Simultaneous determination of 13 sulfonamides at trace levels in soil by modified QuEChERS with HPLC-MS/MS

Abstract

Schematic of the main steps for QuEChERS.

Crystallization and Solvent Evaporation Ionization Mass Spectrometry (CSEI-MS) for Rapid Detection of Drugs in Complex Matrices

“…Due to the contamination of MS parts (capillary, sampling cone, even quadrupole) and ion suppression caused by salts, these samples are unable to be directly analyzed by MS. − Researchers have developed many pretreatment methods to solve these problems and realize the MS analysis of drugs in salt-containing matrices. Solid-phase extraction (SPE) and QuEChER combined with MS are often used to detect antibiotics and sulfonamides residing in seawater or soil. − However, these methods are cumbersome and time-consuming, and some trace analytes may be degraded through pretreatments.…”