Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry

Voltammetric behavior and quantification of the sedative-hypnotic drug chlordiazepoxide in bulk form, pharmaceutical formulation and human serum at a mercury electrode

“…The procedure did not require any time-consuming extraction or evaporation steps prior to the assay of the drug. The obtained results were favorably compared to those obtained by a reported spectrophotometric method [4].…”

“…Several analytical methods were described for the determination of chlordiazepoxide in pharmaceutical formulations and plasma samples. These include spectrophotometry [4][5][6][7][8], spectrofluorimetry [9,10] reversed-phase high-performance liquid chromatography [11][12][13][14][15][16][17], high-performance thin layer chromatography [18], thin layer chromatography [19], liquid chromatography [20,21] and reduction by zinc or cadmium in a continuous system followed by atomic-absorption spectrometric detection [22].…”

“…Because the presence of phenyl rings, benzodiazepines have surface activity and are readily adsorbed onto mercury surface, it is, therefore, not surprising that among other methods that were used to determination of bezodiazepines [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] the electrochemical techniques using a mercury electrode seems to be efficient not only for solution studies but also for quantitative determination [23,24].…”

“…Most of the reported methods [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] to determination of chlordiazepoxide required pretreatment and time-consuming extraction or evaporation steps prior to the analysis, which considered as disadvantages of the trace analysis methods. Furthermore, the reported polarographic procedures [30][31][32][33][34] for determination of the drug in pharmaceutical formulation and toxicological samples are not sufficiently sensitive for convenient application to human biological fluids.…”

Microencapsulamento de hidrolisados de caseína em lipoesferas para mascarar o sabor amargo: avaliação físico-química e sensorial

“…As equações das retas e os coeficientes de correlação foram, respectivamente, para os hirolisados H1, H2 e H3: y = 39,155x -0,5592, r Não foram encontrados dados na literatura com relação à medida da taxa de encapsulamento de hidrolisados protéicos em lipoesferas. Além disso, os dados disponí-veis indicam que a EDS somente foi utilizada até o presente para a determinação desta taxa no caso de clordiazepóxido, brometo de clidínio e brometo de oxifenônio em formulações farmacêuticas (Funasaki et al, 1999;Toral et al, 1999). O emprego desta técnica no presente trabalho justifica-se pelo fato de já ter sido utilizada na análise de hidrolisados de caseína, tendo apresentado resultados de grande interesse prático (Silvestre et al, 1993).…”