Simultaneous determination of blonanserin and its metabolite in human plasma and urine by liquid chromatography–tandem mass spectrometry: Application to a pharmacokinetic study

Yao, Wen; Ni, Xiao; Zhang, Ming; Liu, Xia; Shang, Dewei

doi:10.1016/j.jchromb.2012.06.037

Cited by 19 publications

(16 citation statements)

References 13 publications

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“…The intra‐day and inter‐day precision and relative errors were less than 8.03% and 6.55% for the three QC levels in plasma. The current LC‐MS/MS method was validated, proved to be simple, sensitive, and accurate, and has been successfully applied to investigate the PKs of blonanserin in human subjects (Ogawa et al ., ; Wen et al ., ).…”

Section: Participants and Methodsmentioning

confidence: 97%

Population pharmacokinetics of blonanserin in Chinese healthy volunteers and the effect of the food intake

Yao

Shang

Xie

et al. 2013

Human Psychopharmacology

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Section: Participants and Methodsmentioning

confidence: 97%

Population pharmacokinetics of blonanserin in Chinese healthy volunteers and the effect of the food intake

Yao

Shang

Xie

et al. 2013

Human Psychopharmacology

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“…To date procedures for determination of blonanserin [11][12][13][14][15] along with is degradant product [16][17][18][19] and in biometrics [20][21][22][23] using HPLC had been reported. In addition to this GC method for residual solvent 24,25 determination in blonanserin and blonanserin determination in human plasma 26 In addition to this Kalariya et al stated that blonanserin is thermally stable.…”

Section: Fig 1: Chemical Structure Of Blonanserinmentioning

confidence: 99%

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2017

IJPSR

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Paper presents a novel high performance liquid chromatography method development, optimization, validation and application of determining blonanserin in bulk drug, its formulation, human serum and in the presence of its degradation products. Selection of important factors which may influence separation were concluded: percentage of acetonitrile in the mobile phase, the percentage of orthophosphoric acid in aqueous phase and flow rate. Factors selected were altered in accordance to Box-Behnken design plan and investigation in factors having significant influence on separation were executed. Finally, the choicest values from solution offered of investigated factors were 43 % of acetonitrile in the mobile phase, 0.03% orthophosphoric acid in water and flowrate of 0.75 ml/min. The method validation was performed according to International Conference on Harmonisation guideline acceptance criteria for robustness, linearity, selectivity, precision and accuracy. Quantitative and qualitative system responses have not significantly affected by little variations in chromatographic parameters, which demonstrates robustness of the method. Limits of quantification and detection for blonanserin was calculated. Method shows excellent linearity, which was confirmed by r 2 = 0.9991 over the concentration range of 5 -50 µg/ml. Accuracy was calculated by recovery experiment and found to be in range 99.44-100.76 %. Precision was carried out at different levels: analysis repeatability, injection repeatability and intermediate precision and was found well under acceptable criteria. Furthermore, the applicability of method was analysed in real time sample analysis of blonanserin in its commercial pharmaceutical preparations and in-vitro human serum samples.

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“…Observed values were calculated based on each accompanying calibration curve. Accuracy is represented as deviation, which is defined as the mean observed QC concentration minus the nominal concentration divided by the nominal concentration and multiplied by 100 [15]. The mean, as well as the SD, were evaluated following recommendations published by the FDA.…”

Section: Precision and Accuracymentioning

confidence: 99%

A Rapid LC–MS/MS Quantification of Peramivir Using A Simple and Inexpensive Sample Precipitation: Application to Pk

et al. 2015

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Simultaneous determination of blonanserin and its metabolite in human plasma and urine by liquid chromatography–tandem mass spectrometry: Application to a pharmacokinetic study

Cited by 19 publications

References 13 publications

Population pharmacokinetics of blonanserin in Chinese healthy volunteers and the effect of the food intake

Population pharmacokinetics of blonanserin in Chinese healthy volunteers and the effect of the food intake

Untitled

A Rapid LC–MS/MS Quantification of Peramivir Using A Simple and Inexpensive Sample Precipitation: Application to Pk

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