Simultaneous determination of ascorbic acid, dopamine, and uric acid with polyaniline/hemin/reduced graphite oxide composite

Aryal, Krishna; Jeong, Hae Kyung

doi:10.1016/j.cplett.2021.138405

Cited by 25 publications

(18 citation statements)

References 28 publications

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“…In particular, we developed a simple process divided into two very short stages (first stage: deposition of rGO; second stage: deposition of PANI), which allows obtaining a double-layer electrode quickly and easily. In the vast majority of the literature data, rGO/PANI electrodes are obtained with different methods (chemical, hydrothermal, in situ polymerization) that are more complicated and time-consuming and which also require numerous reagents [63][64][65][66]. The only paper comparable to ours is that of Xue et al [67], where, however, the electrode preparation procedure is really long and complex compared to the one proposed by us.…”

Section: Introductionmentioning

confidence: 83%

PANI-Based Wearable Electrochemical Sensor for pH Sweat Monitoring

et al. 2021

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Nowadays, we are assisting in the exceptional growth in research relating to the development of wearable devices for sweat analysis. Sweat is a biofluid that contains useful health information and allows a non-invasive, continuous and comfortable collection. For this reason, it is an excellent biofluid for the detection of different analytes. In this work, electrochemical sensors based on polyaniline thin films deposited on the flexible substrate polyethylene terephthalate coated with indium tin oxide were studied. Polyaniline thin films were abstained by the potentiostatic deposition technique, applying a potential of +2 V vs. SCE for 90 s. To improve the sensor performance, the electronic substrate was modified with reduced graphene oxide, obtained at a constant potential of −0.8 V vs. SCE for 200 s, and then polyaniline thin films were electrodeposited on top of the as-deposited substrate. All samples were characterized by XRD, SEM, EDS, static contact angle and FT-IR/ATR analysis to correlate the physical-chemical features with the performance of the sensors. The obtained electrodes were tested as pH sensors in the range from 2 to 8, showing good behavior, with a sensitivity of 62.3 mV/pH, very close to a Nernstian response, and a reproducibility of 3.8%. Interference tests, in the presence of competing ions, aimed to verify the selectivity, were also performed. Finally, a real sweat sample was collected, and the sweat pH was quantified with both the proposed sensor and a commercial pH meter, showing an excellent concordance.

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Section: Introductionmentioning

confidence: 83%

PANI-Based Wearable Electrochemical Sensor for pH Sweat Monitoring

et al. 2021

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“…Selective detection of DA and its coexisting neurochemicals such as AA and UA has been a critical, widely debated, and an old question in neuroelectrochemistry. , Various research papers have been published on selective detection of dopamine by using negatively charged membranes or coatings of materials such as Nafion, polypyrrole, laccase, and polyaniline by utilizing their cationic permeability. − Similarly, pretreatment and various modifications of electrodes have been performed to achieve selective dopamine sensing. , Differential pulse voltammetry has also been utilized as a means to show potential shifts, thus maximizing the peak separation among DA, UA, and AA. , However, there are challenges associated with these methods such as slow measurements with DPV, slow response time, reproducibility and stability of the electrode coatings, ill-defined fabrication procedures, and lack of control over the modified electrodes. In this work, we propose to replace these complex and challenging modification methods with a simple but accurate control of CNF lengths.…”

Section: Introductionmentioning

confidence: 99%

“… 13 , 14 Various research papers have been published on selective detection of dopamine by using negatively charged membranes or coatings of materials such as Nafion, polypyrrole, laccase, and polyaniline by utilizing their cationic permeability. 15 − 18 Similarly, pretreatment and various modifications of electrodes have been performed to achieve selective dopamine sensing. 19 , 20 Differential pulse voltammetry has also been utilized as a means to show potential shifts, thus maximizing the peak separation among DA, UA, and AA.…”

Section: Introductionmentioning

confidence: 99%

Modulating the Geometry of the Carbon Nanofiber Electrodes Provides Control over Dopamine Sensor Performance

et al. 2023

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One of the major challenges for in vivo electrochemical measurements of dopamine (DA) is to achieve selectivity in the presence of interferents, such as ascorbic acid (AA) and uric acid (UA). Complicated multimaterial structures and ill-defined pretreatments have been frequently utilized to enhance selectivity. The lack of control over the realized structures has prevented establishing associations between the achieved selectivity and the electrode structure. Owing to their easily tailorable structure, carbon nanofiber (CNF) electrodes have become promising materials for neurobiological applications. Here, a novel yet simple strategy to control the sensitivity and selectivity of CNF electrodes toward DA is reported. It consists of adjusting the lengths of CNF by modulating the growth phase during the fabrication process while keeping the surface chemistries similar. It was observed that the sensitivity of the CNF electrodes toward DA was enhanced with the increase in the fiber lengths. More importantly, the increase in the fiber length induced (i) an anodic shift in the DA oxidation peak and (ii) a cathodic shif t in the AA oxidation peak. As the UA oxidation peak remained unaffected at high anodic potentials, the electrodes with long CNFs showed excellent selectivity. Electrodes without proper fibers showed only a single broad peak in the solution of AA, DA, and UA, completely lacking the ability to discriminate DA. Hence, the simple strategy of controlling CNF length without the need to carry out any complex chemical treatments provides us a feasible and robust route to fabricate electrode materials for neurotransmitter detection with excellent sensitivity and selectivity.

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“…The performance characteristics of other recently reported electrochemical sensors for DA detection are summarized in Table I (73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90).…”

Section: Elect Rochemical Sensors For Dopa Mine Analysismentioning

confidence: 99%

Actualities in immunological markers and electrochemical sensors for determination of dopamine and its metabolites in psychotic disorders (Review)

et al. 2021

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Psychotic disorders represent a serious health concern. At this moment, anamnestic data, international criteria for diagnosis/classification from the Diagnostic and Statistical Manual of Mental Disorders-5 and the International Classification of Diseases-10 and diagnostic scales are used to establish a diagnosis. The most commonly used biomarkers in psychotic illnesses are those regarding the neuroimmune system, metabolic abnormalities, neurotrophins and neurotransmitter systems and proteomics. A current issue faced by clinicians is the lack of biomarkers to help develop a more accurate diagnosis, with the possibility of initiating the most effective treatment. The detection of biological markers for psychosis has the potential to contribute to improvements in its diagnosis, prognosis and treatment effectiveness. The mixture of multiple biomarkers may improve the ability to differentiate and classify these patients. In this sense, the aim of this study was to analyze the literature concerning the potential biomarkers that could be used in medical practice and to review the newest developments in electrochemical sensors used for dopamine detection, one of the most important exploited biomarkers.

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Simultaneous determination of ascorbic acid, dopamine, and uric acid with polyaniline/hemin/reduced graphite oxide composite

Cited by 25 publications

References 28 publications

PANI-Based Wearable Electrochemical Sensor for pH Sweat Monitoring

PANI-Based Wearable Electrochemical Sensor for pH Sweat Monitoring

Modulating the Geometry of the Carbon Nanofiber Electrodes Provides Control over Dopamine Sensor Performance

Actualities in immunological markers and electrochemical sensors for determination of dopamine and its metabolites in psychotic disorders (Review)

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