Simultaneous determination of dextromethorphan HBr and bromhexine HCl in tablets by first-derivative spectrophotometry

Tantishaiyakul, Vimon; Poeaknapo, Chotima; Sribun, P; Sirisuppanon, K

doi:10.1016/s0731-7085(97)00188-x

Cited by 34 publications

(9 citation statements)

References 8 publications

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“…The simultaneous estimation by RP-HPLC methods for Dextromethorphan [3][4][5][6][7][8][9][10] and Quinidine [11][12][13][14] with other drugs by RP-HPLC and other spectrometric methods were developed. The Simultaneous determination of Dextromethorphan and Quinidine by Fluorometric 15 method was studied but RP-HPLC and UV spectrometric methods for simultaneous estimation of these drugs were not available.…”

Section: Fig 2: Structure Of Quinidinementioning

confidence: 99%

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2017

IJPSR

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Objectives of study: To develop and validate new, rapid, selective, precise, accurate and economical, isocratic RP-HPLC and UV spectrophotometric method for simultaneous estimation of Dextromethorphan and Quinidine in bulk and in tablet formulations. Methods: A RP-HPLC was developed for the simultaneous estimation of Dextromethorphan and Quinidine on Phenomenex C-8 column with the mobile phase of methanol and phosphate buffer (pH 2.5) in the ratio 60:40 v/v at flow rate of 1ml/min and detection at 230nm was used for the study. In UV spectrometry, simultaneous equation method was based on measurement of absorbances at two selected wavelengths 278nm and 331nm for Dextromethorphan hydrobromide and Quinidine Sulfate respectively. Absorbance ratio method based on the measurement of absorbances at isobestic point and wavelength maxima of one drug, selected wavelengths were 278nm (λmax of DMH) and 289nm (isobestic point). The developed methods were validated and recovery studies were carried according to ICH guidelines. Results: The peaks of Dextromethorphan and Quinidine were found to be well resolved with retention time of 4.3min and 2.8min respectively, indicating the shorter analysis time. The proposed method was found to be accurate, precise and reproducible. The linearity was established in the concentration range of 1-30µg/ml. Limit of Detection (LOD) and Limit of Quantification (LOQ) were found to be within limits for both Dextromethorphan and Quinidine. In UV-spectrometry, both methods obey the Beer Lambert's law in the concentration range of 30-150μg/ml for Dextromethorphan Hydrobromide and 10-70μg/ml for Quinidine Sulfate respectively. Conclusion: The methods can be used for routine analysis of formulations containing any of the above drugs or combinations without any alteration in the chromatographic conditions.

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Section: Fig 2: Structure Of Quinidinementioning

confidence: 99%

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2017

IJPSR

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“…2 Different spectrophotometric methods have been reported for the determination of DXM in both the bulk drug and the dosage forms. [3][4][5][6][7][8][9][10] The first and second-derivative technique UV spectrophotometry, [11][12][13] thin-layer chromatography, New, simple and convenient potentiometric and spectrophotometric methods are described for the determination of dextromethorphan hydrobromide (DXM) in pharmaceutical preparations. The potentiometric technique is based on developing a potentiometric sensor incorporating the dextromethorphan tetrakis(p-chlorophenyl)borate ion-pair complex as an electroactive species in a plasticized PVC matrix membrane with o-nitophenyl octyl ether or dioctyl phthalate.…”

Section: Introductionmentioning

confidence: 99%

New Potentiometric and Spectrophotometric Methods for the Determination of Dextromethorphan in Pharmaceutical Preparations

Elmosallamy

Amin

2014

ANAL. SCI.

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“…15 Capillary electrophoresis 16,17 and multiwavelength and derivative spectrophotometry 18,19 have also been reported for the determinations of DXM. However, many of these methods require several time-consuming manipulation steps, sophisticated instruments and special training.…”

Section: Introductionmentioning

confidence: 99%

Polymeric Membrane Sensors for the Selective Determination of Dextromethorphan in Pharmaceutical Preparations

El-Naby

2008

ANAL. SCI.

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The construction and electrochemical response characteristics of poly(vinyl chloride) matrix ion-selective electrodes (ISEs) for dextromethorphan (DXM) hydrobromide are described. The membranes incorporate ion-association complexes of DXM with reineckate salt {[Cr(NH3)2(SCN)4]NH4} or phosphomolybdic acid [H3(PMo12O40)], as electroactive materials and dioctylphthalate or dibutylsebacate as a plasticizing solvent mediator. The sensors display a fast, stable and linear response with slopes of 54.4 to 59.5 mV/decade at pH 2.5 -6.5 and a detection limit of 1.0 ¥ 10 -6 M. Moreover, the sensors exhibit very good selectivity for DXM over opiate alkaloids, as well as organic and inorganic cations. The sensors proved to be useful for the determination of 5.0 ¥ 10 -5 -1.0 ¥ 10 -3 M DXM hydrobromide in pure as well as in dosage forms by direct potentiometry and standard addition methods. Determination of 5.0 ¥ 10 -4 M DXM using the standard addition method and a sensor based on phosphomolybdate and dioctylphthalate shows an average recovery of 99.8% and a relative standard deviation (RSD) of 0.4%.

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Simultaneous determination of dextromethorphan HBr and bromhexine HCl in tablets by first-derivative spectrophotometry

Cited by 34 publications

References 8 publications

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New Potentiometric and Spectrophotometric Methods for the Determination of Dextromethorphan in Pharmaceutical Preparations

Polymeric Membrane Sensors for the Selective Determination of Dextromethorphan in Pharmaceutical Preparations

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