Simultaneous Detection of Regular Patterns in Ancient Manuscripts Using GAN-Based Deep Unsupervised Segmentation

Tamrin, Milad Omrani; Cheriet, Mohamed

doi:10.1007/978-3-030-68787-8_20

Cited by 1 publication

(1 citation statement)

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“…Image segmentation is a process in which parts of an image that correspond to distinct objects are identified (for example, the identification of a specific marker in cellular images). [ 120,121 ] Therefore, we evaluated the intensity sum values for the green channel in each group by an object‐based 3D‐surface segmentation method using Imaris (Figure S7, Supporting Information). Macrophages cocultured with IL‐10 loaded microgels had exceptionally bright and ≈threefold higher CD163 intensity than the IL‐10 free groups.…”

Section: Resultsmentioning

confidence: 99%

Immunomodulatory Microgels Support Proregenerative Macrophage Activation and Attenuate Fibroblast Collagen Synthesis

Mohammadi

Ravanbakhsh

Taheri

et al. 2022

Adv Healthcare Materials

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Scars composed of fibrous connective tissues are natural consequences of injury upon incisional wound healing in soft tissues. Hydrogels that feature a sustained presentation of immunomodulatory cytokines are known to modulate wound healing. However, existing immunomodulatory hydrogels lack interconnected micropores to promote cell ingrowth. Other limitations include invasive delivery procedures and harsh synthesis conditions that are incompatible with drug molecules. Here, hybrid nanocomposite microgels containing interleukin‐10 (IL‐10) are reported to modulate tissue macrophage phenotype during wound healing. The intercalation of laponite nanoparticles in the polymer network yields microgels with tissue‐mimetic elasticity (Young's modulus in the range of 2–6 kPa) and allows the sustained release of IL‐10 to promote the differentiation of macrophages toward proregenerative phenotypes. The porous interstitial spaces between microgels promote fibroblast proliferation and fast trafficking (an average speed of ≈14.4 µm h−1). The incorporation of hyaluronic acid further enhances macrophage infiltration. The coculture of macrophages and fibroblasts treated with transforming growth factor‐beta 1 resulted in a twofold reduction in collagen‐I production for microgels releasing IL‐10 compared to the IL‐10 free group. The new microgels show potential toward regenerative healing by harnessing the antifibrotic behavior of host macrophages.

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Section: Resultsmentioning

confidence: 99%