Simultaneous determination of non-steroidal anti-inflammatory drugs and natural estrogens in the mussels Mytilus edulis trossulus

Wolecki, Daniel; Caban, Magda; Pazdro, Ksenia; Mulkiewicz, Ewa; Stepnowski, Piotr; Kumirska, Jolanta

doi:10.1016/j.talanta.2019.03.062

Cited by 35 publications

(25 citation statements)

References 56 publications

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“…The extraction efficiencies of polar drugs: paracetamol (logP 0.46), terbutaline (logP 0.90), and nadolol (logP 0.81), decreased significantly where the ASE extracts obtained at 50 • C were subjected to acidification prior SPE ( Figure 2B). Similar results were observed in our previous study concerning the development of a method for determining NSAIDs and natural estrogens in the mussel Mytilus edulis trossulus [38]. In summary, based on the obtained results, the application of the mixture of MeOH:H 2 O (1:1, v/v) at 50 • C without the acidification of the ASE extract prior to SPE purification was chosen as the most optimal ASE-SPE conditions for the isolation of target compounds from plant material.…”

Section: Type Of Solvents/ Temperature/ Pharmaceuticalssupporting

confidence: 91%

Evaluation of the Possibility of Using Hydroponic Cultivations for the Removal of Pharmaceuticals and Endocrine Disrupting Compounds in Municipal Sewage Treatment Plants

et al. 2019

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The problem of the presence of pharmaceuticals and endocrine disrupting compounds (EDCs) in the environment is closely related to municipal wastewater and in consequence to municipal wastewater treatment plants (MWWTPs) because wastewater is the main way in which these compounds are transferred to the ecosystem. For this reason, the development of cheap, simple but very effective techniques for the removal of such residues from wastewater is very important. In this study, the analysis of the potential of using three new plants: Cyperus papyrus (Papyrus), Lysimachia nemorum (Yellow pimpernel), and Euonymus europaeus (European spindle) by hydroponic cultivation for the removal of 15 selected pharmaceuticals and endocrine disrupting compounds (EDCs) in an MWWTP is presented. In order to obtain the most reliable data, this study was performed using real WWTP conditions and with the determination of the selected analytes in untreated sewage, treated sewage, and in plant materials. For determining the target compounds in plant materials, an Accelerated Solvent Extraction (ASE)-Solid-Phase Extraction (SPE)-GC-MS(SIM) method was developed and validated. The obtained data proved that the elimination efficiency of the investigated substances from wastewater was in the range of 35.8% for diflunisal to above 99.9% for paracetamol, terbutaline, and flurbiprofen. Lysimachia nemorum was the most effective for the uptake of target compounds among the tested plant species. Thus, the application of constructed wetlands for supporting conventional MWWTPs allowed a significant increase in their removal from the wastewater stream.

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Section: Type Of Solvents/ Temperature/ Pharmaceuticalssupporting

confidence: 91%

Evaluation of the Possibility of Using Hydroponic Cultivations for the Removal of Pharmaceuticals and Endocrine Disrupting Compounds in Municipal Sewage Treatment Plants

et al. 2019

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“…To further evaluate the feasibility of the proposed method, determination of target EDCs in milk samples was performed. The spiking recoveries of EDCs were determined by adding the mixture of standard EDCs with concentrations of 1, 10 and 100 μg/L, and calculated based on Equation 40 :

normalR (() %) = \frac{C_{spiked} - C_{matrix}}{C_{standard}} \times 100 %

where C spiked , C matrix and C standard represent the concentrations of spiked, unspiked samples and standard solution, respectively.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of magnetic metal organic framework/covalent organic framework hybrid materials as adsorbents for magnetic solid‐phase extraction of four endocrine‐disrupting chemicals from milk samples

