Simultaneous determination of glucuronides of trimetozine in human urine by gas chromatography

Kawahara, Kenji; Ofuji, Tatsuya

doi:10.1016/s0378-4347(00)81858-7

Cited by 5 publications

(1 citation statement)

References 2 publications

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“…The Trimetozine synthesis is a popular example of this reaction as illustrated in Graph 1. 19 Graph 1. Synthesis of Trimetozine in Me-THF in presence of sodium carbonate.…”

Section: Introductionmentioning

confidence: 99%

Steady-State Simulation of the Counter Current Liquid-Liquid Ex-Traction: Trimetozine Synthesis as a Case Study

Hosni

Houson²,

Benyahia³

et al. 2019

Preprint

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The countercurrent liquid-liquid extraction is a crucial step in industrial process to purify and extract a compound of inter-ests for its impurities. This step requires generally challenging and time-consuming optimisation of numerous factors that affect the overall yield of extraction and the energy needed. The simulation of this process has been investigated in this pa-per using a Non-Random Two Liquid model implemented as a thermodynamic method in Aspen. The outcome of this model enables the evaluation of the partition coefficients of the different analytes of a mixtures at the different compart-ments of extraction platform. In addition, this steady-state model allows a more straightforward optimisation of the factors that drive the performance of extraction.

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“…The Trimetozine synthesis is a popular example of this reaction as illustrated in Graph 1. 19 Graph 1. Synthesis of Trimetozine in Me-THF in presence of sodium carbonate.…”

Section: Introductionmentioning

confidence: 99%

Steady-State Simulation of the Counter Current Liquid-Liquid Ex-Traction: Trimetozine Synthesis as a Case Study

Hosni

Houson²,

Benyahia³

et al. 2019

Preprint

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Pre-Column (HPLC) Fluorescence Labelling of Glucuronides

Lingeman¹,

Meussen²,

Zouwen³

et al. 1986

BIOACTIVE ANALYTES, Including CNS Drugs, Peptides, and Enantiomers

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Derivatization reactions in the gas—liquid chromatographic analysis of drugs in biological fluids

Hulshoff¹,

Lingeman²

1984

Journal of Pharmaceutical and Biomedical Analysis

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Alkylation, acylation, silylation and other derivatization reactions applied to the gas chromatographic analysis of drugs in biological matrices are reviewed. Reaction conditions are discussed in relation to reaction mechanisms. Detector-oriented labelling of drugs, and derivatization with chiral reagents for the separation of enantiomers are surveyed. Data on the sample clean-up, derivatization and GLC analysis of more than 300 drugs and related compounds are listed.

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Simultaneous determination of glucuronides of trimetozine in human urine by gas chromatography

Cited by 5 publications

References 2 publications

Steady-State Simulation of the Counter Current Liquid-Liquid Ex-Traction: Trimetozine Synthesis as a Case Study

Steady-State Simulation of the Counter Current Liquid-Liquid Ex-Traction: Trimetozine Synthesis as a Case Study

Pre-Column (HPLC) Fluorescence Labelling of Glucuronides

Derivatization reactions in the gas—liquid chromatographic analysis of drugs in biological fluids

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