Simultaneous delivery of therapeutic antagomirs with paclitaxel for the management of metastatic tumors by a pH-responsive anti-microbial peptide-mediated liposomal delivery system

Zhang, Qianyu; Ran, Rui; Zhang, Li; Liu, Yayuan; Mei, Ling; Zhang, Zhirong; Gao, Huile; He, Qin

doi:10.1016/j.jconrel.2014.11.010

Cited by 68 publications

(45 citation statements)

References 60 publications

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“…Enhanced cellular uptake, cytotoxicity and suppressed cancer growth were obtained. Zhang et al 339 showed efficacious accumulation of liposomal nanocarriers in tumors followed by their lysosomal escape (Fig. 18c).…”

Section: Different Stimuli-responsive Mnpsmentioning

confidence: 93%

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Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

et al. 2016

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New achievements in the realm of nanoscience and innovative techniques of nanomedicine have moved micro/nanoparticles (MNPs) to the point of becoming actually useful for practical applications in the near future. Various differences between the extracellular and intracellular environments of cancerous and normal cells and the particular characteristics of tumors such as physicochemical properties, neovasculature, elasticity, surface electrical charge, and pH have motivated the design and fabrication of inventive “smart” MNPs for stimulus-responsive controlled drug release. These novel MNPs can be tailored to be responsive to pH variations, redox potential, enzymatic activation, thermal gradients, magnetic fields, light, and ultrasound (US), or can even be responsive to dual or multi-combinations of different stimuli. This unparalleled capability has increased their importance as site-specific controlled drug delivery systems (DDSs) and has encouraged their rapid development in recent years. An in-depth understanding of the underlying mechanisms of these DDS approaches is expected to further contribute to this groundbreaking field of nanomedicine. Smart nanocarriers in the form of MNPs that can be triggered by internal or external stimulus are summarized and discussed in the present review, including pH-sensitive peptides and polymers, redox-responsive micelles and nanogels, thermo- or magnetic-responsive nanoparticles (NPs), mechanical- or electrical-responsive MNPs, light or ultrasound-sensitive particles, and multi-responsive MNPs including dual stimuli-sensitive nanosheets of graphene. This review highlights the recent advances of smart MNPs categorized according to their activation stimulus (physical, chemical, or biological) and looks forward to future pharmaceutical applications.

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Section: Different Stimuli-responsive Mnpsmentioning

confidence: 93%

Section: Figmentioning

confidence: 99%

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

et al. 2016

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“…[47] A number of NP formulations loaded PTX are being developed in preclinical studies for improved efficacy such as liposomes, lipid and polymeric NPs, and nanocrystals. [48–50] A liposome drug delivery system was developed to treat breast cancer by co-delivery of antagomir-10b and PTX. The system takes advantages of anticancer properties of PTX and anti-metastasis properties of antagomir-10b.…”

Section: Treatment Of Metastatic Breast Cancer Using Nanoparticlesmentioning

confidence: 99%

Nanoparticles for imaging and treatment of metastatic breast cancer

Wang

Zhang

2016

Expert Opinion on Drug Delivery

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Introduction Metastatic breast cancer is one of the most devastating cancers that have no cure. Many therapeutic and diagnostic strategies have been extensively studied in the past decade. Among these strategies, cancer nanotechnology has emerged as a promising strategy in preclinical studies by enabling early identification of primary tumors and metastases, and by effective killing of cancer cells. Areas covered This review covers the recent progress made in targeting and imaging of metastatic breast cancer with nanoparticles, and treatment using nanoparticle-enabled chemo-, gene, photothermal- and radio-therapies. This review also discusses recent developments of nanoparticle-enabled stem cell therapy and immunotherapy. Expert opinion Nanotechnology is expected to play important roles in modern therapy for cancers, including metastatic breast cancer. Nanoparticles are able to target and visualize metastasis in various organs, and deliver therapeutic agents. Through targeting cancer stem cells, nanoparticles are able to treat resistant tumors with minimal toxicity to healthy tissues/organs. Nanoparticles are also able to activate immune cells to eliminate tumors. Owing to their multifunctional, controllable and trackable features, nanotechnology-based imaging and therapy could be a highly potent approach for future cancer research and treatment.

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“…Recently, combination of small-molecule anticancer drugs with therapeutic nucleic acids, such as siRNA and miRNA, emerged as a promising strategy in cancer treatment [2–7]. Due to the heterogeneity of cancer and the involvement of multiple gene mutations during tumorigenesis and tumor progression, such combination therapies provide potentially great advantages in targeting multiple cancer-associated pathways and overcoming adaptive drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy

Xie

Murray-Stewart

Wang

et al. 2017

Journal of Controlled Release

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Combination of anticancer drugs with therapeutic miRNA has emerged as a promising anticancer strategy. However, the promise is hampered by a lack of desirable delivery systems. We report on the development of self-immolative nanoparticles capable of simultaneously delivering miR-34a mimic and targeting dysregulated polyamine metabolism in cancer. The nanoparticles were prepared from a biodegradable polycationic prodrug, named DSS-BEN, which was synthesized from a polyamine analog N1,N11-bisethylnorspermine (BENSpm). The nanoparticles were selectively disassembled in the cytoplasm where they released miRNA. Glutathione (GSH)-induced degradation of self-immolative linkers released BENSpm from the DSS-BEN polymers. MiR-34a mimic was effectively delivered to cancer cells as evidenced by upregulation of intracellular miR-34a and downregulation of Bcl-2 as one of the downstream targets of miR-34a. Intracellular BENSpm generated from the degraded nanoparticles induced the expression of rate-limiting enzymes in polyamine catabolism (SMOX, SSAT) and depleted cellular natural polyamines. Simultaneous regulation of polyamine metabolism and miR-34a expression by DSS-BEN/miR-34a not only enhanced cancer cell killing in cultured human colon cancer cells, but also improved antitumor activity in vivo. The reported findings validate the self-immolative nanoparticles as delivery vectors of therapeutic miRNA capable of simultaneously targeting dysregulated polyamine metabolism in cancer, thereby providing an elegant and efficient approach to combination nanomedicines.

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Simultaneous delivery of therapeutic antagomirs with paclitaxel for the management of metastatic tumors by a pH-responsive anti-microbial peptide-mediated liposomal delivery system

Cited by 68 publications

References 60 publications

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

Nanoparticles for imaging and treatment of metastatic breast cancer

Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy

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