Simultaneous Determination of Hydrazine, Methylhydrazine and 1,1-Dimethylhydrazine in Waters by HPLC with Spectrophotometric Detection Using Catalysis to Obtain Derivatives

Practical Manufacturing Process for Baloxavir Marboxil: Efficient Route to a Tricyclic Triazinanone Scaffold

“…Investigating the reaction conditions, more than 1.3 equiv of hydrazine as a reactant efficiently completed the reaction in 3 h. , Notably, the residual amount of hydrazine in the final extract was not much affected regardless of the number of equivalents charged in the reaction . Gratifyingly, appropriate wash of a dichloromethane solution of the extracts with water showed that hydrazine was purged into the aqueous layer, and the residual level was confirmed to be below the safety criterion before concentration of the extract in the scaled-up manufacturing. Incidentally, regardless of our efforts to avoid the usage of hydrazine, trials with ethanolamine or ethylenediamine to replace it led to inferior outcomes regarding the quality impact on 24 in the next step.…”

A novel Salen-based dual channel sensor for easy and selective nanomolar detection of l-cysteine

“…21 Also, sensitivity is another major issue with HPLC. 25 Whereas the electrochemical method possesses high sensitivity and is facile, its selectivity is poor and it exhibits excellent activity only upon proper modification. 26 In order to circumvent this problem, a variety of sensors have been reported, employing intriguing detection techniques to monitor L-cysteine.…”

“…21 Also, sensitivity is another major issue with HPLC. 25 Whereas the electrochemical method possesses high sensitivity and is facile, its selectivity is poor and it exhibits excellent activity only upon proper modification. 26…”

Electrochemically Modified Poly(dicyandiamide) Electrodes for Detecting Hydrazine in Neutral pH

“…There have been multiple detection methods reported for hydrazine determination, such as fluorimetry, spectrophotometry, chromatography techniques, , chemiluminescence, surface-enhanced Raman spectroscopy, and electrochemical sensors. , Although the electrochemical sensor method offers one of the simplest and cost-effective approaches with on-field sensing capability, hydrazine oxidation at the bare electrode is poorly catalyzed and requires a high overpotential . Thus, several metal/metal oxide, − metal complex, and organic mediator ,, -modified electrodes were developed.…”