Simultaneous determination of gatifloxacin and ambroxol hydrochloride from tablet dosage form using reversed-phase high performance liquid chromatography

Shahed, Mirza; Nanda, Rabindra K.; Dehghan, Muhammad Hassan; Nasreen, Huda; Feroz, Shaikh

doi:10.1016/s1872-2059(08)60021-8

Cited by 7 publications

(4 citation statements)

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“…In GATI analysis were applied HPLC and CE. The HPLC techniques involved FLD [ 20 , 27 , 29 , 79 , 95 ], UV detection [ 20 , 24 , 25 , 54 , 96 – 99 ], and MS detection [ 96 ]. The detection in CE involved UV detection [ 39 , 52 , 56 ], capacitively coupled contactless conductivity detection [ 83 ] and electroluminescence [ 73 ].…”

Section: Fourth Generation Fluoroquinolonesmentioning

confidence: 99%

“…Ion pair reagents were TBAA [ 20 ], TEA [ 25 , 27 , 95 ], TBAmBr [ 29 ], TBA·Cl [ 79 ]. The other constituents were phosphates [ 24 , 29 , 54 , 97 – 99 ], SDS [ 20 ], citric acid [ 20 , 96 ], 0.1% FA [ 27 , 96 ], TFA [ 79 ], ammonium acetate [ 96 ], phosphoric acid [ 95 ]. The pH of the mobile phase was acidic.…”

Section: Fourth Generation Fluoroquinolonesmentioning

confidence: 99%

“…The pH of the mobile phase was acidic. The elution was both iscocratic [ 20 , 24 , 29 , 54 , 79 , 95 , 97 – 99 ] and gradient [ 27 , 96 ]. HPLC analysis was performed at ambient temperature with the exception of [ 54 , 96 ] and [ 95 ], where it was performed at 35 and 28 °C, respectively.…”

Section: Fourth Generation Fluoroquinolonesmentioning

confidence: 99%

“…The sample preconditioning involved pulverization and dissolution [ 25 , 39 , 99 ], ultrafiltration [ 20 , 97 ], online extraction on column [ 29 ], protein precipitation with ACN [ 27 ] or methanol or a mixture of ACN and methanol [ 24 ], dilution with a proper solvent [ 52 , 56 , 79 ], LLE [ 54 , 83 , 98 ], SPE [ 73 , 79 , 95 ], and ASE (accelerated solvent extraction) [ 96 ]. Fu et al [ 73 ] reported that SPE lead to successful clean-up of the sample and that no unacceptable interference was observed during the analysis.…”

Section: Fourth Generation Fluoroquinolonesmentioning

confidence: 99%

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Analytical Methods for Determining Third and Fourth Generation Fluoroquinolones: A Review

Czyrski

2016

Chromatographia

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Fluoroquinolones of the third and fourth generation posses wide bactericidal activity. Monitoring concentrations of antibacterial agents provides effective therapy and prevents the increase of bacterial resistance to antibiotics. The pharmacodynamic parameters that best describe fluoroquinalone activity are AUC/MIC and C max/MIC. Determining the level of this type of drug is essential to reach the effective concentration that inhibits the growth of bacteria. Determining the pharmaceutical formulation confirms the purity of a substance. Many methods have been developed to determine the level of these substances. They involve mainly the following analytical techniques: chromatography, capillary electrophoresis, and spectroscopy. The separation techniques were combined with different measuring devices, such as ultraviolet (UV), fluorescence detector (FLD), diode array detector (DAD), and mass spectrometry (MS). The analytical procedures require proper sample pre-conditioning such as protein precipitation, extraction techniques, filtration, or dilution. This paper reviews the reported analytical methods for the determining representatives of the third and fourth generation of fluoroquinolones. Attention was paid to pre-conditioning of the samples and the applied mobile phase. This report might be helpful in the selection of the proper procedure in determining the abovementioned drugs in different matrices.Graphical abstract

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