Simultaneous determination of ascorbic acid and dopamine in the presence of uric acid on ruthenium oxide modified electrode

Piraman, Shakkthivel; Chen, Shen‐Ming

doi:10.1016/j.bios.2006.07.026

Cited by 153 publications

(36 citation statements)

References 27 publications

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“…In most of this work the overlapping DA, AA and UA peak currents have been separated using a modified electrode, while this method solves the problem by using a conventional glassy carbon electrode and applying PLSR. The method shows a higher sensitivity than some methods [8,23,27] or moderately less than others [1,19,37,40]. The limit of detection (LOD) of the method was 0.4 µM dopamine, comparable with the reported methods.…”

Section: Resultssupporting

confidence: 70%

“…The concentration of AA is generally much higher than that of DA (100 to 1000 times) [12]. UA and AA also coexist in biological fluids, such as blood and urine [19]. The significant problem encountered with the detection of DA arising from the low concentration levels of DA and the primary interference from AA (0.2-0.4 mM) and UA, which largely co-exist with DA and have overlapping voltammetric response at bare electrodes.…”

Section: Introductionmentioning

confidence: 99%

“…Electrochemical methods have been widely used for determination of DA in the presence of AA and UA. All require modification of the electrode surface [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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Voltammetric determination of dopamine in the presence of ascorbic and uric acids using partial least squares regression: determination of dopamine in human urine and plasma

2009

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Abstract:A new differential pulse voltammetric method for dopamine determination at a bare glassy carbon electrode has been developed. Dopamine, ascorbic acid (AA) and uric acid (UA) usually coexist in physiological samples. Because AA and UA can be oxidized at potentials close to that of DA it is difficult to determine dopamine electrochemically, although resolution can be achieved using modified electrodes. Additionally, oxidized dopamine mediates AA oxidation and the electrode surface can be easily fouled by the AA oxidation product. In this work a chemometrics strategy, partial least squares (PLS) regression, has been applied to determine dopamine in the presence of AA and UA without electrode modification. The method is based on the electrooxidation of dopamine at a glassy carbon electrode in pH 7 phosphate buffer. The dopamine calibration curve was linear over the range of 1 -313 µM and the limit of detection was 0.25 µM. The relative standard error (RSE %) was 5.28%. The method has been successfully applied to the measurement of dopamine in human plasma and urine.© Versita Warsaw and Springer-Verlag Berlin Heidelberg.

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Section: Resultssupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

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Voltammetric determination of dopamine in the presence of ascorbic and uric acids using partial least squares regression: determination of dopamine in human urine and plasma

2009

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“…Since the major hurdle in the determination of DA is the coexistence of high levels of ascorbic acid (AA) and uric acid (UA), several methods have been reported for the determination of dopamine in presence of AA and UA. A variety of modified electrodes have been proposed to determine the concentration of dopamine in the presence of excess of ascorbic acid [25][26][27][28][29][30][31][32][33][34][35][36][37]. In the present studies the surface of glassy carbon electrode is modified with nano TiO 2 in the expectation that such modification will improve the current response of the electrode and thus will increase the detection limit of dopamine.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Sensor Based on Nano TiO2 Powder Modified Glassy Carbon Electrode for Determination of Dopamine

Goyal¹,

Kaur²,

Pandey³

2010

TOCBMJ

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Synthesis of TiO 2 nanopowder via a low cost ultrasonic spray pyrolysis technique is reported and the nanopowder is used for the surface modification of glassy carbon electrode. The structural characterization of nanopowder by high temperature XRD clearly shows the phase transformation from anatase to rutile phase on increasing temperature. The morphological structure is characterized by field emission scanning electron microscope and high resolution transmission electron microscope. The modified electrode is used for the determination of dopamine in the presence of excess of ascorbic acid/ uric acid using square-wave voltammetry. The voltammograms obtained during the oxidation studies revealed that nano TiO 2 exhibits better catalytic function towards the oxidation of dopamine and ascorbic acid/uric acid. The overlapping voltammetric response of all the biomolecules at the bare electrode gets resolved into well defined voltammetric peaks with lowered oxidation potential and enhanced oxidation currents. Linear calibration curves for dopamine are obtained over the concentration range 75 nM -2.5 μM in 0.1M phosphate buffer solution at pH 7.2 with a correlation coefficient of 0.9940 and the detection limit (3 ) is estimated to be 13.8 nM.

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“…9 Ruthenium oxide composites were reported as efficient catalysts for non-enzymatic glucose oxidation 10 and for simultaneous determination of ascorbic acid and dopamine. 11 Considerably fewer reports exist on H 2 O 2 detection by using Ru or Ru oxide based electrodes. 12,13 Hydrogen peroxide is an efficient oxidizing agent used in textile industry, cleaning products, food industry and environmental protection 14 and an essential intermediate product of enzymatic reactions.…”

Section: Introductionmentioning

confidence: 99%

Composite Electrodes with Carbon Supported Ru Nanoparticles for H2O2 Detection

Mureşan

Turdean²,

Mula³

et al. 2015

ACSi

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A new carbon paste electrode (CPE) incorporating Ru nanoparticles (RuNP) stabilized on graphite powder was developed for H 2 O 2 amperometric detection. Cyclic voltammetric measurements, performed in phosphate buffer solutions at different potential scan rates and different potential ranges were carried out in order to evaluate the electrochemical behavior of the CPE-RuNP modified electrodes. From cyclic voltammetry, at -0.1 V vs. Ag/AgCl, KCl sat , the relative increase of the H 2 O 2 reduction current varies in the following order: 28.47% (CPE) < 94.81% (CPE-RuNP (2.5:1)) < 118.19% (CPE-RuNP (2.5:3)) < 152.43% (CPE-RuNP (2.5:2), recommending the new electrodes as a promising sensors for hydrogen peroxide detection.

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Simultaneous determination of ascorbic acid and dopamine in the presence of uric acid on ruthenium oxide modified electrode

Cited by 153 publications

References 27 publications

Voltammetric determination of dopamine in the presence of ascorbic and uric acids using partial least squares regression: determination of dopamine in human urine and plasma

Voltammetric determination of dopamine in the presence of ascorbic and uric acids using partial least squares regression: determination of dopamine in human urine and plasma

Voltammetric Sensor Based on Nano TiO2 Powder Modified Glassy Carbon Electrode for Determination of Dopamine

Composite Electrodes with Carbon Supported Ru Nanoparticles for H2O2 Detection

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