Simultaneous determination of newly developed antiviral agents in pharmaceutical formulations by HPLC-DAD

Alzoman, Nourah Z.; Maher, Hadir M.; Al-Subaie, Amal

doi:10.1186/s13065-016-0232-6

Cited by 116 publications

(59 citation statements)

References 20 publications

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“…In the field of medical chemistry, thiourea derivatives are of great interest due to their synthetic utility and biological importance. The thiourea moiety is a structural part of many bioactive compounds, that display antimicrobial [ 1 , 2 , 3 , 4 , 5 ], antifungal [ 6 ], antitubercular [ 2 , 7 , 8 ], antiviral [ 9 , 10 , 11 , 12 ], and central nervous system stimulating [ 13 , 14 , 15 , 16 ] properties. Derivatives of this group are also viewed as one of the most promising classes of anticancer agents.…”

Section: Introductionmentioning

confidence: 99%

“…A series of pyrimidine-thiourea conjugates were found to exhibit an inhibitory effect against histone lysine demethylase 1 (LSD1), overexpressed in gastric, prostate, lung, and breast cancer cells [ 25 , 26 ]. Moreover, miscellaneous thiourea derivatives carrying sulfonamide moieties were proven to possess antiproliferative properties by docking to the active site of the mitogen kinase enzyme (MK-2), controlling the signal transduction pathway in cell proliferation [ 5 , 27 , 28 ]. The cytotoxicity of acridinylthioureas originates from their ability to intercalate with DNA and as a result inhibit telomerase or topoisomerase action [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…A noticeable cytotoxic potential of mentioned thiourea-derived compounds was observed against a wide range of solid tumors, such as breast [ 4 , 6 , 17 , 21 , 23 , 32 , 33 ], lung [ 4 , 20 , 22 , 23 , 27 , 29 , 31 , 34 ], liver [ 5 ], prostate [ 4 , 18 , 31 , 32 , 33 ], cervical [ 4 , 29 , 30 ], brain [ 20 , 24 , 29 ], gastric [ 25 ], or colon [ 27 , 29 , 35 ] carcinoma, as well as human leukemia [ 29 ]. Simultaneously some of them, when tested on normal human cells, were found to possess a low cytotoxicity profile [ 1 , 17 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Simultaneously some of them, when tested on normal human cells, were found to possess a low cytotoxicity profile [ 1 , 17 , 20 ]. The main structural element of anticancer active thioureas were the presence of “the butterfly-like” tricyclic ring of acridine [ 29 ] or other heterocycles, such as pyrimidine [ 5 , 6 , 21 ], quinoline [ 27 ], quinazoline [ 22 , 23 ], furane [ 32 ], benzimidazole [ 4 ], chrysene [ 33 ], benzodioxole [ 18 ], triazole [ 17 ] or thiazole [ 20 ]. On the other hand, the most promising functionalities of a terminal aromatic ring were mainly electron-withdrawing substituents, such as nitro [ 27 , 33 , 35 ], cyano [ 17 ], trifluoromethyl/methoxy [ 17 , 19 ], halogeno [ 5 , 20 , 22 , 23 ], but also electron-withdrawing—methoxy [ 18 , 21 , 25 ] and methyl [ 24 ] groups.…”

Section: Introductionmentioning

confidence: 99%

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Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies

et al. 2018

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4-Chloro-3-nitrophenylthioureas 1–30 were synthesized and tested for their antimicrobial and cytotoxic activities. Compounds exhibited high to moderate antistaphylococcal activity against both standard and clinical strains (MIC values 2–64 μg/mL). Among them derivatives with electron-donating alkyl substituents at the phenyl ring were the most promising. Moreover, compounds 1–6 and 8–19 were cytotoxic against MT-4 cells and various other cell lines derived from human hematological tumors (CC50 ≤ 10 μM). The influence of derivatives 11, 13 and 25 on viability, mortality and the growth rate of immortalized human keratinocytes (HaCaT) was observed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies

et al. 2018

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“…Plants produce a myriad of organic compounds referred to as secondary metabolites (natural products) which differ in their structure and biosynthetic origins. These metabolites undergo chemical modifications, such as conjugation [ 1 , 2 ], and isomerization (positional and geometrical) [ 3 – 6 ], which further contribute to the high complexity of the plant metabolome. For instance, secondary metabolites such as hydroxycinnamic acid (HCA) derivatives have the potential to form conjugates with organic acids such as isocitric acid [ 1 ], tartaric acid [ 2 , 7 – 9 ], and quinic acid [ 4 , 10 , 11 ], thus forming hydroxycinnamoyl-isocitric acid [ 1 ], hydroxycinnamoyl-tartaric acid [ 2 , 7 – 9 ], and hydroxycinnamoyl-quinic acid [ 4 , 10 , 11 ], respectively.…”

