Simultaneous determination of dantrolene and its metabolites, 5-hydroxydantrolene and nitro-reduced acetylated dantrolene (F 490), in plasma and urine of man and dog by high-performance liquid chromatography

Wuis, E.W.; Grutters, A.C.L.M.; Vree, T. B.; Kleyn, E. Van Der

doi:10.1016/s0378-4347(00)81864-2

Cited by 28 publications

(12 citation statements)

References 17 publications

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“…DAS was also determined either alone [13] or in presence of its metabolites and impurities [14,15] or in biological fluids [16,17]. Literature search revealed only one high performance liquid chromatographic method with UV detection (HPLC-UV) for the simultaneous determination of PAR and DAS in dosage form [18].…”

Section: Paracetamol (Par); N-acetyl-p-aminophenol;mentioning

confidence: 99%

Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form

et al. 2014

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KEYWORDSAccurate, precise and simple spectrophotometric methods have been developed and validated for the determination of paracetamol (PAR) and dantrolene sodium (DAS). Spectrophotometric methods including zero order, first derivative ( 1 D) and derivative ratio methods ( 1 DD) have been developed. The zero order spectrophotometric method was used for the determination of DAS in the range of 1-20 μg/mL by measuring the absorbance at 379 nm where PAR exhibits zero reading. 1 D and 1 DD methods were used for the determination of PAR in the range of 1.5-20.0 μg/mL by measuring the peaks amplitudes at 265.5 nm and 265.0 nm, respectively. The proposed methods were used to determine PAR in binary mixture with DAS in the laboratory prepared mixtures and in pharmaceutical dosage form. The results obtained were statistically evaluated and found to be accurate and precise and can be satisfactorily applied for the quality control analysis of the cited drugs.

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Section: Paracetamol (Par); N-acetyl-p-aminophenol;mentioning

confidence: 99%

Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form

et al. 2014

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“…18) The simple, fast, inexpensive and successful assay of dantrelax tablets by means of the described electroanalytical procedures without prior extraction of the drug are great advantages over the reported liquid chromatographic methods [2][3][4][5][6][7][8] which usually require complex and time-consuming pretreatment and extraction steps for removal of interferences prior to analysis of the drug. Moreover, the chromatographic methods usually require expensive reagents and equipment which are not economically feasible for routine analysis; in addition considerable skills are necessary to operate them successfully.…”

Section: )mentioning

confidence: 99%

“…Only few liquid chromatographic methods [2][3][4][5][6][7][8] were described for assay of dantrolene sodium in dosage form and biological fluids. The chromatographic methods usually necessitate sample pretreatment and time-consuming extraction steps prior to analysis of the drug.…”

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confidence: 99%

“…Square-Wave Voltammetry Procedure For optimizing a square-wave adsorptive cathodic stripping voltammetric (SW-AdCSV) procedure to assay of bulk dantrolene sodium, effects of pH of the electrolysis solution (2)(3)(4)(5)(6)(7)(8)(9)(10)(11), and the instrumental conditions namely: frequency f (10-100 Hz), scan increment Ds (2-10 mV) and pulse-amplitude a (10-50 mV) on the peak current intensity of 5ϫ10 Ϫ7 M dantrolene sodium following its preconcentration onto the HMDE by adsorptive accumulation at Ϫ0.30 V for 60 s were studied. A much developed peak current intensity and a sharper peak shape were achieved at fϭ100 Hz, Dsϭ10 mV, aϭ50 mV in a B-R universal buffer of pH 11 as a supporting electrolyte.…”

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confidence: 99%

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Electroreduction of the Muscle Relaxant Drug Dantrolene Sodium at the Mercury Electrode and Its Determination in Bulk Form and Pharmaceutical Formulation

Ghoneim

2007

CHEMICAL & PHARMACEUTICAL BULLETIN

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Dantrolene sodium (Chart 1) is the hemihepta hydrate of sodium salt of 1-[5-(4-nitrophenyl)furfulidene amino]imidazolidene-2,4-dione. It is a muscle relaxant reported to act by blocking muscle concentration beyond the neuromuscular junction.1) It is described for the symptomatic relief of muscular spasm due to condition such as stroke, multiple sclerosis, spinal cord injury and cerebral palsy. Dantrolene sodium is used also intravenously in the treatment of malignant hyperthermia. 1)Only few liquid chromatographic methods 2-8) were described for assay of dantrolene sodium in dosage form and biological fluids. The chromatographic methods usually necessitate sample pretreatment and time-consuming extraction steps prior to analysis of the drug. Moreover, these methods required expensive equipment and considerable skills are necessary to operate them successfully. Although no official analytical method for determination of dantrolene sodium is reported in British or the United States pharmacopoeia an official electrometric titration method for determination of the drug is available in the Japanese pharmacopoeia. Besides, no any information is available in the literature to date concerning the electroreduction of dantrolene sodium or its electroanalytical determination. Therefore, the present work aimed to study the electroreduction pathway of dantrolene sodium at the mercury electrode and to describe simple and precise electroanalytical procedures for its determination in bulk form and pharmaceutical formulation. ExperimentalInstrumentation A Sargent-Welech Polarograph Model 4001 (Fisher, U.S.A.) was used for the present polarographic measurements. The electrolysis cell was as that previously described by Meites. 9) Characteristics of the capillary of the dropping mercury electrode (DME) were: mϭ1.13 mg/s and tϭ3.36 s in a solution of 0.1 M KCl at open circuit conditions for a mercury height of 60 cm. A saturated calomel electrode was used as a reference electrode.Computer-controlled Electrochemical Analyzers Models 273A and 363A-PAR (Princeton Applied Research, Oak Ridge, TN, U.S.A.) controlled via 270/250-PAR software were used for the voltammetric measurements. An electrode assembly (303A-PAR) incorporated with a three-electrode configuration system comprising of a hanging mercury drop electrode (HMDE) or a dropping mercury electrode (DME) as a working electrode (surface areaϭ0.026 cm 2 ), an Ag/AgCl/KCl s reference electrode and a platinum wire auxiliary electrode, was used. A magnetic stirrer (305-PAR) and a stirring bar were used to provide the convective transport during the accumulation step.A potentiostat/galvanostat (Model 173-PAR) incorporated with a digital coulometer Model 179-PAR was used for controlled-potential electrolysis of dantrolene sodium solutions. The coulometric cell used was designed by Princeton Applied Research (PAR) Corporation to have a large electrode surface area to solution volume ratio as possible. A mercury pool as a working electrode, a saturated calomel electrode as a reference a...

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“…Literature review revealed that several electrochemical methods [4][5][6] and HPLC methods [7][8][9][10][11][12][13][14] have been reported for the determination of DNT either in pharmaceutical or biological samples. Degradation behavior of DNT was reported in different buffers and temperature [15].…”

Section: Introductionmentioning

confidence: 99%

Stability-Indicating Chromatographic Methods for the Determination of a Skeletal Muscle Relaxant and an Analgesic in their Combined Dosage Form

Ys¹,

Sm²,

Am³

et al. 2016

J Chromatogr Sep Tech

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Simultaneous determination of dantrolene and its metabolites, 5-hydroxydantrolene and nitro-reduced acetylated dantrolene (F 490), in plasma and urine of man and dog by high-performance liquid chromatography

Cited by 28 publications

References 17 publications

Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form

Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form

Electroreduction of the Muscle Relaxant Drug Dantrolene Sodium at the Mercury Electrode and Its Determination in Bulk Form and Pharmaceutical Formulation

Stability-Indicating Chromatographic Methods for the Determination of a Skeletal Muscle Relaxant and an Analgesic in their Combined Dosage Form

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