Objective
Acetamiprid (ACP) causes infertility and its effect appears to occur via
oxidative stress. Melatonin has antioxidative properties. Thus, in this
experimental study, we examined the protective effect of melatonin against
toxic pathologic changes from ACP on reproductive system parameters of
female mice.
Methods
The study included 30 female mice divided into 5 groups (6 mice in each
group), as follows: Saline (control group); ACP (10, 20 mg/kg); ACP
(10mg/kg) + melatonin (10mg/kg); and ACP (20mg/kg) + melatonin (10mg/kg).
All mice were given intraperitoneal injections daily for one month. The
groups were evaluated for ovarian histopathological changes and oocyte
quality based on in vitro fertilization (IVF) parameters.
Results
ACP induced histological damages in the ovaries of mice and caused increases
in the number of atretic follicles and decreases in the quality of oocytes
based on IVF parameters. These alterations were significantly reduced by
melatonin.
Conclusions
Melatonin can decrease the toxic effects of ACP in the female reproductive
system of mice. Further studies are needed.