Simultaneous appearance of mycosis fungoides and chronic lymphocytic leukemia in the same patient

Konstantopoulos, K; Kapsimalis,; Vaiopoulos, George; Kokkinis, Constantinos; Papadaki, Theodora; Psarra, Katherina; J, Ekonomidou

doi:10.1163/15685590051129878

Cited by 10 publications

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“…The coexistence in the same patient of mycosis fungoides, a peripheral T‐cell lymphoma, and B or plasma cell malignancies (B‐cell malignancies) is unusual. Most reports are case reports, and the largest series comprises only six patients 3–29 Table 3. summarizes the 36 previous cases reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Mycosis fungoides associated with B-cell malignancies

Barzilai

Trau

David

et al. 2006

British Journal of Dermatology

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This case series indicates that while the coexistence of Hodgkin's lymphoma and mycosis fungoides is extremely rare, the association of mycosis fungoides and B-cell malignancies is not as rare as reflected in the literature, with non-Hodgkin's lymphoma constituting the most common associated B-cell malignancy. In this series as well as in the cases reported in the literature mycosis fungoides usually preceded the development of B-cell malignancies, which may be in accordance with previous reports of an increased risk of developing a second haematological neoplasm. The importance of a competent immune system for patients with mycosis fungoides is well demonstrated in these cases. It is suggested that for greater precision the criteria for diagnosis of composite lymphoma of the skin should include both phenotypic and genotypic features.

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Section: Discussionmentioning

confidence: 99%

Mycosis fungoides associated with B-cell malignancies

Barzilai

Trau

David

et al. 2006

British Journal of Dermatology

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“…Of the 47 cases reported to that time, 18 (38%) had CLL, and we have summarized the clinical features of these cases plus 8 additional cases in table 1[13,14,15,16,18,19,20,21,22,23,24,25,26,27,28,29,30,31]. It should be noted that 3 cases from the literature had skin lesions that were clinically atypical for CTCL.…”

Section: Discussionmentioning

confidence: 99%

Sézary Syndrome Coexisting with B-Cell Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

et al. 2007

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Introduction: The simultaneous presentation of chronic B-cell lymphocytic leukemia (B-CLL) and cutaneous T-cell lymphoma (CTCL) is extremely rare. Case Report: We describe a patient with B-CLL and Sézary syndrome (SS), an erythrodermic and leukemic variant of CTCL. Despite treatment, the SS progressed to involve internal organs and eventual death of the patient from sepsis. This is the first reported case of SS coexisting with chronic lymphocytic leukemia in which an anti-Vβ13.6 antibody was used to serially track changes in circulating neoplastic T cells vis-à-vis neoplastic B cells and to detect neoplastic T cells in ascitic fluid near the end of the patient’s life. Discussion: We speculate that the coexistence of B-CLL and CTCL is the result of an initiating genetic or epigenetic defect at the level of the common lymphoid stem cell that predisposes both B-cell and T-cell lineages to additional oncogenic changes at a more advanced stage of differentiation.

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“…An association between CTCL and CLL has been described in prior reports. [6][7][8][9][10][11][12][13][14][15][16][17][18] For decades, clinicians have surmised that secondary malignancy occurs more often in patients with lymphoproliferative disorders, specifically CLL. 5,[19][20][21][22][23][24] Cutaneous tumors have been shown not only to develop more fre-quently but also to behave more aggressively in patients with CLL.…”

Section: Introductionmentioning

confidence: 99%

CutaneousT‐cell lymphoma in patients with chronic lymphocytic leukemia: clinical characteristics, temporal relationships, and survival data in a series of 14 patients atMayoClinic

2013

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Simultaneous appearance of mycosis fungoides and chronic lymphocytic leukemia in the same patient

Abstract: A patient is presented having simultaneously chronic lymphocytic leukemia with a monoclonal B-lymphocyte population and mycosis fungoides with atypical T-cell population in the skin lesion and in the enlarged lymphoid nodes confirmed by detailed phenotyping.

Cited by 10 publications

References 0 publications

Mycosis fungoides associated with B-cell malignancies

Mycosis fungoides associated with B-cell malignancies

Sézary Syndrome Coexisting with B-Cell Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

CutaneousT‐cell lymphoma in patients with chronic lymphocytic leukemia: clinical characteristics, temporal relationships, and survival data in a series of 14 patients atMayoClinic

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