Simultaneous determination of five phenolic components and paeoniflorin in rat plasma by liquid chromatography–tandem mass spectrometry and pharmacokinetic study after oral administration of Cerebralcare granule®

Wang, Xiangyang; Ma, Xiaojing; Li, Wei; Yang, Chong‐Ren; Guo, Jinqiu; Li, Shu-Ming; Wang, Junmei; Zhang, Hongchao; Zhou, Shuiping; Yu, Zhu

doi:10.1016/j.jpba.2013.07.042

Cited by 49 publications

(25 citation statements)

References 20 publications

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“…The incubation of anthocyanins with human gut microbiota confirmed the decomposition of anthocyanins to phenolic acids (Hidalgo et al, ). Then, 3,4‐dihydroxybenzoic acid could be absorbed by the gut microbiota and reached high amounts in plasma without further fermentation (Wang et al, ). In low concentrations, anthocyanins and phenolic acids can be transported in their native forms (Kuntz et al, ).…”

Section: Pharmacokinetics Of Grape Polyphenolsmentioning

confidence: 99%

Grapes (Vitis vinifera) as a Potential Candidate for the Therapy of the Metabolic Syndrome

Akaberi

Hosseinzadeh

2016

Phytotherapy Research

116

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Metabolic syndrome is associated with several disorders, including hypertension, diabetes, hyperlipidemia as well as cardiovascular diseases and stroke. Plant-derived polyphenols, compounds found in numerous plant species, play an important role as potential treatments for components of metabolic syndrome. Studies have provided evidence for protective effects of various polyphenol-rich foods against metabolic syndrome. Fruits, vegetables, cereals, nuts, and berries are rich in polyphenolic compounds. Grapes (Vitis vinifera), especially grape seeds, stand out as rich sources of polyphenol potent antioxidants and have been reported helpful for inhibiting the risk factors involved in the metabolic syndrome such as hyperlipidemia, hyperglycemia, and hypertension. There are also many studies about gastroprotective, hepatoprotective, and anti-obesity effects of grape polyphenolic compounds especially proanthocyanidins in the literature. The present study investigates the protective effects of grape seeds in metabolic syndrome. The results of this study show that grape polyphenols have significant effects on the level of blood glucose, lipid profile, blood pressure, as well as beneficial activities in liver and heart with various mechanisms. In addition, the pharmacokinetics of grape polyphenols is discussed. More detailed mechanistic investigations and phytochemical studies for finding the exact bioactive component(s) and molecular signaling pathways are suggested.

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Section: Pharmacokinetics Of Grape Polyphenolsmentioning

confidence: 99%

Grapes (Vitis vinifera) as a Potential Candidate for the Therapy of the Metabolic Syndrome

Akaberi

Hosseinzadeh

2016

Phytotherapy Research

116

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“…Pharmacokinetic studies of traditional Chinese medicine (TCM) can not only explain and predict useful events with regard to the efficacy and safety but can also help to appraise the rationality and compatibility of the prescriptions or herbs [13]. It is well known that the curative effects of the TCM are usually based on the synergistic effects of various constituents, hence, simultaneous determination of the main bioactive components in biological samples for a multi‐component pharmacokinetic research is essential.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of ferulic acid, paeoniflorin, and albiflorin in rat plasma by ultra‐high performance liquid chromatography with tandem mass spectrometry: Application to a pharmacokinetic study of Danggui‐Shaoyao‐San

Zhu

Guan

Zhang

et al. 2020

J of Separation Science

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A rapid, selective, and sensitive ultra-high performance liquid chromatographytandem mass spectrometry method was developed for simultaneous determination of ferulic acid, paeoniflorin, and albiflorin, the major active constituents of Danggui-Shaoyao-San, in rat plasma using geniposide as the internal standard. The plasma samples were processed by protein precipitation with acetonitrile, and then separated on a Shim-Pack XR-ODS C 18 column (75 mm × 3.0 mm, 2.2 μm) using gradient elution program with a mobile phase consisting of 0.1% aqueous formic acid and acetonitrile at a flow rate of 0.4 mL/min. The detection was achieved on a 3200 QTRAP mass spectrometer equipped with electrospray ionization source in negative ionization mode. Quantification was performed using multiple reaction monitoring mode by monitoring the fragmentation of m/z 192.9→134.0 for ferulic acid, m/z 525.0→120.9 for paeoniflorin, m/z 525.2→121.0 for albiflorin, and m/z 433.1→225.1 for the internal standard, respectively. The calibration curve was linear in the range of 5-2500 ng/mL for all the three analytes (r ≥ 0.9972) with the lower limit of quantitation of 5 ng/mL. The intraday and interday precisions were below 12.1% for all the analytes in terms of relative standard deviation, and the accuracy was within ±11.5% in terms of relative error. The extraction recovery, matrix effect and stability were satisfactory in rat plasma. The validated method was successfully applied to a pharmacokinetic study of ferulic acid, paeoniflorin, and albiflorin after oral administration of Danggui-Shaoyao-San to rats.

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“…Several methods for the quantification of CA in plasma by liquid chromatography/tandem mass spectrometry (LC/MS/MS) have been described. [8][9][10] However, only one method has been used to detect CA in human plasma with a complicated procedure for sample preparation. 10 In addition, no analytical method for the determination of CA in human urine using LC/MS/MS has been reported.…”

Section: Introductionmentioning

confidence: 99%

A new method of ultra‐performance liquid chromatography/tandem mass spectrometry for determination of chlorogenic acid in human plasma and urine

Han

Liu

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale Chlorogenic acid (CA) is well known for its various biological activities. Here, a clinical study was performed in patients with advanced malignant cancer to explore its therapeutic effects. We aimed to develop a method to quantify CA in human plasma and urine to assist the clinical pharmacokinetic study. Methods Ultra‐performance liquid chromatography (UPLC) coupled with a triple quadruple mass spectrometry was used to separate and detect CA, with puerarin serving as the internal standard. Results The method presents an excellent linearity ranging from 5 to 2000 ng/mL for plasma analysis and 50 to 20 000 ng/mL for urine analysis. Intra‐ and inter‐day precision and accuracy were both less than 15% for plasma and urine. Conclusions These results showed that the novel UPLC method was robust and sensitive, and fulfilled the requirements for a clinical pharmacokinetic study of CA in patients with advanced cancer.

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Simultaneous determination of five phenolic components and paeoniflorin in rat plasma by liquid chromatography–tandem mass spectrometry and pharmacokinetic study after oral administration of Cerebralcare granule®

Cited by 49 publications

References 20 publications

Grapes (Vitis vinifera) as a Potential Candidate for the Therapy of the Metabolic Syndrome

Grapes (Vitis vinifera) as a Potential Candidate for the Therapy of the Metabolic Syndrome

Simultaneous determination of ferulic acid, paeoniflorin, and albiflorin in rat plasma by ultra‐high performance liquid chromatography with tandem mass spectrometry: Application to a pharmacokinetic study of Danggui‐Shaoyao‐San

A new method of ultra‐performance liquid chromatography/tandem mass spectrometry for determination of chlorogenic acid in human plasma and urine

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