Simultaneous determination of ingredients in a cold medicine by cyclodextrin-modified microemulsion electrokinetic chromatography

New applications of cyclodextrins in electrically driven chromatographic systems: a review

“…The background electrolyte was 0.81% (w/w) pentan, 6.61% (w/w) 1-butanol, 2% (w/w) 2-propanol, 4.47% (w/w) sodium dodecyl sulfate, 86.11% (w/w) 10 mM sodium tetraborate and 3 mM 2,6-di-O-methyl-β-CD. It was concluded that the method can be applied for the separation of these analytes, the results being similar to those obtained by HPLC (Okamoto et al, 2004). Cefadroxil enantiomers were separated by capillary electrochromatography the optimal background electrolyte consisted of 28.5 mM sodium acetate, 0.95% (v/v) acetic acid, 19 mM β-CD and 5% (v/v) 2-propanol in formamide solution (pH 7.0).…”

Recent advances in the development and application of microemulsion EKC

“…Fig. 5 shows the separation of ingredients in a cold medicine using a similar MEEKC method [88]. A sample stacking technique was used to analyse amoxicillin (a penicillin compound) in a commercial formulation by MEEKC [68], which showed up to a 40-fold increase in sensitivity and achieved LOD's of between 10 and 25 mg/ L. Furlanetto [27] …”

Development and Validation of a New HPLC Method for the Simultaneous Determination of Paracetamol, Ascorbic Acid, and Pseudoephedrine HCl in their Co-formulated Tablets. Application to in vitro Dissolution Testing

“…For PE, the USP 3 used different HPLC methods for its pure form and different formulations either alone or with combined drugs, while the BP 4 used a titrimetric assay for PE pure form and HPLC method for its tablets and oral drops. As well, many methods were reported for the determination of binary mixtures containing two of the studied drugs either alone or with other drugs, such as spectrophotometry, 5,6 HPLC, [7][8][9] electrokinetic chromatography, 10 and differential pulse voltammetry.…”