Simultaneous comparison of pre‐ and post‐microanastomotic hemodynamic profiles using a Tandem Doppler Probe

In a previous study, we have demonstrated that turbulences in arteries less than 1.5 mm in diameter perfused ex vivo by an oscillated flow can be determined using nonlinear mathematical models. The hypothesis tested here was that nonlinear analyses enable the in vivo detection of turbulences in blood flow in vessels with dimensions affected by microsurgery. Twenty Wistar male rats were studied. After an intraperitoneal anesthesia (50 mg/kg sodium pentobarbital), each right carotid artery was dissected and a transit time flowmeter was used to measure blood flow. Arteries were studied in control conditions and graded stenoses, which were performed by a collar system and progressively increased from 0 to 95%. For each flow signal, time delay, false-nearest neighbors, correlation dimension and the largest Lyapunov exponent were computed to characterize the level of turbulence. The level of turbulence was highly correlated with the degree of stenosis induced (p < 0.001). The correlation dimensions of all the flow signals varied between 3 and 5, thus implying that more than three independent noninteger control variables were necessary to account for the complexity of rat carotid artery dynamics. Turbulence flow significantly increased in arteries with 40–95% stenosis. Nonlinear analysis may be useful to determine the turbulence level of an in vivo flow in arteries less than 1.5 mm in diameter and might be clinical useful for turbulence detection after microsurgery.

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“…The flow was measured using a transit time flowmeter (Transonic Systems, Ithaca, N.Y., USA) [25, 26, 27, 28]. Flow probes (No.…”

Section: Methodsmentioning

confidence: 99%

Detection of Hemodynamic Turbulence in Experimental Stenosis: An in vivo Study in the Rat Carotid Artery

May

Arrouvel²,

Revol³

et al. 2002

J Vasc Res

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New four-stitch sleeve anastomosis: An experimental study in rats with reports of clinical use

et al. 1996

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A new technique for microvascular four-stitch sleeve anastomosis of arteries is described. Modifications from previously described techniques include absence of suture material within the arterial lumen, and a decreased proximal to distal artery overlap. In 40 rat arterial anastomoses, 100% patency without evidence of stenosis or early aneurysm formation was seen up to 6 weeks postoperatively by in vivo observation, arteriography and Doppler flow study. This new anastomosis was also successful in repairing two clinical cases of complete radial artery transection as evident from physical examination and doppler flow study. We believe that this new four-stitch sleeve anastomosis is faster and easier to perform and has patency and flow characteristics similar to those of the conventional end-to-end anastomosis.

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A new technique for microvascular sleeve anastomosis

et al. 1991

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This study describes our experience using an improved technique for microsurgical sleeve anastomosis of arteries. Modifications of previously described techniques include utilization of a sidecut and placement of the two stitches within separate vertical planes. In 40 arteries, we attained a patency rate of 97.5%. Histology, in vivo observation, and flow study using high-frequency pulsed ultrasound Doppler at 2 hr to 8 weeks demonstrate that the sidecut sleeve anastomosis shows patency and flow characteristics similar to those of standard end-to-end anastomosis, but with a dramatic decrease in operative time.

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Simultaneous comparison of pre‐ and post‐microanastomotic hemodynamic profiles using a Tandem Doppler Probe

Cited by 6 publications

References 28 publications

Detection of Hemodynamic Turbulence in Experimental Stenosis: An in vivo Study in the Rat Carotid Artery

Detection of Hemodynamic Turbulence in Experimental Stenosis: An in vivo Study in the Rat Carotid Artery

New four-stitch sleeve anastomosis: An experimental study in rats with reports of clinical use

A new technique for microvascular sleeve anastomosis

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