Simultaneous Application of Photothermal Therapy and an Anti‐inflammatory Prodrug using Pyrene–Aspirin‐Loaded Gold Nanorod Graphitic Nanocapsules

Dong, Qian; Wang, Xuewei; Hu, Xiaoxiao; Xiao, Langqiu; Zhang, Liang; Song, Lijuan; Xu, Minglu; Zou, Yuxiu; Chen, Long; Chen, Zhuo; Tan, Weihong

doi:10.1002/ange.201709648

Cited by 43 publications

(30 citation statements)

References 28 publications

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“…We chose to supplement PTT because the heat generation in the tumor tissue could naturally create an acute inflammatory environment for the recruitment of neutrophils with our NPNs from the blood circulation 26 . In addition, PTT is known to suffer from tumor recurrence due to the incomplete eradication of microtumors by the shallow light penetration depth in the tumor tissue 27 . It is therefore of great importance to develop combinatorial therapeutic methods to supplement the PTT efficacy.…”

mentioning

confidence: 99%

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

et al. 2020

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The efficacy of nano-mediated drug delivery has been impeded by multiple biological barriers such as the mononuclear phagocyte system (MPS), as well as vascular and interstitial barriers. To overcome the abovementioned obstacles, we report a nano-pathogenoid (NPN) system that can in situ hitchhike circulating neutrophils and supplement photothermal therapy (PTT). Cloaked with bacteria-secreted outer membrane vesicles inheriting pathogenassociated molecular patterns of native bacteria, NPNs are effectively recognized and internalized by neutrophils. The neutrophils migrate towards inflamed tumors, extravasate across the blood vessels, and penetrate through the tumors. Then NPNs are rapidly released from neutrophils in response to inflammatory stimuli and subsequently taken up by tumor cells to exert anticancer effects. Strikingly, due to the excellent targeting efficacy, cisplatinloaded NPNs combined with PTT completely eradicate tumors in all treated mice. Such a nano-platform represents an efficient and generalizable strategy towards in situ cell hitchhiking as well as enhanced tumor targeted delivery.

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confidence: 99%

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

et al. 2020

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“…Moreover, aspirin synergistically sensitizes osteosarcoma cells to cisplatin and radiotherapy . Combination of photo‐thermal therapy and aspirin has promising anticancer effects . Randomized clinical trials are necessary to evaluate the efficiency of combined cancer therapy including aspirin, molecular targeted therapy, chemotherapy, and radiotherapy.…”

Section: Aspirin Use For Cancer Therapymentioning

confidence: 99%

“…Notably, the aspirin‐like molecule o‐(acetoxyphenyl)hept‐2‐ynyl sulfide inhibits COX2 much more potently and selectively than aspirin . In addition to the above‐described derivatives of aspirin, an alternative strategy is to incorporate aspirin into nanoparticles . It warrants further studies to test the efficacy of these novel aspirin derivatives in clinical setting.…”

Section: Novel Derivatives Of Aspirinmentioning

confidence: 99%

Complex roles of the old drug aspirin in cancer chemoprevention and therapy

Hua

Zhang

Kong

et al. 2018

Medicinal Research Reviews

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The nonsteroidal anti-inflammatory agent aspirin is widely used for preventing and treating cardiovascular and cerebrovascular diseases. In addition, epidemiologic evidences reveal that aspirin may prevent a variety of human cancers, while data on the association between aspirin and some kinds of cancer are conflicting. Preclinical studies and clinical trials also reveal the therapeutic effect of aspirin on cancer. Although cyclooxygenase is a well-known target of aspirin, recent studies uncover other targets of aspirin and its metabolites, such as AMP-activated protein kinase, cyclin-dependent kinase, heparanase, and histone. Accumulating evidence demonstrate that aspirin may act in different cell types, such as epithelial cell, tumor cell, endothelial cell, platelet, and immune cell. Therefore, aspirin acts on diverse hallmarks of cancer, such as sustained tumor growth, metastasis, angiogenesis, inflammation, and immune evasion. In this review, we focus on recent progress in the use of aspirin for cancer chemoprevention and therapy, and integratively analyze the mechanisms underlying the anticancer effects of aspirin and its metabolites. We also discuss mechanisms of aspirin resistance and describe some derivatives of aspirin, which aim to overcome the adverse effects of aspirin.

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“…Based on this strategy, anti-in ammatory prodrug pyrene-aspirin loaded on gold nanorod-encapsulated graphitic nanocapsule was constructed to achieve photothermal ablation of tumor and simultaneously alleviate PTT-triggered in ammation. [12] This photothermal-antiin ammatory strategy overcomes the key shortcoming of traditional PTT (the trigger of proin ammatory cytokines during PTT). Alternatively, aiming at weakening the in ammatory response during PTT, a CO nanogenerator was constructed with partially oxidized in disul de nanosheets, tumor targeting polymer (PEG-cRGD), and chemotherapeutic drug doxorubicin.…”

Section: Introductionmentioning

confidence: 99%

Self-Synergistic Effect of Prussian Blue Nanoparticles for Cancer Therapy: Driving Photothermal Therapy and Reducing Hyperthermia-induced Side Effects

Xie

Gao

Hao

et al. 2021

Preprint

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BackgroundsPhotothermal therapy (PTT) inducing localized hyperthermia to kill cancer cells has attracted wide attention in cancer therapy. The production of reactive oxygen species (ROS) during photothermal therapy (PTT) may cause irreversible damage to healthy tissues around the tumor. Simultaneously, hyperthermia can stimulate inflammatory response, thus promoting tumor recurrence and metastasis. How to reduce the undesired side effects remains to be an inevitable problem for the further development of photothermal therapy.ResultsThe spherical mesoporous PBs with uniform size was prepared by an effective hydrothermal method. The yielded PBs exhibits good dispersion and stability in saline with an average hydrodynamic size of about 110 nm. The prepared PBs has a high photothermal conversion efficiency and photothermal stability. Meanwhile, PBs shows the intrinsic ROS scavenging properties (•OH, •OOH, and H2O2) in vitro. The antioxidant and anti-inflammatory effects of PBs have also been evaluated in vivo. Moreover, the toxicity assessment and endoplasmic reticulum (ER) stress-inducing ability show that PBs could not induce an inflammatory response. H&E-staining tissue of major organs show no significant damage, indicating that the good biocompatibility and safety of PBs in vivo. These intrinsic functions of PBs may achieve efficient PTT and simultaneously reduce the side effects induced by PTT.ConclusionThe designed single-component PBs with intrinsic properties simultaneously drive their photothermal-antioxidant effect and photothermal-anti-inflammatory effect to overcome the problem of inflammatory response and heat stress-induced ROS during PTT. The discovery of the inherent function of PBs not only promotes the further clinical translation of PBs, but also promotes the further development of PTT.

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Simultaneous Application of Photothermal Therapy and an Anti‐inflammatory Prodrug using Pyrene–Aspirin‐Loaded Gold Nanorod Graphitic Nanocapsules

Cited by 43 publications

References 28 publications

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

Complex roles of the old drug aspirin in cancer chemoprevention and therapy

Self-Synergistic Effect of Prussian Blue Nanoparticles for Cancer Therapy: Driving Photothermal Therapy and Reducing Hyperthermia-induced Side Effects

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