Simultaneous determination of bromhexine hydrochloride and methyl and propyl p-hydroxybenzoate and determination of dextromethorphan hydrobromide in cough-cold syrup by high-performance liquid chromatography

Rauha, Jussi-Pekka; Salomies, Hannele; Aalto, Marja

doi:10.1016/0731-7085(96)01846-8

Cited by 34 publications

(16 citation statements)

References 10 publications

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“…It may be a new drug for the morbidity of chronic pancreatitis, in which there is increased viscosity of the pancreatic juice and formation of a protein plug (1). Although some methods have been developed for the determination of bromhexine hydrochloride, such as spectrophotometry (2,3), near-infrared spectroscopy (4) and chromatography (5)(6)(7)(8)(9)(10), the limitation to these methods is low sensitivity or expensive instrumentation. To the best of our knowledge, a CL method has not yet been reported for the determination of bromhexine hydrochloride.…”

Section: Introductionmentioning

confidence: 99%

Chemiluminescence determination of bromhexine hydrochloride with morin as chemiluminescent reagent

Jiang

Nie

2008

Luminescence

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A new chemiluminescence (CL) reaction was observed when cerium(IV) solution was injected into bromhexine hydrochloride-morin solution. Based on this, a flow-injection CL method for the determination of bromhexine hydrochloride was established. A possible mechanism of the CL reaction was proposed via the investigation of the CL kinetic characteristics, the CL spectrum and the fluorescence spectra of some related substances. Under optimum conditions, the CL signal was correlated linearly with concentration of bromhexine hydrochloride over the range 2.0 x 10(-9)-2.0 x 10(-7) g/mL, with a linear correlation of 0.9995. The detection limit was 9 x 10(-10) g/mL bromhexine hydrochloride and the relative standard deviation was 1.0% (c = 2.0 x 10(-8) g/mL bromhexine hydrochloride, n = 11). The method was applied to the determination of bromhexine hydrochloride in pharmaceutical preparations and human urine samples with satisfactory results.

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Section: Introductionmentioning

confidence: 99%

Chemiluminescence determination of bromhexine hydrochloride with morin as chemiluminescent reagent

Jiang

Nie

2008

Luminescence

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“…Gas chromatography (GC) and liquid chromatography (LC) coupled with various detectors were frequently employed for the determination of PHBs []. Because of the fact that most PHBs are nonvolatile and polar compounds, LC with C18 column becomes the most frequently used separation platform for PHBs.…”

Section: Introductionmentioning

confidence: 99%

Development of magnetic multiwalled carbon nanotubes as solid‐phase extraction technique for the determination of p‐hydroxybenzoates in beverage

Huang¹,

Fu²,

Li³

et al. 2012

J of Separation Science

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In this work, magnetic multiwalled carbon nanotubes were synthesized through a facile hydrothermal process, and then successfully used as magnetic solid-phase extraction sorbents for the determination of p-hydroxybenzoates in beverage. The prepared magnetic multiwalled carbon nanotubes presented both satisfactory superparamagnetism and strong capacity of absorption, with magnetic Fe(3)O(4) beads of 200 nm average diameters decorated at either ends of the tubes. The hybrid nanocomposites showed a high efficiency in the extraction and enrichment of p-hydroxybenzoates via π-π stacking of targeted molecules onto the polyaromatic composed surface of multiwalled carbon nanotubes, which entitled them promising magnetic solid-phase extraction sorbents for p-hydroxybenzoates at trace level from complex drink samples. By using an external magnetic field, p-hydroxybenzoates adsorbed on magnetic multiwalled carbon nanotubes could be rapidly isolated in only 30 s, and subsequently analyzed by liquid chromatography-diode array detector after elution with organic solvents. Extraction conditions such as eluting solvent, the amounts of magnetic sorbents added, pH values, adsorption and desorption time were investigated and optimized to achieve the best effect. Method validations including linearity, detection limit, and precision were also studied. The linearities were in the wide range of 0.05-500 μg/mL with correlation coefficients higher than 0.9983 for all p-hydroxybenzoates. The limits of detection were less than 20 ng/mL. Acceptable RSDs were achieved within 5-8% for all analytes. The results indicated that the proposed method based on magnetic multiwalled carbon nanotubes as magnetic solid-phase extraction absorbents was rapid, efficient, and convenient for the analysis of the targeted compounds of p-hydroxybenzoates in beverage sample.

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“…BX was determined using absorption spectrophotometry and PLS multivariate calibration [14,15]. HPLC was used for determination of multicomponent mixtures containing BX with ambroxol hydrochloride and clenbuterol [16], sulfamethoxypyridazine, sulfamethoxazole, sulfadimethoxine and trimethoprim [17], promethazine hydrochloride, noscapine hydrochloride, ephedrine hydrochloride [18], methylparaben and propylparaben [19], clorprenaline and decloxizine [20,21].…”

Section: Introductionmentioning

confidence: 99%

Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs

El‐Gindy

Emara

Shaaban

2007

Journal of Pharmaceutical and Biomedical Analysis

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Simultaneous determination of bromhexine hydrochloride and methyl and propyl p-hydroxybenzoate and determination of dextromethorphan hydrobromide in cough-cold syrup by high-performance liquid chromatography

Cited by 34 publications

References 10 publications

Chemiluminescence determination of bromhexine hydrochloride with morin as chemiluminescent reagent

Chemiluminescence determination of bromhexine hydrochloride with morin as chemiluminescent reagent

Development of magnetic multiwalled carbon nanotubes as solid‐phase extraction technique for the determination of p‐hydroxybenzoates in beverage

Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs

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