Simultaneous determination of major type A and B trichothecenes, zearalenone and certain modified metabolites in Finnish cereal grains with a novel liquid chromatography-tandem mass spectrometric method

Nathanail, Alexis V.; Syvähuoko, Jenna; Malachová, Alexandra; Jestoi, Marika; Varga, Elisabeth; Michlmayr, Herbert; Adam, Gerhard; Sieviläinen, Elina; Berthiller, Franz; Peltonen, Kimmo

doi:10.1007/s00216-015-8676-4

Cited by 144 publications

(103 citation statements)

References 37 publications

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“…Elevated HT2 + T2 concentrations in oat grains have been reported in Norway (Hofgaard et al 2016a), Sweden (Fredlund et al 2013), Finland (Nathanail et al 2015), Switzerland (Schirdewahn et al 2016) and in the UK (Edwards 2009). The goal of this study was to identify possible associations between weather conditions at specific growth stages of oats and the content of HT2 + T2 in harvested oat grains.…”

Section: Discussionmentioning

confidence: 97%

HT-2 and T-2 toxins in Norwegian oat grains related to weather conditions at different growth stages

et al. 2018

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High concentrations of the mycotoxins HT-2 and T-2 (HT2 + T2), primarily produced by Fusarium langsethiae, have occasionally been detected in Norwegian oat grains. In this study, we identified weather variables influencing accumulation of HT2 + T2 in Norwegian oat grains. Oat grain samples from farmers' fields were collected together with weather data (2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013). Spearman rank correlation coefficients were calculated between the HT2 + T2 contamination in oats at harvest and a range of weather summarisations within estimated phenological windows of growth stages in oats (tillering, flowering etc.). Furthermore, we developed a mathematical model to predict the risk of HT2 + T2 in oat grains. Our data show that adequate predictions of the risk of HT2 + T2 in oat grains at harvest can be achieved, based upon weather data observed during the growing season. Humid and cool conditions, in addition to moderate temperatures during booting, were associated with increased HT2 + T2 accumulation in harvested oat grains, whereas warm and humid weather during stem elongation and inflorescence emergence, or cool weather and absence of rain during booting reduced the risk of HT2 + T2 accumulation. Warm and humid weather immediately after flowering increased the risk, while moderate to warm temperatures and absence of rain during dough development, reduced the risk of HT2 + T2 accumulation in oat grains. Our data indicated that HT2 + T2 contamination in oats is influenced by weather conditions both pre-and post-flowering. These findings are in contrast with a previous study examining the risk of deoxynivalenol contamination in oat reporting that toxin accumulation was mostly influenced by weather conditions from flowering onwards.

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Section: Discussionmentioning

confidence: 97%

HT-2 and T-2 toxins in Norwegian oat grains related to weather conditions at different growth stages

et al. 2018

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“…Oat is a commonly grown crop in temperate regions, and high DON concentrations in oats have been reported in Norway (Hofgaard et al 2016a), Sweden (Fredlund et al 2013) and Finland (Nathanail et al 2015). In addition, DON is also detected in oats from Switzerland (Schirdewahn et al 2016), Canada (Tamburic-Ilincic 2010) and the U.K. (Edwards 2009).…”

Section: Summarizing Comments On the Relationship Between Weather Conmentioning

confidence: 99%

DON content in oat grains in Norway related to weather conditions at different growth stages

et al. 2016

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High concentrations of the mycotoxin deoxynivalenol (DON), produced by Fusarium graminearum have occurred frequently in Norwegian oats recently. Early prediction of DON levels is important for farmers, authorities and the Cereal Industry. In this study, the main weather factors influencing mycotoxin accumulation were identified and two models to predict the risk of DON in oat grains in Norway were developed: (1) as a warning system for farmers to decide if and when to treat with fungicide, and (2) for authorities and industry to use at harvest to identify potential food safety problems. Oat grain samples from farmers' fields were collected together with weather data (2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013).A mathematical model was developed and used to estimate phenology windows of growth stages in oats (tillering, flowering etc.). Weather summarisations were then calculated within these windows, and the Spearman rank correlation factor calculated between DONcontamination in oats at harvest and the weather summarisations for each phenological window. DON contamination was most clearly associated with the weather conditions around flowering and close to harvest. Warm, rainy and humid weather during and around flowering increased the risk of DON accumulation in oats, as did dry periods during germination/seedling growth and tillering. Prior to harvest, warm and humid weather conditions followed by cool and dry conditions were associated with a decreased risk of DON accumulation. A prediction model, including only pre-flowering weather conditions, adequately forecasted risk of DON contamination in oat, and can aid in decisions about fungicide treatments.

