Simultaneous determination of Nebivolol hydrochloride and Valsartan in their binary mixture using different validated spectrophotometric methods

Meselhy, Esraa M.; Kheir, Afaf Aboul; Henawee, Magda M. El; Elmasry, Manal S.

doi:10.1016/j.saa.2020.118083

Cited by 14 publications

(6 citation statements)

References 11 publications

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“…The advanced concentration value method is a new approach derived from concentration value method which eliminate the use of regression equation and lets the recording of the concentration of the studied drug directly throw the spectrum with good accuracy and precision. The developed methods simple, accurate and also have the advantage of didn't require preceding treatment, complicated steps or use of organic harmful solvents like that usually used in the reported methods HPLC [9][10][11][12][13][14][15][16][17], LC-MS/MS [18], and spectrophotometry [19][20][21]. Although the use of ACV was easier and lower the manipulation steps, but in CC, obtaining the zero-order absorption spectrum ensures the drug profile and working at λmax ensured maximum accuracy and precision.…”

Section: Discussionmentioning

confidence: 99%

“…During the literature survey, many methods were found for the analysis of both NEB and VAL in its combined dosage form. Those methods include HPLC [9][10][11][12][13][14][15][16][17], LC-MS/MS [18], and spectrophotometry [19][20][21]. The aim of the study is to apply different approaches to determine the drug studied in its zeroorder absorption spectrum without interference from one another.…”

Section: Introductionmentioning

confidence: 99%

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Application of two different spectrophotometric approaches for the determination of a new antihypertensive combination: Graphical and statistical representation of the data

et al. 2022

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Speciﬁc, and precise spectrophotometric methods are developed and validated for the simultaneous determination of the binary antihypertensive mixture nebivolol hydrochloride and valsartan in the zero-order spectrum. The methods applied for the determination of this antihypertensive mixture are constant center spectrophotometric resolution technique, constant center spectrum subtraction resolution technique, and advanced concentration value. Nebivolol hydrochloride was determined by its zero order spectra at 280 and 213 nm while for valsartan it determined by its zero order spectra at 250 nm. All developed methods were applied for the determination of the cited drugs in the pharmaceutical formulation and the results obtained were statistically compared with each other and with those of the reported method. The comparison showed that there is no significant difference between the proposed methods and the reported method regarding both accuracy and precision.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of two different spectrophotometric approaches for the determination of a new antihypertensive combination: Graphical and statistical representation of the data

et al. 2022

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“…Satisfactory % recoveries and low values of % RSD assured the good accuracy of the proposed methods, as shown in Table 2. To prove the accuracy of the proposed methods, the results of the assay of the studied drugs were compared with those obtained using reported methods 9,23 . Data in Table 2 and Table 3 illustrate the accuracy and precision of the two methods, and they have no remarkable differences, as assured by statistical analysis of the data using the variance ratio F-test and the Student t-test.…”

Section: Methods Validationmentioning

confidence: 99%

“…range of analytical techniques, viz UV spectrophotometry 9,10 , spectrofluorimetry 11,12 , HPLC [13][14][15] , HPTLC 16 , and electrochemistry 17 .…”

mentioning

confidence: 99%

Green fluorometric strategy for simultaneous determination of the antihypertensive drug telmisartan (A tentative therapeutic for COVID-19) with Nebivolol in human plasma

Salim

Radwan

Hadad

et al. 2023

Sci Rep

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Telmisartan (TEL) and Nebivolol (NEB) are frequently co-formulated in a single dosage form that is frequently prescribed for the treatment of hypertension, moreover, telmisartan is currently proposed to be used to treat COVID19-induced lung inflammation. Green rapid, simple, and sensitive synchronous spectrofluorimetric techniques for simultaneous estimation of TEL and NEB in their co-formulated pharmaceutical preparations and human plasma were developed and validated. Synchronous fluorescence intensity at 335 nm was used for TEL determination (Method I). For the mixture, the first derivative synchronous peak amplitudes (D1) at 296.3 and 320.5 nm were used for simultaneous estimation of NEB and TEL, respectively (Method II). The calibration plots were rectilinear over the concentration ranges of 30–550 ng/mL, and 50–800 ng/mL for NEB and TEL, respectively. The high sensitivity of the developed methods allowed for their analysis in human plasma samples. NEB`s Quantum yield was estimated by applying the single-point method. The greenness of the proposed approaches was evaluated using the Eco-scale, National Environmental Method Index (NEMI), and Green Analytical Procedure Index (GAPI) methods.

