Simultaneous detection of multiple bioactive pollutants using a multiparametric biochip for water quality monitoring

Guijarro, Christian; Fuchs, Karen; Bohrn, Ulrich; Stütz, Evamaria; Wölfl, Stefan

doi:10.1016/j.bios.2015.04.092

Cited by 8 publications

(9 citation statements)

References 43 publications

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“…[13] Besides,mitochondrial respiration was immediately inhibited by 1,asevidenced by the instant decrease of the respiration rate monitored with aB ionas 2500 real-time biosensor chip system, which can be applied to analyze the metabolism and morphological changes of cells ( Figure 5). [14] This verifies that the dysfunction of mitochondria appeared earlier than the increase of ROS. Moreover,avery sharp decrease of the respiration rate was observed at the concentration of 12 mm, accompanied by as ignificant decrease of glycolysis and induction of cell death indicated by the predominant decline of acidification and drastic reduction in impedance,r espectively.Ashort and slight increase in cell impedance might be ascribed to the generation of stress fibers.…”

Section: Methodsmentioning

confidence: 56%

A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells

et al. 2020

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A novel alkynyl phosphane gold(I) complex (trimethylphosphane)(3‐(1,3‐dimethylxanthine‐7‐yl)prop‐1‐yn‐1‐yl)gold(I) 1 displayed mutiple biological activites including selective proliferation inhibitory, anti‐metastatic, and anti‐angiogenic effects. The complex also induced effects related to aneuploidy in HCT‐116 colon carcinoma cells, which might be mainly ascribed to the dysfunction of mitochondrial bioenergetics and downregulation of glycolysis. Induction of aneuploidy beyond a critical level can provide an effective strategy to target cancer, in particular colorectal tumours with a low tolerance of aneuploidy, and could be of relevance for 1 and other metallodrugs.

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Section: Methodsmentioning

confidence: 56%

A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells

et al. 2020

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“…For instance, Zhuiykov et al [ 5 ] have reported an integrated multi-sensor based on screen-printed RuO 2 thick films to detect the main parameters of water, such as pH, temperature, DO, conductivity, and turbidity. Guijarro et al [ 6 ] have presented a multi-parametric biochip fabricated by MEMS technique, which was capable of simultaneously detecting bioactive pollutants in water. In addition, Wang et al [ 7 ] proposed a microelectrode for simultaneous detection of copper and lead heavy metallic ions.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a Miniature Multi-Parameter Sensor Chip for Water Quality Assessment

Zhou

Bian

Tong

et al. 2017

Sensors

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Water contamination is a main inducement of human diseases. It is an important step to monitor the water quality in the water distribution system. Due to the features of large size, high cost, and complicated structure of traditional water determination sensors and devices, it is difficult to realize real-time water monitoring on a large scale. In this paper, we present a multi-parameter sensor chip, which is miniature, low-cost, and robust, to detect the pH, conductivity, and temperature of water simultaneously. The sensor chip was fabricated using micro-electro-mechanical system (MEMS) techniques. Iridium oxide film was electrodeposited as the pH-sensing material. The atomic ratio of Ir(III) to Ir(IV) is about 1.38 according to the X-ray photoelectron spectroscopy (XPS) analysis. The pH sensing electrode showed super-Nernstian response (−67.60 mV/pH) and good linearity (R2 = 0.9997), in the range of pH 2.22 to pH 11.81. KCl-agar and epoxy were used as the electrolyte layer and liquid junction for the solid-state reference electrode, respectively, and its potential stability in deionized water was 56 h. The conductivity cell exhibited a linear determination range from 21.43 sans-serifμnormalS/cm to 1.99 mS/cm, and the electrode constant was 1.566 cm−1. Sensitivity of the temperature sensor was 5.46 sans-serifΩ/°normalC. The results indicate that the developed sensor chip has potential application in water quality measurements.

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“…Aptamers, for example, are single-stranded RNA or DNA oligonucleotides, whose tertiary structure selectively binds their target molecules [ 26 ]. Another option is whole-cell-based sensors, which were also already applied to real wastewater samples [ 27 , 28 ]. In this case, mammalian cells were used for detecting harmful and toxic compounds, because their closeness physiology is close to that of humans.…”

Section: Biomimetic Approaches For Sensing Water Qualitymentioning

confidence: 99%

“…It responded to different contaminants and was indeed suitable for monitoring unknown, harmful compounds in water. Similarly, the group of C. Guijarro applied rat liver cells in a whole-cell-based sensor system to monitor environmental contaminants, including an insecticide and a flame retardant, in water samples using the same analyzing system [ 28 ].…”

Section: Biomimetic Approaches For Sensing Water Qualitymentioning

confidence: 99%

Real-Time Water Quality Monitoring with Chemical Sensors

Yaroshenko

Kirsanov

Marjanovic

et al. 2020

Sensors

114

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Water quality is one of the most critical indicators of environmental pollution and it affects all of us. Water contamination can be accidental or intentional and the consequences are drastic unless the appropriate measures are adopted on the spot. This review provides a critical assessment of the applicability of various technologies for real-time water quality monitoring, focusing on those that have been reportedly tested in real-life scenarios. Specifically, the performance of sensors based on molecularly imprinted polymers is evaluated in detail, also giving insights into their principle of operation, stability in real on-site applications and mass production options. Such characteristics as sensing range and limit of detection are given for the most promising systems, that were verified outside of laboratory conditions. Then, novel trends of using microwave spectroscopy and chemical materials integration for achieving a higher sensitivity to and selectivity of pollutants in water are described.

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Simultaneous detection of multiple bioactive pollutants using a multiparametric biochip for water quality monitoring

Cited by 8 publications

References 43 publications

A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells

A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells

Fabrication of a Miniature Multi-Parameter Sensor Chip for Water Quality Assessment

Real-Time Water Quality Monitoring with Chemical Sensors

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