Simultaneous determination of naproxen, ibuprofen and diclofenac in wastewater using solid-phase extraction with high performance liquid chromatography

Madikizela, Lawrence Mzukisi; Chimuka, Luke

doi:10.4314/wsa.v43i2.10

Cited by 82 publications

(64 citation statements)

References 22 publications

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“…Concentrations of DIC were measured in water and soft tissues by using a high performance liquid chromatography-ultraviolet (HPLC-UV) detection method. Water samples were analyzed by using the method of Madikizela et al (2017) (Madikizela and Chimuka, 2017) with slightly modifications. Water samples (100 mL) were extracted by solid phase extraction (Oasis MAX 6cc 150 mg solid-phase extraction cartridges, Waters).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The influence of temperature on the effects induced by Triclosan and Diclofenac in mussels

Freitas

Coppola

Costa

et al. 2019

Science of The Total Environment

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Little is known about the consequences of exposure to pharmaceuticals and personal care products (PPCPs) in elevated temperatures associated with climate change. To increase the knowledge on this topic, Mytilus galloprovincialis mussels were exposed to 1.0 µg/L of either the antimicrobial Triclosan (TCS) or the pharmaceutical drug Diclofenac (DIC), at control (17ºC) and 4ºC raised (21ºC) temperatures for 28 days.Triclosan and DIC concentrations in the water and tissues were subsequently measured and related to biomarker responses including: energy metabolism (electron transport system (ETS) activity, glycogen and protein reserves), oxidative stress markers, glutathione balance between the reduced and the oxidised form (GSH/GSSG), and damage to proteins and lipids. Mussels responded to the increase in temperature and drug exposure by lowering their metabolic rate (decreased ETS), increasing their endogenous reserves and antioxidant defences, thus preventing oxidative stress damage, with the exception of DIC exposure at the higher temperature.In all cases, GSH/GSSG ratio was reduced in detriment of the antioxidant form at both PPCPs exposures and elevated temperature with no additive effect due to combined stressors. Overall, either drug exposure or increased temperature could compromise the ability of mussels to withstand further insults.

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Section: Accepted Manuscriptmentioning

confidence: 99%

The influence of temperature on the effects induced by Triclosan and Diclofenac in mussels

Freitas

Coppola

Costa

et al. 2019

Science of The Total Environment

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“…It was below the limit of detection in all the upstream samples (BU, FU, SU and TU), but present in the midstream and downstream samples of Bloukrans and Swartkops Rivers, and downstream sample of Tyhume River. This compound has been reported in wastewaters and treated effluents around the world (Thomaidi et al 2017;Madikizela et al 2014;Wang et al 2014).…”

Section: Resultsmentioning

confidence: 92%

Occurrence of selected endocrine disrupting compounds in the eastern cape province of South Africa

Farounbi

Ngqwala

2020

Environ Sci Pollut Res

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Endocrine-disrupting compounds are attracting attention worldwide because of their effects on living things in the environment. Ten endocrine disrupting compounds: 4-nonylphenol, 2,4-dichlorophenol, estrone, 17β-estradiol, bisphenol A, 4-tertoctylphenol, triclosan, atrazine, imidazole and 1,2,4-triazole were investigated in four rivers and wastewater treatment plants in this study. Rivers were sampled at upstream, midstream and downstream reaches, while the influent and effluent samples of wastewater were collected from treatment plants near the receiving rivers. Sample waters were freeze-dried followed by extraction of the organic content and purification by solid-phase extraction. Concentrations of the compounds in the samples were determined with ultra-high performance liquid chromatography-tandem mass spectrometry. The instrument was operated in the positive electrospray ionization (ESI) mode. The results showed that these compounds are present in the samples with nonylphenol > dichlorophenol > bisphenol A > triclosan > octylphenol > imidazole > atrazine > triazole > estrone > estradiol. Nonylphenol has its highest concentration of 6.72 μg/L in King Williams Town wastewater influent and 2.55 μg/L in midstream Bloukrans River. Dichlorophenol has its highest concentration in Alice wastewater influent with 2.20 μg/L, while it was 0.737 μg/L in midstream Bloukrans River. Uitenhage wastewater effluent has bisphenol A concentration of 1.684 μg/L while it was 0.477 μg/L in the downstream samples of the Bloukrans River. Generally, the upstream samples of the rivers had lesser concentrations of the compounds. The wastewater treatment plants were not able to achieve total removal of the compounds in the wastewater while runoffs and wastes dump from the cities contributed to the concentrations of the compounds in the rivers.

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“…The values for diclofenac in 24 hours 78%, within 48 hours of 81% in 72 hours and 82%, respectively, indicating the release of less diclofenac than ibuprofen per unit of time. This can be due to lower solubility in water [19] , highly lipophilicity [20] of diclofenac as well as small size and more sterile effect of diclofenac compared to ibuprofen [21] that is not able to release easily between layers. Comparing to the old and industrial methods, drug loading between LDH layers lead to the different release rate of drug and enhance the solubility of the drug and also, reduce a side effect of it.…”

Section: Uv-vis Spectrum Of Ibuprofen and Diclofenac Release Assaymentioning

confidence: 99%

Synthesis and Application of Magnetic@Layered Double Hydroxide Multicore-Shell Nanostructure as a Novel Anti-Inflammatory Drugs Nanocarrier

Yousefi¹,

Tarhriz²,

Eyvazi³

et al. 2020

Preprint

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Background: magnetic nanocomposites with a core-shell nanostructure has huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experimentand is used as novel drug nanocarrier.Methods: Magnetic nanospheres were synthesized by a facile one-step solvothermal route, and in following, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as the anti-inflammatory drugs by using exchange anion experiment, the basal spacing of synthesized layered double hydroxides were compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively. Results: The results indicated Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs by bridging bidentate interaction. Besides, in vitro drug release experiments in pH 7.4, Phosphate-buffered saline (abbreviated PBS) showed the constant release profiles with Ibuprofen and diclofenac as model drugs with different lipophilicity and water solubility and size and steric effect. Conclusions: The Fe3O4@LDH-ibuprofen and Fe3O4@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity and high thermal stability. We confirm, which Fe3O4@LDH multicore-shell nanostructure will have potential application for constant drug delivery.

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Simultaneous determination of naproxen, ibuprofen and diclofenac in wastewater using solid-phase extraction with high performance liquid chromatography

Cited by 82 publications

References 22 publications

The influence of temperature on the effects induced by Triclosan and Diclofenac in mussels

The influence of temperature on the effects induced by Triclosan and Diclofenac in mussels

Occurrence of selected endocrine disrupting compounds in the eastern cape province of South Africa

Synthesis and Application of Magnetic@Layered Double Hydroxide Multicore-Shell Nanostructure as a Novel Anti-Inflammatory Drugs Nanocarrier

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