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“…In a review of associated scientific articles, numerous previous analytical methods have been developed and used for the quantitation of valsartan in samples containing biological fluids and pharmaceutical products. Published methods involve the separation and determination of valsartan by various analytical approaches either with or without other drugs such as high-performance liquid chromatography (HPLC) through different detectors such as UV detectors (Kumar, et al, 2015;Pebdani, et al, 2016;Babarahimi, et al, 2018;Shaikh, et al, 2020;Marghany, et al, 2020), fluorescence detection (Macek, Klima and Ptacek, 2006;del Rosario Brunetto, et al, 2009), as well as diode-array detection (Farajzadeh, Khorram and Pazhohan, 2016); a modern class of separation system based on "ultra-high-performance liquid chromatography" (UPLC) (Krishnaiah, et al, 2010;Vojta, et al, 2015;Moussa, et al, 2018); liquid chromatography-tandem mass spectrometry (LC-MS/MS) (Selvan, et al, 2007, Koseki, et al, 2007, Annadi, El Sheikh and Mohamed, 2019; electroanalytical voltammetry methods (Eisele, et al, 2014;Mansano, et al, 2015); and UV-vis spectrophotometry (Satana, et al, 2001;Erk, 2002;Lotfy, et al, 2015;Eissa and Abou Al Alamein 2018;Meselhy, et al, 2020;Kamal, Marie and Hammad 2020). As well the fluorescence determination of valsartan, several procedures have been described in previous articles for its determination were including native fluorescence, a first derivative fluorescence and the synchronous fluorescence (Cagigal, et al, 2001;Shaalan and Belal, 2010;El-Shaboury, et al, 2012;El-Kosasy, et al, 2015;Dinc, Ertekin and Buker, 2017;Ragab, et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

New Fluorescence Quenching Approach for Determination of Valsartan in Certain Tablets and Spiked Biological Fluids

Ali

2020

ARO

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A new, simple, selective, sensitive, fast, economical, and reliable fluorescence quenching method for the quantitation of valsartan was investigated using basic fuchsin act as a fluorometric dye. The method was depended on the detection quenching influence of valsartan on the fluorescence intensity of basic fuchsin and the reaction between valsartan and basic fuchsin in a McIlvaine buffer medium at pH = 6 to yield a new basic fuchsin–valsartan non-fluorescent complex. The excitation and emission of basic fuchsin fluorescence signal were identified at 535 and 728 nm, respectively. A fluorescence quenching value (ΔF) displayed a very good linear relationship (R2 = 0.9992) with valsartan concentration ranging from 0.003 to 3 μg/mL, a detection limit as low as 0.0009 μg/mL with a high precision and accuracy (RSD% <3). Significantly, no interference effect was found due to the presence of other ingredients commonly found in medical formulations. The acquired data were statistically compared with those acquired from reported chromatographic method and were observed to be in excellent agreement at a 95% confidence level; the planned fluorescence quenching procedure was subsequently utilized to detected the concentration of valsartan in spiked biological fluids and commercial medical tablets.

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Simultaneous determination of Nebivolol hydrochloride and Valsartan in their binary mixture using different validated spectrophotometric methods

Cited by 14 publications

References 11 publications

Application of two different spectrophotometric approaches for the determination of a new antihypertensive combination: Graphical and statistical representation of the data

Application of two different spectrophotometric approaches for the determination of a new antihypertensive combination: Graphical and statistical representation of the data

Green fluorometric strategy for simultaneous determination of the antihypertensive drug telmisartan (A tentative therapeutic for COVID-19) with Nebivolol in human plasma

New Fluorescence Quenching Approach for Determination of Valsartan in Certain Tablets and Spiked Biological Fluids

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