Simultaneous determination of Indigotin and Ponceau-4R in food samples by using Vierordt's method, ratio spectra first order derivative and derivative UV spectrophotometry

Determination of Carmoisine, Allura red and Ponceau 4R in sweets and soft drinks by Differential Pulse Polarography

“…In order to solve these difficulties, mathematical treatments of the spectra have been proposed (Saguy et al, 1978;Hofer and Jenewein, 1997;Capitan-Vallvey et al, 1998;Berzas Nevado et al, 1999a, b). Several recent papers demonstrate the interest of the UV-visible spectrometry (Kiroglu and Ozdemir, 2000;Capitan Vallvey, 2002;Altinoz and Toptan, 2003;Koyuncu et al, 2003).…”

Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form

“…PAR showed linear correlation between amplitude values and their corresponding concentrations in the range of 1.5-20 μg/mL (Table 3). Another method for resolving interferences between PAR and DAS spectra is the 1 DD method [19][20][21]. The zero order absorption spectrum of PAR is recorded, divided by the absorption spectrum of a standard solution of known concentration of DAS (2 μg/mL) and then the 1 D spectrum is obtained.…”

“…Thus, the aim of this work was to develop and validate spectrophotometric methods for the determination of PAR and DAS in combination without sample pretreatment. Among various techniques, spectrophotometric methods remain the simplest, fastest and less expensive for the determination of drug mixtures [19][20][21]. Direct UV-absorbance measurement (zero order) is subject to interference from degradation products and/or excipients.…”

“…Two methods were developed and validated: first derivative ( 1 D) and first derivative ratio ( 1 DD) spectrophotometric methods to enhance the resolution of overlapping bands. The derivative spectrophotometry can be used for simultaneous determination of many drugs, it is applied by selecting a wavelength where the compound to be determined has a reasonable value while the contribution of the other compound is almost zero [19][20][21].…”

Simultaneous Determination of Carmoisine and Ponceau 4R

“…To avoid time-consuming clean-up procedures, attempts to resolve complex spectra by using instrumental approaches or various chemometric methods have been made. Derivative techniques (Altionz and Toptan 2002;Altinoz and Toptan 2003;Kiroglu and Ozdemir 2000) and multivariate statistical analysis (Koyuncu et al 2003;Oveisi et al 2003;Dinc et al 2002;Lopez-de-Alba et al 2002;Pravdova et al 2002;Berzas Nevado et al 1999) have been successfully applied to the multi-component analysis of mixtures by UV/Vis molecular absorption spectrophotometry. All these approaches are useful for the reduction of band-overlapping errors in quantitative analysis, but they are often used for more complex mixtures.…”