Simultaneous bilateral acute angle closure glaucoma following venlafaxine treatment

Ezra, Daniel G.; Storoni, Mithu; Whitefield, Laurence

doi:10.1038/sj.eye.6701815

Cited by 30 publications

(15 citation statements)

References 9 publications

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“…9,22 Additional case reports have also implicated non-SSRI antidepressant drugs including venlafaxine 23,24 and trazodone 25 as potentially contributing to AACG. Evidence from case reports has suggested that SSRI antidepressant drugs including fluoxetine, paroxetine, fluvoxamine, citalopram, and escitalopram are associated with the development of AACG.…”

Section: Discussionmentioning

confidence: 99%

Short-Term Exposure to Antidepressant Drugs and Risk of Acute Angle-Closure Glaucoma Among Older Adults

Seitz¹,

Campbell²,

Bell³

et al. 2012

Journal of Clinical Psychopharmacology

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Acute angle-closure glaucoma (AACG) is an ocular emergency that may be precipitated by certain types of medications. Antidepressant drugs can affect a number of neurotransmitters, which are involved in the regulation of the iris, which may precipitate AACG. We used a case-crossover study design to investigate the association between recent exposure to antidepressant drugs and AACG. We identified patients with AACG among adults aged 66 years or older between 1998 and 2010 in Ontario using linked population-based administrative databases. We identified intermittent users of antidepressant medications through prescription drug claims in the year preceding AACG. We determined antidepressant exposure in the period immediately before AACG and compared it with antidepressant exposure in 2 earlier control periods. We used conditional logistic regression to determine the odds ratio for antidepressant exposure in the hazard period compared with the control periods. A total of 6470 patients with AACG occurred during the study period. The mean age of the patients was 74.3 years, and 66% were female. Overall, 5.6% of individuals were intermittent users of antidepressant drugs in the year preceding AACG. The odds ratio for any antidepressant exposure in the period immediately preceding AACG was 1.62 (95% confidence interval, 1.16-2.26). An increased risk of AACG was also observed in several subgroups. We conclude that recent exposure to antidepressant drugs is associated with an increased risk of AACG. Clinicians should remain vigilant for the development of this uncommon but potentially serious adverse event after initiating antidepressant therapy.

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Section: Discussionmentioning

confidence: 99%

Short-Term Exposure to Antidepressant Drugs and Risk of Acute Angle-Closure Glaucoma Among Older Adults

Seitz¹,

Campbell²,

Bell³

et al. 2012

Journal of Clinical Psychopharmacology

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“…A subsequent review indicates that the use of different SSRIs may increase intraocular pressure and lead to the emergence of angle-closure glaucoma [198], which case reports have also indicated may be caused by venlafaxine [199,200]. In addition, a nested case-control study found that that the risk of angle-closure glaucoma was doubled among patients younger than 50 years taking bupropion [201].…”

Section: Ophthalmic Effectsmentioning

confidence: 99%

The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature

Carvalho

Sharma²,

Brunoni³

et al. 2016

Psychother Psychosom

486

357

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Newer generation antidepressant drugs (ADs) are widely used as the first line of treatment for major depressive disorders and are considered to be safer than tricyclic agents. In this critical review, we evaluated the literature on adverse events, tolerability and safety of selective serotonin reuptake inhibitors, serotonin noradrenaline reuptake inhibitors, bupropion, mirtazapine, trazodone, agomelatine, vilazodone, levomilnacipran and vortioxetine. Several side effects are transient and may disappear after a few weeks following treatment initiation, but potentially serious adverse events may persist or ensue later. They encompass gastrointestinal symptoms (nausea, diarrhea, gastric bleeding, dyspepsia), hepatotoxicity, weight gain and metabolic abnormalities, cardiovascular disturbances (heart rate, QT interval prolongation, hypertension, orthostatic hypotension), genitourinary symptoms (urinary retention, incontinence), sexual dysfunction, hyponatremia, osteoporosis and risk of fractures, bleeding, central nervous system disturbances (lowering of seizure threshold, extrapyramidal side effects, cognitive disturbances), sweating, sleep disturbances, affective disturbances (apathy, switches, paradoxical effects), ophthalmic manifestations (glaucoma, cataract) and hyperprolactinemia. At times, such adverse events may persist after drug discontinuation, yielding iatrogenic comorbidity. Other areas of concern involve suicidality, safety in overdose, discontinuation syndromes, risks during pregnancy and breast feeding, as well as risk of malignancies. Thus, the rational selection of ADs should consider the potential benefits and risks, likelihood of responsiveness to the treatment option and vulnerability to adverse events. The findings of this review should alert the physician to carefully review the appropriateness of AD prescription on an individual basis and to consider alternative treatments if available.

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“…1-3 약물에 의해 양안에 모두 급성 폐쇄각발작 이 발생한 경우는 이전에 topiramate 4 , hydrochlorothiazide 5,6 , selective serotonin reuptake inhibitors 7,8 , sildenafil citrate …”

Section: 약물에 의한 급성 폐쇄각발작의 발생기전은 상대적 동공 차단 혹은 맥락막 삼출의 기전으로 인해 발생하는 것으로unclassified

A Case of Bilateral Acute Angle Closure Attack Induced by Common Cold Medication

Hong

Lee

Song

2016

J Korean Ophthalmol Soc

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Purpose:The authors report a case of bilateral simultaneous acute angle closure attack following administration of an over-the-counter common cold medication (ingredients: chlorpheniramine maleate, phenylephrine hydrochloride, and belladonna alkaloid). Case summary: A 67-year-old man visited the emergency room with a sudden onset of bilateral blurred vision and ocular pain accompanied by headache, nausea, and vomiting. He had taken an over-the-counter common cold medication three times per day for three days before the visit. His visual acuity was 0.3 and 0.7 and intraocular pressure (IOP) was 50 mm Hg and 40 mm Hg in right and left eye, respectively. The refraction in manifest refractive test was +0.75 D sph = -0.75 D cyl × 100 in right eye and +1.25 D sph = -1.25 D cyl × 80 in left eye. The anterior chamber depth was three times the corneal thickness in center and less than 1/4 of the corneal thickness in periphery in both eyes on van Herick method. The angles of both eyes were closed on gonioscopy. He was treated with ocular hypotensive medication and miotics followed by withdrawal of common cold medications. After 10 days, bilateral neodymium-doped yttrium aluminium garnet (Nd:YAG) laser peripheral iridotomies were done. During four months of follow-up, there was no recurrence of angle closure attack, and normal IOP was maintained without glaucoma medications. Conclusions: Common cold medications which are easily accessible can induce acute angle closure attack in those who are predisposed to develop angle closure attacks, hence attention must be taken in those people when taking common cold medications. J Korean Ophthalmol Soc 2016;57(2):334-340

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Simultaneous bilateral acute angle closure glaucoma following venlafaxine treatment

Cited by 30 publications

References 9 publications

Short-Term Exposure to Antidepressant Drugs and Risk of Acute Angle-Closure Glaucoma Among Older Adults

Short-Term Exposure to Antidepressant Drugs and Risk of Acute Angle-Closure Glaucoma Among Older Adults

The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature

A Case of Bilateral Acute Angle Closure Attack Induced by Common Cold Medication

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