2018
DOI: 10.1139/cjc-2017-0302
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Simultaneous determination of nifedipine and atenolol in combined dosage forms using a boron-doped diamond electrode with differential pulse voltammetry

Abstract: Combinations of nifedipine (NIF) and atenolol (ATN) are used for the treatment of arterial hypertension. Dosages values different from those presented on the label of pharmaceuticals can significantly impact a consumer’s health. To control the quality of the pharmaceuticals effectively, a method for the simultaneous determination of these both drugs using an anodically pretreated boron-doped diamond electrode coupled to differential pulse voltammetry technique was developed. The influence of supporting electro… Show more

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Cited by 20 publications
(4 citation statements)
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“…Different analytical methods have been applied for the determination of atenolol in biological fluids and pharmaceutical products such as HPLC [3, 11], LC-MS [5, 6], GC-MS [12], TLC [13], spectrophotometric and spectrofluorimetric methods [14–16], titrimetry [17], voltammetry [18], chemiluminescence [19], and capillary electrophoresis [20]. Several clean-up methods such as liquid-liquid extraction [3, 11, 12], solid phase extraction [21], and protein precipitation [22] have been used for extracting ATN from biological fluid samples.…”
Section: Introductionmentioning
confidence: 99%
“…Different analytical methods have been applied for the determination of atenolol in biological fluids and pharmaceutical products such as HPLC [3, 11], LC-MS [5, 6], GC-MS [12], TLC [13], spectrophotometric and spectrofluorimetric methods [14–16], titrimetry [17], voltammetry [18], chemiluminescence [19], and capillary electrophoresis [20]. Several clean-up methods such as liquid-liquid extraction [3, 11, 12], solid phase extraction [21], and protein precipitation [22] have been used for extracting ATN from biological fluid samples.…”
Section: Introductionmentioning
confidence: 99%
“…Для АДБЕ також характерні, зазвичай, слабка адсорбція для більшості органічних молекул, низький фоновий струм, низька ємність ПЕШ [21][22][23]. Усе це своєю чергою свідчить про високу чутливість електрода, тобто про інтенсивніший аналітичний сигнал.…”
Section: вступunclassified
“…With this in mind, an optimum boron doping concentration and sp 3 /sp 2 ratio can be selected for any particular electroanalytical sensing application, taking into consideration the specific sensitivity, potential window, and material stability requirements. For example, in small molecule sensing where high sensitivities are required, a boron concentration of ~8000 ppm is commonly used [ 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 ]. This mid- to high-doping concentration yields a material with high conductivity and moderate sp 2 impurities compared to heavily doped BDD [ 112 ].…”
Section: Opportunities For Optimizationmentioning
confidence: 99%