93%

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2014

IJPSR

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A HPLC method has been described for simultaneous determination of Chlorpheniramine Maleate, Phenylpropanolamine Hydrochloride and Paracetamol in formulation. This method is based on HPLC separation of the three drugs on the Thermo Hypersil Gold C18 column (250mm ×4.6mm, 5.0µ), with isocratic conditions and mobile phase containing methanol: 0.01M disodium hydrogen phosphate dihydrate buffer pH 7 adjusted with Ortho Phosphoric Acid (OPA) (60: 40) at a flow rate of 1mL/min using UV detection at 217 nm. This method has been applied to formulation without interference of excipients of formulation. The linear regression analysis data for the calibration plots showed a good linear relationship over the concentration range of 0.5-3µg/mL for Chlorpheniramine Maleate, 7-12µg/mL for Phenylpropanolamine hydrochloride, and 0.4-1.4µg/mL for Paracetamol, respectively. The mean values of the correlation coefficient, slope and intercept were 0.

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Section: Figure 3 Structure Of Paracetamolmentioning

confidence: 93%

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2014

IJPSR

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“…The main analytical methods for the determination of PC, PZ, AS or CF are chromatographic analyses with different detectors [14][15][16][17]. These chromatographic methods are usually used for the detection of single or two analgesic-antipyretics drugs in pharmaceuticals [18][19][20][21]. Some chromatographic methods are found for the detection of AS or CF in different foods such as soft drinks, teas, fruits, vegetables, wines, spices, sauces and beverages [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of paracetamol, propyphenazone, aspirin and caffeine in white wine samples by liquid chromatography-triple quadrupole tandem mass spectrometry

Han

Ding

Peng

et al. 2023

Preprint

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A highly sensitive liquid chromatography-triple quadrupole tandem mass spectrometry (LC-MS/MS) for simultaneous determination of analgesic-antipyretics drugs, e.g. paracetamol (PC), propyphenazone (PZ), aspirin (AS) and caffeine (CF), in white wine samples was presented. The chromatographic separation was carried out on a narrow C18 column by a gradient elution using acetonitrile (A) and 10 mM ammonium acetate with 0.1% formic acid (B) as the solvents at a flow rate of 0.3 ml/min. Qualitative and quantitative analysis of PC, PZ and CF were achieved by multiple reaction monitoring (MRM) in positive mode, while the analysis of AS was completed by MRM in negative mode. Under optimal conditions, good linearity with high correlation coeﬃcient (>0.9981) were obtained between 0.05-50 ng mL-1 for PC, 0.005-20 g mL-1 for PZ, 0.3-200 g mL-1 for AS, and 1.0-50 g mL-1 for CF. The limit of detection (LOD) values of the method for PC, PZ, AS and CF were found to be 0.015, 0.0015, 0.08 and 0.25 g mL-1, respectively. Spiking experiments revealed good recoveries in range of 87.6~111.0% with relative standard deviations (RSD) of 2.1~9.4%. Total 1006 white wine samples were collected and analyzed by the proposed method. PC was found in three inferior white wines samples, and the residual levels of PC, PZ, AS and CF in other samples were undetectable. It was demonstrated that the proposed LC–MS/MS is a powerful analytical tool for sensitive determination of PC, PZ, AS and CF in white wine samples.

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“…Literature survey reveals some analytical methods are reported for simultaneous determination of paracetamol and cetirizine HCl by high-performance liquid chromatographic (HPLC) with isocratic elution [ 10 , 12 - 14 ], with gradient HPLC method [ 15 - 17 ] and capillary zone electrophoresis [ 18 ], paracetamol and parabens by HPLC [ 19 , 20 ], and the one and only method for CTZ with parabens (other than PP) [ 21 ], however our extensive research discloses that till now no stability indicating isocratic HPLC method is available which can determine the four ingredients concomitantly, therefore an endeavor was made to develop a simple, sensitive and validated stability indicating RP-HPLC method using UV detection to determine PCM and CTZ along with its essential microbial preservatives in liquid dosage forms and physiological fluid. Present work deals with method development, method validation and forced degradation study of the ingredients.…”

Section: Introductionmentioning

confidence: 99%

Development, Validation and Application of RP-HPLC Method: Simultaneous Determination of Antihistamine and Preservatives with Paracetamol in Liquid Formulations and Human Serum

Hasan¹,

Chaiharn²,

Toor³

et al. 2016

TOMCJ

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In this article we describe development and validation of stability indicating, accurate, specific, precise and simple Ion-pairing RP-HPLC method for simultaneous determination of paracetamol and cetirizine HCl along with preservatives i.e. propylparaben, and methylparaben in pharmaceutical dosage forms of oral solution and in serum. Acetonitrile: Buffer: Sulfuric Acid (45:55:0.3 v/v/v) was the mobile phase at flow rate 1.0 mL min-1 using a Hibar® Lichrosorb® C18 column and monitored at wavelength of 230nm. The averages of absolute and relative recoveries were found to be 99.3%, 99.5%, 99.8% and 98.7% with correlation coefficient of 0.9977, 0.9998, 0.9984, and 0.9997 for cetirizine HCl, paracetamol, methylparaben and Propylparaben respectively. The limit of quantification and limit of detection were in range of 0.3 to 2.7 ng mL-1 and 0.1 to 0.8 ng mL-1 respectively. Under stress conditions of acidic, basic, oxidative, and thermal degradation, maximum degradation was observed in basic and oxidative stress where a significant impact was observed while all drugs were found almost stable in the other conditions. The developed method was validated in accordance with ICH and AOAC guidelines. The proposed method was successfully applied to quantify amount of paracetamol, cetirizine HCl and two most common microbial preservatives in bulk, dosage form and physiological fluid.

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Simultaneous Determination of Paracetamol, Acetyl Salicylic Acid, Mefenamic Acid and Cetirizine Dihydrochloride in the Pharmaceutical Dosage Form

Cited by 7 publications

References 13 publications

Untitled

Untitled

Simultaneous determination of paracetamol, propyphenazone, aspirin and caffeine in white wine samples by liquid chromatography-triple quadrupole tandem mass spectrometry

Development, Validation and Application of RP-HPLC Method: Simultaneous Determination of Antihistamine and Preservatives with Paracetamol in Liquid Formulations and Human Serum

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