Section: Introductionmentioning

confidence: 99%

Synchronized Survey Scan Approach Allows for Efficient Discrimination of Isomeric and Isobaric Compounds during LC-MS/MS Analyses

Masike

Madala

2018

Journal of Analytical Methods in Chemistry

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Liquid chromatography-mass spectrometry- (LC-MS-) based multiple reaction monitoring (MRM) methods have been used to detect and quantify metabolites for years. These approaches rely on the monitoring of various fragmentation pathways of multiple precursors and the subsequent corresponding product ions. However, MRM methods are incapable of confidently discriminating between isomeric and isobaric molecules and, as such, the development of methods capable of overcoming this challenge has become imperative. Due to increasing scanning rates of recent MS instruments, it is now possible to operate MS instruments both in the static and dynamic modes. One such method is known as synchronized survey scan (SSS), which is capable of acquiring a product ion scan (PIS) during MRM analysis. The current study shows, for the first time, the use of SSS-based PIS approach as a feasible identification feature of MRM. To achieve the above, five positional isomers of dicaffeoylquinic acids (diCQAs) were studied with the aid of SSS-based PIS method. Here, the MRM transitions were automatically optimized using a 3,5-diCQA isomer by monitoring fragmentation transitions common to all five isomers. Using the mixture of these isomers, fragmentation spectra of the five isomers achieved with SSS-based PIS were used to identify each isomer based on previously published hierarchical fragmentation keys. The optimized method was also used to detect and distinguish between diCQA components found in Bidens pilosa and their isobaric counterparts found in Moringa oleifera plants. Thus, the method was shown to distinguish (by differences in fragmentation patterns) between diCQA and their isobars, caffeoylquinic acid (CQA) glycosides. In conclusion, SSS allowed the detection and discrimination of isomeric and isobaric compounds in a single chromatographic run by producing a PIS spectrum, triggered in the automatic MS/MS synchronized survey scan mode.

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Shapeable Material Technologies for 3D Self‐Assembly of Mesoscale Electronics

Karnaushenko

Kang

Schmidt

2019

Adv Materials Technologies

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simple transistors and logics to highly integrated microcontrollers and displays, the latter of which utilizes some of the most technologically advanced processes available in the industry. [3] The success of these technologies has been achieved through enhanced integration of various active functional blocks such as transistors, digital logics, and analog circuits, along with advances in miniaturization and simplification of the overall manufacturing process, eventually leading to large scale, parallel fabrication of silicon chip-based microelectronic components and systems. [4,5] However, many of the manufacturing steps in assembling these electronic components remain either semiparallel or sequential in nature, including processes as dicing, pick and place, packaging, and final assembly of the device. Each additional sequential step increases costs and should ideally be avoided, however substantial streamlining is not always feasible in complex manufacturing processes. [6] More critically, highly integrated silicon-based devices still require several external supporting components for their operation such as wiring, powering, sensing, and communications that cannot be easily integrated within the planar surface of a silicon die. Thus, sensors, actuators, capacitors, coils, antennas, and optics, each crucial for the complete system, are typically placed separately from the silicon chip onto a printed circuit board (PCB), or integrated within another package (Figure 1a). While the need for ever decreasing sizes has demanded tremendous investments and efforts in the manufacture of completed assemblies, the miniaturizing of 3D electronic components (Figure 1b) and systems has nevertheless reached the range of mesoscopic sizes (<1 mm) where the manufacture and assembly of components experience challenges with respect to yield, costs, and reliability. [7] As a result, these issues limit the fabrication potential and commercial viability of components and systems to scales around 1 mm, [8] and despite efforts to improve the planar construction of mesoscopic 3D devices, the results are seen as inefficient and experience difficulties in achieving high performances while maintaining reasonable complexity. Despite the great success in manufacturing active electronics, such concerns are strongly related to the fabrication of passive electronic components like inductors, capacitors, antennas, and resonators where material properties (e.g., mechanical, magnetic, and electrical) and geometry play a crucial role. [8,9] In order to downscale these devices further and improve integration with active electronics, novel fabrication strategies are required.Electronic devices and their components are continually evolving to offer improved performance, smaller sizes, lower weight, and reduced costs, often requiring the state-of-the-art manufacturing and materials to do so. An emerging class of materials and fabrication techniques inspired by self-assembling biological systems shows promise as an alternative to the more traditional m...

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Simultaneous determination of newly developed antiviral agents in pharmaceutical formulations by HPLC-DAD

Cited by 116 publications

References 20 publications

Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies

Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies

Synchronized Survey Scan Approach Allows for Efficient Discrimination of Isomeric and Isobaric Compounds during LC-MS/MS Analyses

Shapeable Material Technologies for 3D Self‐Assembly of Mesoscale Electronics

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