Simultaneous assessment of regional distributions of atrophy across the neuraxis in MS patients

Freund, Patrick; Papinutto, Nico; Bischof, Antje; Azzarito, Michela; Kirkish, Gina; Ashburner, John; Thompson, Alan J.; Henry, Roland G.

doi:10.1016/j.nicl.2022.102985

Cited by 9 publications

(10 citation statements)

References 44 publications

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“…Recent studies have compared these 2 acquisitions in voxel-based studies through a Statistical Parametric Mapping (http://www.fil.ion.ucl.ac.uk/spm/ software/spm12) approach. 5,6 The agreement in the thickness measured in most of the cortical regions was very high, suggesting that the values obtained from brain-T1 were very close to the ones obtained with cns-T1. This result was not the case for a few regions along the midline in the frontal and occipital lobes.…”

Section: Discussionsupporting

confidence: 59%

“…3 Regarding lesion topography and atrophy quantification, both the brain and spinal cord are assessed separately, requiring the acquisition of 2 images, 4 although recent studies have highlighted the relevance of acquiring simultaneous brain and spinal cord MR imaging. 5,6 Several attempts have been made to assess the estimation of spinal cord area (SCA) from brain acquisitions, instead of from spinal cord MR imaging, showing that the estimated SCA values differ. 7,8 Despite SCAs differing, estimation from brain acquisitions is quite common and has been proposed as an alternative in cases in which spinal cord MR imaging has not been acquired, which is a common situation due to the limited availability of the MR imaging scanner.…”

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confidence: 99%

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Assessing the Equivalence of Brain-Derived Measures from Two 3D T1-Weighted Acquisitions: One Covering the Brain and One Covering the Brain and Spinal Cord

Pareto¹,

Corral²,

García-Vidal³

et al. 2023

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:In MS, it is common to acquire brain and spinal cord MR imaging sequences separately to assess the extent of the disease. The goal of this study was to see how replacing the traditional brain T1-weighted images (brain-T1) with an acquisition that included both the brain and the cervical spinal cord (cns-T1) affected brain-and spinal cord-derived measures.MATERIALS AND METHODS: Thirty-six healthy controls (HC) and 42 patients with MS were included. Of those, 18 HC and 35 patients with MS had baseline and follow-up at 1 year acquired on a 3T magnet. Two 3D T1-weighted images (brain-T1 and cns-T1) were acquired at each time point. Regional cortical thickness and volumes were determined with FastSurfer, and the percentage brain volume change per year was obtained with SIENA. The spinal cord area was estimated with the Spinal Cord Toolbox. Intraclass correlation coefficients (ICC) were calculated to check for consistency of measures obtained from brain-T1 and cns-T1.RESULTS: Cortical thickness measures showed an ICC .0.75 in 94% of regions in healthy controls and 80% in patients with MS. Estimated regional volumes had an ICC .0.88, and the percentage brain volume change had an ICC .0.79 for both groups. The spinal cord area measures had an ICC of 0.68 in healthy controls and 0.92 in patients with MS.CONCLUSIONS: Brain measurements obtained from 3D cns-T1 are highly equivalent to those obtained from a brain-T1, suggesting that it could be feasible to replace the brain-T1 with cns-T1.ABBREVIATIONS: cns ¼ central nervous system; EDSS ¼ Expanded Disability Status Scale; HC ¼ healthy control; ICC ¼ intraclass correlation coefficient; PBVC ¼ percentage brain volume change; SCA ¼ spinal cord area; SSIM ¼ structural similarity index

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Section: Discussionsupporting

confidence: 59%

mentioning

confidence: 99%

Assessing the Equivalence of Brain-Derived Measures from Two 3D T1-Weighted Acquisitions: One Covering the Brain and One Covering the Brain and Spinal Cord

Pareto¹,

Corral²,

García-Vidal³

et al. 2023

AJNR Am J Neuroradiol

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“…different horns) would, in theory, be made possible with higher spatial resolution acquisitions, scans with improved GM:WM contrast, and using standard space atlases. Voxel-wise mapping methods have already been used to assess whole-cord atrophy ( Freund et al, 2022 , Valsasina et al, 2013 ). Another candidate is tensor-based morphometry, a method based on extracting the Jacobian matrix of the warp fields to a template space, which has been used to look at cord and GM regional volumes between younger and older healthy adults ( Taso et al, 2015 ).…”

