Simultaneous Determination of Amitriptyline Hydrochloride and Propranolol Hydrochloride in Commercial Formulation by Multitudinal UV and Multivariate FT-IR Spectroscopic Methods
Sreenivasa Charan Archakam,
Keerthisikha Palur,
Rajitha Galla
et al.
Abstract:Aim: In the current study, a multivariate FTIR method and two different UV spectrophotometric methods were employed for the simultaneous determination of Amitriptyline Hydrochloride (ATH) and Propranolol Hydrochloride (PPH) in their combined formulation. Materials and Methods: The multivariate FTIR method based on the use of Classical Least Squares (CLS) was developed and executed in the lab solutions software for the simultaneous determination of ATH and PPH. CLS model was performed in the wavenumber range of… Show more
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