Simultaneous determination of caffeic acid derivatives by UPLC–MS/MS in rat plasma and its application in pharmacokinetic study after oral administration of Flos Lonicerae–Fructus Forsythiae herb combination

Shan, Jinjun; Wang, Shouquan; Ju, Wenzheng; Meng, Minxin; Cai, Baochang; Di, Liuqing

doi:10.1016/j.jchromb.2013.12.035

Cited by 28 publications

(19 citation statements)

References 20 publications

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“…Compounds 19 and 20 , with the pseudomolecular ion at m/z 755, generated some additional fragment ions as compared to verbascoside, due to the presence of a pentosyl unit in their structure. Depending on the pentose nature, these compounds could be assigned to forsythoside B/F (apiose/xylose) or angoroside A (arabinose) . Peak 27 was characterised as eukovoside: parent ion at m/z 637 and fragment ions at m/z 491 [(M‐H)‐rhamnosyl] − , 461 [(M‐H)‐feruloyl] − , 315 [(M‐H)‐feruloyl‐rhamnosyl] − , 193 [ferulate] − and 175 [anhydro‐ferulate] −.…”

Section: Resultsmentioning

confidence: 99%

HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS profiling of Verbascum ovalifolium Donn ex Sims and evaluation of its antioxidant and cytogenotoxic activities

Luca

Aprotosoaie

Mihai

et al. 2018

Phytochemical Analysis

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Section: Resultsmentioning

confidence: 99%

HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS profiling of Verbascum ovalifolium Donn ex Sims and evaluation of its antioxidant and cytogenotoxic activities

Luca

Aprotosoaie

Mihai

et al. 2018

Phytochemical Analysis

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“…The ACQUITY UPLC R HSS T3 C 18 column allows the analyte to easily enter the pore structure of the granular support material, and provides balanced retention for polar and hydrophobic molecules. It has therefore been widely used for separation of multiple components (including the complex components of traditional Chinese Medicine) [29][30][31]. In this work, the use of this column also provided better peak shapes and a relatively short retention time (shown in Fig.…”

Section: Optimization Of Chromatographic Conditionsmentioning

confidence: 96%

Determination of sophoraflavanone G and kurarinone in rat plasma by UHPLC–MS/MS and its application to a pharmacokinetic study

Yang

Zhang

et al. 2016

J of Separation Science

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This study aimed to develop and validate a simple and sensitive ultra high performance liquid chromatography tandem mass spectrometry method for the simultaneous determination of sophoraflavanone G and kurarinone in rat plasma by using rutin as the internal standard. Then, the developed method was applied to investigate the pharmacokinetics of sophoraflavanone G and kurarinone in rats after dosing the flavonoid extract from Sophora flavescens. Plasma samples were processed using a liquid-liquid extraction procedure with ethyl acetate. The analysis was performed on a triple quadrupole tandem mass spectrometer by multiple reaction monitoring with an electrospray ionization source in negative ionization mode. Quantitative ion transitions of m/z 423.2→161.2, 437.2→161.1, and 609.3→300.3 were monitored for sophoraflavanone G, kurarinone, and rutin, respectively. The calibration curves of the two analytes exhibited good linearity (r >0.9923) over the range of 0.1-200 ng/mL for sophoraflavanone G and 0.1-1000 ng/mL for kurarinone. Relative standard deviations were less than 13.2% for the intra- and inter-day precisions and no more than 12.6% for the recovery, showing good precision and satisfactory accuracy of the developed method. The validated method was successfully applied to the pharmacokinetic study of sophoraflavanone G and kurarinone after a single intravenous (25 mg/kg) and oral (500 mg/kg) administration of the flavonoid extract from S. flavescens, and the absolute bioavailability for sophoraflavanone G and kurarinone was about 36 and 17%, respectively.

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“…However, very little attention has been devoted to the pharmacokinetic studies of neochlorogenic acid and cryptochlorogenic acid; only Zhou et al . have developed an UPLC‐MS method to determine phenolic acids in rat plasma (Zhou et al ., , ). With regard to the Reduning injection, only chlorogenic acid and geniposide have ever been reported in pharmacokinetic studies (Bi et al ., ).…”

Section: Introductionmentioning

confidence: 97%

“…Several analytical methods for the determination of chlorogenic acid or geniposide in rat plasma have been described in the literature (Ye et al, 2012;Peng et al, 2013;Yu et al, 2013;Qu et al, 2013). However, very little attention has been devoted to the pharmacokinetic studies of neochlorogenic acid and cryptochlorogenic acid; only Zhou et al have developed an UPLC-MS method to determine phenolic acids in rat plasma (Zhou et al, 2013(Zhou et al, , 2014. With regard to the Reduning injection, only chlorogenic acid and geniposide have ever been reported in pharmacokinetic studies (Bi et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and geniposide in rat plasma by UPLC‐MS/MS and its application to a pharmacokinetic study after administration of Reduning injection

Wang

Wen

Zheng

et al. 2014

Biomedical Chromatography

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A simple, specific and sensitive ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was established and validated for simultaneous determination of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and geniposide in rat plasma using puerarin as an internal standard (IS). Plasma samples were pretreated by a one-step direct protein precipitation procedure with acetonitrile after acidified using as little as 50 μL plasma. Chromatographic separation was performed on an Acquity BEH C18 column (100 × 2.1 mm, 1.7 µm) at a flow rate of 0.2 mL/min by a gradient elution, using 0.2% acetic acid-methanol as mobile phase. The detection was performed on a triple quadrupole tandem mass spectrometer by multiple reaction monitoring via electrospray ionization source with negative ion mode. Calibration curves showed good linearity (r > 0.995) over wide concentration ranges. The intra- and inter-day precisions were <15%, and the accuracy was within ±8.0%. The validated method was successfully applied to a pharmacokinetic study of the four bioactive components in rats after intravenous administration of Reduning injection.

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Simultaneous determination of caffeic acid derivatives by UPLC–MS/MS in rat plasma and its application in pharmacokinetic study after oral administration of Flos Lonicerae–Fructus Forsythiae herb combination

Cited by 28 publications

References 20 publications

HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS profiling of Verbascum ovalifolium Donn ex Sims and evaluation of its antioxidant and cytogenotoxic activities

HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS profiling of Verbascum ovalifolium Donn ex Sims and evaluation of its antioxidant and cytogenotoxic activities

Determination of sophoraflavanone G and kurarinone in rat plasma by UHPLC–MS/MS and its application to a pharmacokinetic study

Simultaneous determination of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and geniposide in rat plasma by UPLC‐MS/MS and its application to a pharmacokinetic study after administration of Reduning injection

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