Abstract:We propose an analytical framework to build a microfluidic microsphere-trap array device that enables simultaneous, efficient, and accurate screening of multiple biological targets in a single microfluidic channel. By optimizing the traps' geometric parameters, the trap arrays in the channel of the device can immobilize microspheres of different sizes at different regions, obeying hydrodynamically engineered trapping mechanism. Different biomolecules can be captured by the ligands on the surfaces of microspher… Show more
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