Simultaneous Determination of Ascorbic Acid, Pyridoxine Hydrochloride, and Tyrosine by Derivative UV Spectrophotometry

Surmeian, Mariana

doi:10.3109/03639049809082374

Cited by 15 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Wedina et al applied solid-phase UV spectrophotometer technique to measure ascorbic acid [13]. M. Surmeian described new method for resolving three-component drug mixture [14]. H.F. Ji and E. L. Shen studied quenching mechanisms of triplet state riboflavin by vitamin C [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Uv-Vis, NMR and Ft-Ir Spectra of Tautomers of Vitamin C. Experimental and DFT Calculations

Dabbagh

Azami

Farrokhpour

et al. 2014

J. Chil. Chem. Soc.

View full text Add to dashboard Cite

Experimental and computational analysis of spectroscopic parameters of L-ascorbic acid (vitamin C) and its tautomers was investigated by Density Functional Theory (DFT) using B3LYP method. The optimized geometries and calculated vibrational frequencies were evaluated. The latter was compare with those of experimental values. The λ max values of L-ascorbic acid were found 259 (at pH = 3) experimentally, 238 and 247 nm calculated in the gas and water phase at TD-DFT methods, respectively.

show abstract

Section: Introductionmentioning

confidence: 99%

Uv-Vis, NMR and Ft-Ir Spectra of Tautomers of Vitamin C. Experimental and DFT Calculations

Dabbagh

Azami

Farrokhpour

et al. 2014

J. Chil. Chem. Soc.

View full text Add to dashboard Cite

show abstract

“…However, dissolution data acquisition and construction of dissolution profiles is a laborious, repetitive, and often time consuming process, especially in the case of mixtures of analytes; therefore, much effort toward automation and increase of analytical speed has been reported, including the use of automated sample management [22], fiber optic technology [23] and diode array detection [24], usually combined with derivative spectroscopy [25], which have shown to favourably compete with HPLC in the determination of the dissolution profile of binary mixtures [26,27]. There are only scattered references to chemometric methods with minimum sample pre-treatment and high sample throughput being associated with the dissolution test.…”

Section: External Validationmentioning

confidence: 99%

Chemometrics-assisted simultaneous determination of atenolol and chlorthalidone in synthetic binary mixtures and pharmaceutical dosage forms

Ferraro

Castellano

Kaufman

2003

Analytical and Bioanalytical Chemistry

View full text Add to dashboard Cite

Resolution of binary mixtures of atenolol (ATE) and chlorthalidone (CTD) with minimum sample pre-treatment and without analyte separation has been successfully achieved, using a new and rapid method based on partial least squares (PLS1) analysis of UV spectral data. The simultaneous determination of both analytes was possible by PLS1 processing of sample absorbances between 255 and 300 nm for ATE and evaluation of absorbances in the 253-268 nm region for CTD. The mean recoveries for synthetic samples were 100.3 +/- 1.0% and 100.7 +/- 0.7% for ATE and CTD, respectively. Application of the proposed method to two commercial tablet preparations in the content uniformity test showed them to contain 103.5 +/- 0.8% and 104.9 +/- 1.8% ATE respectively, as well as 103.4 +/- 1.2% and 104.5 +/- 2.2% CTD. Use of this method also allowed the elaboration of dissolution profiles of the drugs in two commercial combined formulation products, through the simultaneous determination of both drugs during the dissolution test. At the dissolution time of 45 min specified by USP XXIV, both pharmaceutical formulations complied with the test.

show abstract

“…Several analytical methods have been reported for the determination of DOX or PYR or FA either alone or in combination with other drugs, using HPLC89, HPTLC10, UV 11–16, spectrofluorometric determination1718, capillary electrophoresis19 and flow injection20. These methods have not been studied for use in the simultaneous determination of DOX, PYR, and FA.…”

mentioning

confidence: 99%

Simultaneous derivative spectrophotometric analysis of doxylamine succinate, pyridoxine hydrochloride and folic acid in combined dosage forms

Pathak

Rajput

2008

Indian J Pharm Sci

View full text Add to dashboard Cite

Two UV spectrophotometric methods have been developed, based on first derivative spectrophotometry for simultaneous estimation of doxylamine succinate, pyridoxine hydrochloride, and folic acid in tablet formulations. In method I, the concentrations of these drugs were determined by using linear regression equation. Method II is also based on first derivative spectrophotometry however simultaneous equations (Vierdot's method) were derived on derivative spectra. The first derivative amplitudes at 270.0, 332.8 and 309.2 nm were utilized for simultaneous estimation of these drugs respectively by both methods. In both the methods, linearity was obtained in the concentration range 2.5-50 μg/ml, 1-40 μg/ml and 1-30 μg/ml for doxylamine succinate, pyridoxine hydrochloride, and folic acid respectively. The developed methods show best results in terms of linearity, accuracy, precision, LOD, LOQ and ruggedness for standard laboratory mixtures of pure drugs and marketed formulations. The common excipients and additives did not interfere in their determinations.

show abstract

Simultaneous Determination of Ascorbic Acid, Pyridoxine Hydrochloride, and Tyrosine by Derivative UV Spectrophotometry

Cited by 15 publications

References 16 publications

Uv-Vis, NMR and Ft-Ir Spectra of Tautomers of Vitamin C. Experimental and DFT Calculations

Uv-Vis, NMR and Ft-Ir Spectra of Tautomers of Vitamin C. Experimental and DFT Calculations

Chemometrics-assisted simultaneous determination of atenolol and chlorthalidone in synthetic binary mixtures and pharmaceutical dosage forms

Simultaneous derivative spectrophotometric analysis of doxylamine succinate, pyridoxine hydrochloride and folic acid in combined dosage forms

Contact Info

Product

Resources

About