Simultaneous determination of arylpropionic acidic non-steroidal anti-inflammatory drugs in pharmaceutical formulations and human plasma by HPLC with UV detection

Sun, Yen; Takaba, Kumiko; Kido, Hiroyuki; Nakashima, Mihoko N.; Nakashima, Kenichiro

doi:10.1016/s0731-7085(02)00549-6

Cited by 73 publications

(49 citation statements)

References 17 publications

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“…The detection limits calculated using a signal-to-noise criterion of 3 were in the 10-35 mg?L 21 range. The results (detection limits) were similar to those of other authors who also analyzed NSAIDs by HPLC [1,38]. Other CE conditions as in Fig.…”

Section: Lvsep In the Methanol Run Buffersupporting

confidence: 89%

Improving sensitivity by large‐volume sample stacking using the electroosmotic flow pump to analyze some nonsteroidal anti‐inflammatory drugs by capillary electrophoresis in water samples

et al. 2003

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Large-volume sample stacking using the electroosmotic flow (EOF) pump (LVSEP) has been used to analyze some nonsteroidal anti-inflammatory drugs (NSAIDs) in water samples. With methanol as the run buffer solvent to suppress the EOF, sensitivity was enhanced by 80-100-fold. The sample for the analysis of real water sample was pretreated by solid-phase extraction (SPE). When the method was based on off-line SPE-LVSEP-CE, sensitivity improved by as much as 1000 times.

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Section: Lvsep In the Methanol Run Buffersupporting

confidence: 89%

Improving sensitivity by large‐volume sample stacking using the electroosmotic flow pump to analyze some nonsteroidal anti‐inflammatory drugs by capillary electrophoresis in water samples

et al. 2003

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“…Naproxen is determined in bulk and pharmaceutical dosage forms by UV spectrophotometric techniques [5,6], TLC [7], HPLC with UV detection methods [8], GC-MS [9], ionselective methods [10], phosphorescence and chemiluminescence methods [11], spectrofluorimetric techniques [12][13][14] and capillary electrophoresis with mass detectors [15][16][17]. Bio-analytical methods for detection of naproxen and its metabolites have also been reported [8]. Most of the aforementioned techniques are time-consuming, involve costly and complicated instruments and therefore are not suitable for routine analysis.…”

Section: Introductionmentioning

confidence: 99%

Conductometric determination of naproxen in bulk and pharmaceutical dosage form

Alhazmi

Bratty

2017

Eur. J. Chem.

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This study aimed at the development of simple and cheap conductometric method that can be used for the determination of naproxen in bulk and dosage forms. During the study, naproxen was titrated with sodium hydroxide (Method A) and potassium hydroxide (Method B) and the end points were determined with conductivity cell. Variables affecting the end point determination were also studied in the range of 1-10 mg/mL of naproxen. The proposed methods were validated by precision and recovery studies. The percentage recoveries ranged from 99.15±0.659 and 101.13±0.543 with % RSD of 0.897 and 0.749 with sodium hydroxide and potassium hydroxide, respectively. The methods were effectively applied for the determination of naproxen in tablet dosage form. The methods proposed in this study can be used as substitute for more composite and classy methods used for the determination of naproxen and are highly reproducible as compared to other reported methods. KEYWORDS

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“…Furthermore, it is also very important to precisely quantify these NSAIDs in pharmaceutical formulations for quality control. 1 Until now, a variety of chromatographic methods have been proposed for the determination of NSAIDs in pharmaceutical formulations and biological fluids, by gas chromatography, 2-4 spectrofluorometry, 5 high performance liquid chromatography [6][7][8][9][10][11][12][13][14][15][16][17] and capillary electrophoresis. 18 Generally, it is impossible that one patient would be prescribed for more than one kind of NSAIDs at the same time; however simultaneous determination of these drugs is useful in pharmaceutical routine analysis and biological samples.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of non-steroidal anti-inflammatory drugs in pharmaceutical formulations and human serum by reversed phase high performance liquid chromatography

Nawaz¹

2012

Quím. Nova

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Recebido em 8/7/11; aceito em 29/11/11; publicado na web em 23/1/12 A rapid and sensitive method using high performance liquid chromatography has been developed and validated for the simultaneous determination of non-steroidal anti-inflammatory drugs (NSAIDs) in pharmaceutical formulations and human serum. Six NSAIDs including: naproxen sodium, diclofenac sodium, meloxicam, flurbiprofen, tiaprofenic and mefenamic acid were analyzed simultaneously in presence of ibuprofen as internal standard on Mediterranea C 18 (5 µm, 250 x 0.46 mm) column. Mobile phase comprised of methanol: acetonitrile: H 2 O (60:20:20, v/v; pH 3.35) and pumped at a flow rate of 1 mL min -1 using 265 nm UV detection. The method was linear over a concentration range of 0.25-50 μg mL -1 (r 2 = 0.9999).

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Simultaneous determination of arylpropionic acidic non-steroidal anti-inflammatory drugs in pharmaceutical formulations and human plasma by HPLC with UV detection

Cited by 73 publications

References 17 publications

Improving sensitivity by large‐volume sample stacking using the electroosmotic flow pump to analyze some nonsteroidal anti‐inflammatory drugs by capillary electrophoresis in water samples

Improving sensitivity by large‐volume sample stacking using the electroosmotic flow pump to analyze some nonsteroidal anti‐inflammatory drugs by capillary electrophoresis in water samples

Conductometric determination of naproxen in bulk and pharmaceutical dosage form

Simultaneous determination of non-steroidal anti-inflammatory drugs in pharmaceutical formulations and human serum by reversed phase high performance liquid chromatography

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