Simultaneous colorimetric determination of morphine and ibuprofen based on the aggregation of gold nanoparticles using partial least square

Bahram, Morteza; Madrakian, Tayyebeh; Alizadeh, Sakineh

doi:10.1016/j.jpha.2017.03.001

Cited by 39 publications

(15 citation statements)

References 37 publications

(35 reference statements)

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“…IBU alone or in combination with other drugs was determined using a variety of analytical techniques including gas chromatography (GC) [4,5], highperformance liquid chromatography (HPLC) [5][6][7], spectrophotometry [8,9], kinetic spectrophotometry [10], spectrofluorometry [11], colorimetry [12], and infrared (IR) spectroscopy [13].…”

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confidence: 99%

A new gas chromatographic method development and validation for the simultaneous determination of ibuprofen and caffeine in bulk and pharmaceutical dosage form

Zambakjian

Sakur

2020

Futur J Pharm Sci

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Background Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties. Caffeine is one of the most common adjuvant analgesic drugs which is combined with ibuprofen in commercially available formulations. Combining analgesics offers the possibility of increasing effectiveness without increasing dose and therefore risk. Prescribing ibuprofen and caffeine together is common in clinical practice. This is the first work reporting a new and validated gas chromatographic method for the simultaneous determination of ibuprofen and caffeine in bulk and pharmaceutical dosage form. The separation was performed on a TRB-17 column (30.00 m in length, 0.25-mm ID, and 0.25-μm df). Detection was carried out using a flame ionization detector (FID). Methyl paraben was used as an internal standard. The injection volume was 1 μL with 1:50 split ratio using nitrogen as a carrier gas at a flow rate of 1 mL/min. The oven temperature was programmed at 150 °C for 0.5 min, with a rise of 10 °C/min up to 250 °C. The injector temperature was 280 °C, and the detector temperature was 300 °C. The validation of the method including linearity, range, detection limit (DL), quantitation limit (QL), accuracy, precision, specificity, system suitability, and robustness was carried out utilizing International Conference on Harmonization (ICH) guidelines. Results The retention times of methyl paraben, ibuprofen, and caffeine were 1.687, 2.594, and 4.031 min, respectively. The method was linear in the range of 1000–7000 μg/mL for ibuprofen and 162.5–1137.5 μg/mL for caffeine with a correlation coefficient of 0.9999 for both drugs. The DL was found to be 131.68 μg/mL and 15.74 μg/mL for ibuprofen and caffeine, respectively, whereas QL was found to be 399.02 μg/mL for ibuprofen and 47.68 μg/mL for caffeine. The accuracy of the method was validated by mean percentage recovery, which was found to be in the acceptable range. The precision study results of the new method were less than the maximum allowable limit percentage of relative standard deviation %RSD ≤ 2.0. The specificity was evaluated by the standard edition method, and the results of the recovery data showed that excipients do not affect the accuracy of the proposed method. The results of system suitability and robustness tests were also within the acceptable limits. Conclusion The first reported method for simultaneous determination of ibuprofen and caffeine by gas chromatography in bulk and combined dosage form was carried out in this work. The developed method gave a good separation of the drugs and internal standard. The analytical performance of the method was statistically validated as per ICH guidelines, and satisfactory results were obtained. The proposed method can be easily adopted for the routine analysis of ibuprofen and caffeine.

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confidence: 99%

A new gas chromatographic method development and validation for the simultaneous determination of ibuprofen and caffeine in bulk and pharmaceutical dosage form

Zambakjian

Sakur

2020

Futur J Pharm Sci

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“…Ferns method [31]. Briefly, 100 ml of 1 mmol (3100-3500 cm -1 and 1400-1700 cm -1 ), C=C (1500-1700 cm -1 ) and C=N (1600-1700 cm -1 ) is available which indicates that PHCA had interaction with AuNPs.…”

Section: Synthesis Of Aunpsmentioning

confidence: 99%

“…the solution of prepared citratecapped AuNPs (Figure 1) was wine red, and has a characteristic localized surface plasmon resonance (LSPR) absorption band of AuNPs in 520 nm (λmax) with narrow peak.In solution, monodisperse AuNPs appeared red and exhibited a relatively narrow surface plasmon absorption band around 520 nm in the UV-Vis spectrum. In contrast, in the surface plasmon resonance to higher wavelength in 660nm[31,32]. Figure2 (A-B) shows the IR spectra of synthesized Au Nano particles, before and after aggregation.…”

