To develop a clinic ally available prosthesis base d on electromyography (EM G) signals, t he n umber of r ecording electrodes should be as small a s p ossible. In t his stud y, we investigate the po ssibility of th e least absolute s hrinkage and selection operator (LASSO) for finding electrode subsets suitable for regression based myoelectric prosthesis control. EMG signals were re corded using 192 electrodes while ten s ubjects were performing tw o degree-of-freedom (DoF ) wrist movem ents. Among the w hole c hannels, we s elected subsets consisting of 96, 64, 48, 32, 24, 16, 12, and 8 ele ctrodes, respectively, u sing the LASSO metho d. As a baseline method, electrode subset s ha ving the same numbers of electrodes w ere a rbitrary s elected w ith regular spacing (uniform selection method). The performance of decoding the movements was estimated using the r-square value. The e lectrode su bsets s elected b y the LAS SO met hod g enerally outperformed those chosen by the arbitrary selection method. In particular, th e performance of th e LA SSO method was significantly higher th an that of the a rbitrary selection me thod when using the subsets of 8 e lectrodes. From the analysis results, we could confir m that the LASSO method can b e us ed to s elect reasonable el ectrode subsets for reg ression b ased m yoelectric prosthesis control.Keywords-electromyography ( EMG); my oelectric control; prosthetic hand; regression; least absolute shrinkage and selection operator (LASSO)