Section: Avenues For Future Researchmentioning

confidence: 99%

“… Bischof et al (2022) inspected cord atrophy in a large legacy dataset of over 400 progressive pwMS with a 12-year follow-up, looking at C1 area in relation to disease progression trajectories, and showing that an accelerated atrophy rate in RRMS before conversion to secondary progressive (SP) disease. Freund et al (2022) used the BSC-SPM framework (see ‘Analysis tools’ section) to perform voxel-based morphometry (VBM) in the brain and CSC of pwMS and controls, showing feasibility of a unified analysis pipeline for concurrent assessment of regional brain and cord atrophy on T 1 -weighted MPRAGE images using a template extending to the upper CSC.…”

Section: Avenues For Future Researchmentioning

confidence: 99%

“… Forodighasemabadi et al (2021) developed a combined brain and whole cervical MP2RAGE acquisition with sub-millimeter resolution in <8 min, with particular attention to mitigating B 1 + inhomogeneity, enabling anatomical and segmentation and quantification of T 1 in the main CSC WM tracts as well as brain regions of interest with high scan-rescan reproducibility. Finally, with regards to data processing, the SPM-BSC currently only includes the upper four cervical levels, although future extension to the whole CSC is planned ( Freund et al, 2022 ). The presently available PAM50 template is also compatible with the MNI coordinate system, awaiting further applications in simultaneous or concurrent brain/cord imaging.…”

Section: Avenues For Future Researchmentioning

confidence: 99%

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Advanced spinal cord MRI in multiple sclerosis: Current techniques and future directions

Combes

Clarke

O’Grady

et al. 2022

NeuroImage: Clinical

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Feasibility of interleaved multislice averaged magnetization inversion‐recovery acquisitions of the spinal cord

Weigel,

Celicanin,

Haas

et al. 2024

Magnetic Resonance in Med

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PurposeTo establish an interleaved multislice variant of the averaged magnetization inversion‐recovery acquisitions (AMIRA) approach for 2D spinal cord imaging with increased acquisition efficiency compared with the conventional 2D single‐slice approach(es), and to determine essential prerequisites for a working interleaved multislice AMIRA approach in practice.MethodsThe general AMIRA concept is based on an inversion recovery–prepared, segmented, and time‐limited cine balanced SSFP sequence, generating images of different contrast. For AMIRA imaging of multiple, independent slices in a 2D interleaved fashion, a slice loop within the acquisition loops was programmed. The former non‐selective inversions were replaced with slice‐selective inversions with user‐definable slice thickness.ResultsThe thickness of the slice‐selective inversion in 2D interleaved multislice AMIRA should be doubled compared with the manufacturer's standard setting to avoid an increased sensitivity to flow and pulsation effects particularly in the CSF. However, this solution also limits its practical applicability, as slices located at directly adjacent vertebrae cannot be imaged together. Successful interleaved two‐slice AMIRA imaging for a “reference” in vivo protocol with 0.50 × 0.50 mm2 in‐plane resolution and 8‐mm slice thickness is demonstrated, therefore halving its acquisition time per slice from 3 min down to 1.5 min.ConclusionThe investigated 2D interleaved two‐slice AMIRA variant facilitates spinal cord imaging that maintains similar contrast and the same resolution as the conventional 2D single‐slice AMIRA approach, but does so with a halved acquisition time.

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Simultaneous assessment of regional distributions of atrophy across the neuraxis in MS patients

Cited by 9 publications

References 44 publications

Assessing the Equivalence of Brain-Derived Measures from Two 3D T1-Weighted Acquisitions: One Covering the Brain and One Covering the Brain and Spinal Cord

Assessing the Equivalence of Brain-Derived Measures from Two 3D T1-Weighted Acquisitions: One Covering the Brain and One Covering the Brain and Spinal Cord

Advanced spinal cord MRI in multiple sclerosis: Current techniques and future directions

Feasibility of interleaved multislice averaged magnetization inversion‐recovery acquisitions of the spinal cord

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