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confidence: 97%

Selective and Sensitive Simultaneous Determination of Mercury and Cadmium based on the Aggregation of PHCA Modified- AuNPs in West Azerbaijan Regional Waters

2019

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The present study aims to present a new convenient sensor for heavy metals, based on aggregation of citrate-capped-N, N' biphenyl hydrazine 1, 2 dicarbothioamide (PHCA) -modified-(AuNPs). This paper reports a procedure for sensitive and selective spectrophotometric methods for simultaneous determination of mercury (Hg2 2+ ) and cadmium (Cd 2+ ). For this aim multivariate data including kinetic spectra of AuNPs were collected during aggregation process. The characterization of AuNPs was performed by transmission electron microscopy (TEM) and Infra-Red (IR) spectroscopy. Partial least square (PLS) regression as an efficient multivariate calibration method was employed to make a connection between the surface plasmon resonance (SPR) spectra of the generated AuNPs. The number of PLS latent variables was optimized by leave-one-out cross-validation utilizing prediction residual error sum of square (PRESS). The linear range was in the range of 3.33 × 10 -5 -3.33 × 10 -6 mol L -1 and 2.0 × 10 -5 -1.0 × 10 -6 mol L -1 , the detection limit was 1.21×10 -7 and 0.5 ×10 -7 mol L -1 (n=5) for Hg2 2+ and Cd 2+ , respectively. This method used successfully for simultaneous determination of Hg2 2+ and Cd 2+ in West Azerbaijan regional waters namely Zarineh / Simineh rivers and Urmia lake. Cadmium Mercury Gold Nanoparticles Simultaneous Determination Multivariate Analysis

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“…The traditional analytical methods for quantifying active pharmaceutical ingredients (API) include chromatographic [ 1 , 2 , 3 , 4 ] and optical techniques (UV–Vis) [ 5 , 6 , 7 ]. These methods have high reproducibility and low detection limits, although they involve destroying the samples or transporting them to the laboratory for further analysis.…”

Section: Introductionmentioning

confidence: 99%

API Content and Blend Uniformity Using Quantum Cascade Laser Spectroscopy Coupled with Multivariate Analysis

et al. 2021

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The process analytical technology (PAT) initiative proposed by the US Food and Drug Administration (FDA) suggests innovative methods to better understand pharmaceutical processes. The development of analytical methods that quantify active pharmaceutical ingredients (APIs) in powders and tablets is fundamental to monitoring and controlling a drug product’s quality. Analytical methods based on vibrational spectroscopy do not require sample preparation and can be implemented during in-line manufacturing to maintain quality at each stage of operations. In this study, a mid-infrared (MIR) quantum cascade laser (QCL) spectroscopy-based protocol was performed to quantify ibuprofen in formulations of powder blends and tablets. Fourteen blends were prepared with varying concentrations from 0.0% to 21.0% (w/w) API. MIR laser spectra were collected in the spectral range of 990 to 1600 cm−1. Partial least squares (PLS) models were developed to correlate the intensities of vibrational signals with API concentrations in powder blends and tablets. PLS models were evaluated based on the following figures of merit: correlation coefficient (R2), root mean square error of calibration, root mean square error of prediction, root mean square error of cross-validation, and relative standard error of prediction. QCL assisted by multivariate analysis was demonstrated to be accurate and robust for analysis of the content and blend uniformity of pharmaceutical compounds.

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Simultaneous colorimetric determination of morphine and ibuprofen based on the aggregation of gold nanoparticles using partial least square

Cited by 39 publications

References 37 publications

A new gas chromatographic method development and validation for the simultaneous determination of ibuprofen and caffeine in bulk and pharmaceutical dosage form

A new gas chromatographic method development and validation for the simultaneous determination of ibuprofen and caffeine in bulk and pharmaceutical dosage form

Selective and Sensitive Simultaneous Determination of Mercury and Cadmium based on the Aggregation of PHCA Modified- AuNPs in West Azerbaijan Regional Waters

API Content and Blend Uniformity Using Quantum Cascade Laser Spectroscopy Coupled with Multivariate Analysis

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