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“…The importance of proper sample preparation and the introduction of laboratory robotics for high-throughput analyses have also found necessary recognition (1,9,18,20,(36)(37)(38)(39)(40). These developments will improve fast detection of foodborne pathogens and their toxins, allergens and other harmful components in food, and also help producers, food control authorities and consumers to detect adulterations and protect safe and original food (39)(40)(41). Ensuring food safety and identifi cation, monitoring and FINAL PRODUCT assessing of both food authenticity and foodborne hazards will require further development of already existing mass spectrometry (MS)-based methods (34,(38)(39)(40)(41)(42).…”

Section: Foodomics and The Application Of 'Omic' Methods In Food Analmentioning

confidence: 99%

“…These developments will improve fast detection of foodborne pathogens and their toxins, allergens and other harmful components in food, and also help producers, food control authorities and consumers to detect adulterations and protect safe and original food (39)(40)(41). Ensuring food safety and identifi cation, monitoring and FINAL PRODUCT assessing of both food authenticity and foodborne hazards will require further development of already existing mass spectrometry (MS)-based methods (34,(38)(39)(40)(41)(42). In proteomics and peptidomics, MS represents a very powerful, high-performance method and is an excellent tool for protein and peptide identifi cation and quantitative analysis.…”

Section: Foodomics and The Application Of 'Omic' Methods In Food Analmentioning

confidence: 99%

“…It is a direct injection of diluted (or extracted) sample into the system for liquid chromatography (LC) without a complex cleanup procedure. This approach, when followed by LC-MS/MS or less frequently capillary electrophoresis (CE)-MS/MS, provides a robust method for detection and quantifi cation (41)(42)(43). Conventional sample preparation methods in food analysis that are used especially for the detection of small molecules are liquid--liquid extraction, solid-liquid extraction and supercritical fl uid extraction (1).…”

Section: Sample Preparationmentioning

confidence: 99%

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Foodomics and Food Safety: Where We Are

Andjelković

Gajdošik

Gašo-Sokač

et al. 2017

Food Technol. Biotechnol.

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SummaryThe power of foodomics as a discipline that is now broadly used for quality assurance of food products and adulteration identifi cation, as well as for determining the safety of food, is presented. Concerning sample preparation and application, maintenance of highly sophisticated instruments for both high-performance and high-throughput techniques, and analysis and data interpretation, special att ention has to be paid to the development of skilled analysts. The obtained data shall be integrated under a strong bioinformatics environment. Modern mass spectrometry is an extremely powerful analytical tool since it can provide direct qualitative and quantitative information about a molecule of interest from only a minute amount of sample. Quality of this information is infl uenced by the sample preparation procedure, the type of mass spectrometer used and the analyst's skills. Technical advances are bringing new instruments of increased sensitivity, resolution and speed to the market. Other methods presented here give additional information and can be used as complementary tools to mass spectrometry or for validation of obtained results. Genomics and transcriptomics, as well as affi nity-based methods, still have a broad use in food analysis. Serious drawbacks of some of them, especially the affi nity-based methods, are the cross-reactivity between similar molecules and the infl uence of complex food matrices. However, these techniques can be used for pre-screening in order to reduce the large number of samples. Great progress has been made in the application of bioinformatics in foodomics. These developments enabled processing of large amounts of generated data for both identifi cation and quantifi cation, and for corresponding modeling.

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Simultaneous determination of major type A and B trichothecenes, zearalenone and certain modified metabolites in Finnish cereal grains with a novel liquid chromatography-tandem mass spectrometric method

Cited by 144 publications

References 37 publications

HT-2 and T-2 toxins in Norwegian oat grains related to weather conditions at different growth stages

HT-2 and T-2 toxins in Norwegian oat grains related to weather conditions at different growth stages

DON content in oat grains in Norway related to weather conditions at different growth stages

Foodomics and Food Safety: Where We Are

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