Simultaneous analysis of the H1-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride by high-performance liquid chromatography

Quantification of antihistamine acrivastine in plasma by solid-phase extraction and high-performance liquid chromatography

“…The HPLC assay was modified from a previous assay method for simultaneous determination of acrivastine and pseudoephedrine developed in our laboratory [14]. Briefly, the Waters ® component system (Milford, MA, USA) was comprised of a 600 S Controller, a 616 Solvent Delivery Pump, a 717 Autosampler, a 996 Photodiode Array Detector, and a C 18 Nova-Pak ® column (4 m, 3.9 mm × 150 mm).…”

“…These included derivative spectrophotometry [8], high-performance liquid chromatography with ultraviolet detection (HPLC-UV) [9], gas chromatography with mass spectrometric detection (GC-MS) [10,11], radioimmunoassay [12], and electrochemical measurement [13]. We have recently reported an HPLC-UV method to simultaneously analyze acrivastine and pseudoephedrine hydrochloride in Semprex ® -D capsules [14]. The assay was found to be accurate, specific, selective, rapid and versatile for use in routine quality control of acrivastine and pseudoephedrine preparations.…”

Chromatographic separation and spectroscopic characterization of the e/z isomers of acrivastine

“…A literature review revealed that Acrivastine has been determined and studied by several procedures; gas chromatography mass‐spectrometric analysis,3 a sensitive radioimunoassay to measure plasma levels,4 nondirect spectrofluorimetric method5 and several spectrophotometric procedures to measure acrivastine in urine and pharmaceuticals 5–8. The high performance liquid chromatography (HPLC) methods have also been reported for the determination of acrivastine in capsules using ultraviolet detection 8, 9. There are reports for the determination of the Acrivastine in human urine and pharmaceutical by spectroflourimetric method10 and by electrochemical method 11…”

Isolation, structure elucidation, and high‐performance liquid chromatography quantification of photolytic degradation impurities in acrivastine

“…Previous studies mainly focused on the quantitative determination of acrivastine in biosamples using spectroscopy [11], GC–MS [12], SPE–HPLC [13], HPLC–MS [14], and electrochemical methods [15]; the quantitative determination of acrivastine formulation using HPLC with monolithic stationary phase [16]; simultaneous analysis of acrivastine and pseudoephedrine hydrochloride by HPLC [16, 17]. Recently, the Z ‐isomer of acrivastine has been isolated and structurally elucidated using HPLC [18].…”