Yue

Liu

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale Endocrine‐disrupting chemicals (EDCs), widespread and easily ingested through the simple food chain, have been suggested to pose potential carcinogenic threats to human health. Considering food safety and public health, it is urgent to establish a sensitive and effective method to enrich and determine EDCs in food samples. Methods Novel hybrid nanocomposites Fe3O4@A‐TpBD@NH2‐MIL‐125(Ti) were synthesized through the formation of amide bonds. The as‐prepared Fe3O4 were innovatively encapsulated with 4‐aminobenzoic acid functionalized COF(A‐TpBD) to generate bare carboxyl (‐COOH), which formed amide bonds with the NH2‐MIL‐125(Ti), generating well‐defined and hierarchical hybrid materials. The Fe3O4@A‐TpBD@NH2‐MIL‐125(Ti) materials were used as the adsorbents for magnetic solid‐phase extraction (MSPE) coupled with high‐performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) to enrich and determine EDCs (E1, E2, E3 and BPA) from milk samples. Results Fe3O4@A‐TpBD@NH2‐MIL‐125(Ti) exhibited improved adsorption efficiency and selectivity based on π‐π stacking interaction, hydrogen bonding, electrostatic interaction, and the interaction between the hydroxyl group in EDCs and titanium ions (IV, [Ti]4+). Under the optimized conditions, Fe3O4@A‐TpBD@NH2‐MIL‐125(Ti)‐based MSPE coupled with HPLC/MS/MS showed good linearity with correlation coefficient (R2) ≥0.9983 and high sensitivity with limits of detection (LODs) in the range of 0.37–0.85 μg/L. Moreover, the developed method was successfully employed to detect EDCs in milk samples. Conclusions Fe3O4@A‐TpBD@NH2‐MIL‐125(Ti) possess good adsorption capability and selectivity for EDCs. In addition, the proposed MSPE‐HPLC/MS/MS method based on Fe3O4@A‐TpBD@NH2‐MIL‐125(Ti) is effective and sensitive for the determination of EDCs in real samples, which can be used as a robust alternative method to monitor EDCs in complex matrices.

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“…Recoveries and precisions were measured by the proposed method in meat samples with spiking standards at three concentrations (10, 100 and 200 μg kg −1 ). Recoveries ( R ) were determined on the basis of Eqn (4): 33,41

R (() %) = \frac{C_{spiked} - C_{matrix}}{C_{standard}} \times 100 %

in which C spiked , C matrix and C standard represent concentrations of spiked, unspiked meat samples and standard solution, respectively.…”

Section: Resultsmentioning

confidence: 99%

Highly sensitive determination of endocrine disrupting chemicals in foodstuffs through magnetic solid‐phase extraction followed by high‐performance liquid chromatography‐tandem mass spectrometry

Liu

et al. 2020

J Sci Food Agric

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BACKGROUND Endocrine disrupting chemicals (EDCs), proved to be potential carcinogenic threats to human health, have received great concerns in food field. It was essential to develop effective methods to detect EDCs in food samples. The present study proposed an efficient method to determine trace EDCs including estrone (E1), 17β‐estradiol (E2), estriol (E3) and bisphenol A (BPA) based on magnetic solid‐phase extraction (MSPE) coupled high‐performance liquid chromatography–tandem mass spectrometry (HPLC‐MS/MS) in meat samples. RESULTS Fe3O4@COF(TpBD)/TiO2 nanocomposites were synthesized via functionalization of magnetic covalent organic frameworks (COFs) with titanium dioxide (TiO2) nanoparticles, and used as absorbents of MSPE to enrich EDCs. The efficient EDCs enrichment relies on π–π stacking interaction, hydrogen bonding, and the interaction between titanium ions (IV, Ti4+) and hydroxyl groups in EDCs, which improves the selectivity and sensitivity. Under the optimized conditions, target EDCs were rapidly extracted through MSPE with 5 min. Combining Fe3O4@COF(TpBD)/TiO2 based MSPE and HPLC‐MS/MS to determine EDCs, good linearities were observed with correlation coefficient (R2) ≥ 0.9989. The limits of detection (LODs) and limits of quantification (LOQs) were 0.13–0.41 μg kg−1 and 0.66–1.49 μg kg−1, respectively. Moreover, the proposed method was successfully applied to real samples analysis. CONCLUSIONS The established MSPE‐HPLC‐MS/MS method was successfully applied to determine EDCs in meat samples with rapidness, improved selectivity and sensitivity. It shows great prospects for EDCs detection in other complicated matrices. © 2020 Society of Chemical Industry

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Simultaneous determination of non-steroidal anti-inflammatory drugs and natural estrogens in the mussels Mytilus edulis trossulus

Cited by 35 publications

References 56 publications

Evaluation of the Possibility of Using Hydroponic Cultivations for the Removal of Pharmaceuticals and Endocrine Disrupting Compounds in Municipal Sewage Treatment Plants

Evaluation of the Possibility of Using Hydroponic Cultivations for the Removal of Pharmaceuticals and Endocrine Disrupting Compounds in Municipal Sewage Treatment Plants

Synthesis of magnetic metal organic framework/covalent organic framework hybrid materials as adsorbents for magnetic solid‐phase extraction of four endocrine‐disrupting chemicals from milk samples

Highly sensitive determination of endocrine disrupting chemicals in foodstuffs through magnetic solid‐phase extraction followed by high‐performance liquid chromatography‐tandem mass spectrometry

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