Simultaneous Determination of Carbamazepine and its Active Metabolite Carbamazepine-10,11-epoxide in Human Plasma by UPLC

Simultaneous Determination of Carbamazepine and Carbamazepine-10,11-epoxide in Different Biological Matrices by LC-MS/MS

“…19 However, a very similar method based on ultra performance liquid chromatography (UPLC) with UV-detection (UPLC-UV) was reported earlier for the quantification of the analytes in humans. 20 Still, there is a need to improve the turnout of the aforementioned methods. Thus, in the present work, we proposed to further simplify the sample preparation procedures and increase the throughput of the chromatographic method by also reducing analysis time.…”

Quantification of carbamazepine and its active metabolite by direct injection of human milk serum using liquid chromatography tandem ion trap mass spectrometry

“…Their use during breastfeeding is generally considered safe; however, observation for adverse effects is recommended. In the plasma, the half-life elimination of the unchanged drug is approximately 36 h following a single oral dose [8,9]. In addition, the major metabolite carbamazepine 10,11-epoxide (CBZE) has similar pharmacological activity and may be partly responsible for the side effects of the therapy [10,11].…”

“…The sample clean-up procedures used in these works were solid phase extraction (SPE), protein precipitation (PP) and liquid-liquid extraction (LLE) [9,11,12].…”

Determination of carbamazepine in human urine and serum samples by high‐performance liquid chromatography with post‐column Ru(bipy)‐Ce(SO4)2 chemiluminescence detection

“…There are other methods for the determination of CBZ in pharmaceutical tablets or biological samples such as ultra performance liquid chromatography (UPLC), Micellar Electrokinetic Chromatography (MEKC), etc. (13)(14)(15)(16). To achieve good selectivity and sensitivity, various separation techniques have been combined with a highly sensitive detection method (17)(18)(19)(20).…”