Simultaneous administration of mifepristone and misoprostol for early termination of pregnancy: a randomized controlled trial

Goel, Anupama; Mittal, Shilekh; Taneja, Bal Krishan; Singal, Neerja; Attri, Shivani

doi:10.1007/s00404-011-1881-2

Cited by 18 publications

(34 citation statements)

References 20 publications

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“…[7][8][9][10][11][12] Overall it has been shown that an interval of approximately 6 hours between mifepristone and misoprostol results in equal efficacy as 24-48 hours in first-trimester abortion. There have been several studies specifically assessing the interval between mifepristone and misoprostol administration with respect to abortion outcome.…”

Section: Methods Of Study Selectionmentioning

confidence: 99%

Mifepristone–Misoprostol Dosing Interval and Effect on Induction Abortion Times

Shaw

Topp

Shaw

et al. 2013

Obstetrics &Amp; Gynecology

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Section: Methods Of Study Selectionmentioning

confidence: 99%

Mifepristone–Misoprostol Dosing Interval and Effect on Induction Abortion Times

Shaw

Topp

Shaw

et al. 2013

Obstetrics &Amp; Gynecology

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“…There may be little to no difference in rates of successful abortion between concurrent administration of misoprostol and a 24-hour interval (RR 1.01 CI 95% 0.84-1.21, very low certainty of evidence) [23,24]. There was no signi cant difference between 24-hour and 48-hour interval in terms of ongoing pregnancy and successful abortion [10,21,22].…”

Section: Comparison Of Dosing Intervals Between Mifepristone and Misomentioning

confidence: 99%

“…Eight studies assessed different time intervals between mifepristone and misoprostol dosing in the combined regimen. These include comparisons between < 8 hours vs. > 24 hours [8,9], 24 hours vs. 48 hours [10,21,22], concurrent administration vs. 24 hours [23,24] and < 8 hours vs. 48 hours [25] (Table 2).…”

Section: Comparison Of Dosing Intervals Between Mifepristone and Misomentioning

confidence: 99%

Medical termination for pregnancy in early first trimester (≤ 63 days) using combination of mifepristone and misoprostol or misoprostol alone: a systematic review

Abubeker

Lavelanet

Rodríguez

et al. 2020

Preprint

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Background: A wide range of drugs have been studied for first trimester medical abortion. Studies evaluating different regimens, including combination mifepristone and misoprostol and misoprostol alone regimens, show varying results related to safety, efficacy and other outcomes.Objectives: To compare the safety, effectiveness and acceptability of medical abortion and to compare medical methods with surgical methods of abortion ≤ 63 days of gestation. Methods: Pubmed and EMBASE were systematically searched from database inception through January 2019 using a combination of MeSH, keywords and text words. Randomized controlled trials on induced abortion at ≤ 63 days that compared different regimens of medical abortion using mifepristone and/or misoprostol and trials that compared medical with surgical methods of abortion were included. We extracted data into a pre‐designed form, calculated effect estimates, and performed meta‐analyses where possible. The primary outcomes were ongoing pregnancy and successful abortion. Results: Thirty-three studies composed of 22,275 participants were included in this review. Combined regimens using mifepristone and misoprostol had lower rates of ongoing pregnancy and higher rates of successful abortion compared to misoprostol only regimens. In combined regimens, misoprostol 800 μg was more effective than 400 μg. There was no significant difference in dosing intervals between mifepristone and misoprostol and routes of misoprostol administration in combination or misoprostol alone regimens. The rate of serious adverse events was generally low. Conclusion: In this systematic review, we find that medical methods of abortion utilizing combination mifepristone and misoprostol or misoprostol alone are effective, safe and acceptable. More robust studies evaluating both the different combination and misoprostol alone regimens are needed to strengthen existing evidence as well as assess patient perspectives towards a particular regimen.

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“…Ashok et al (1998) reported a success rate of 99.4% in 2000 women. Alternatives to the 48 hour interval are immediate with no interval, or a 24-36 hour interval; although the success rates for these are lower they are still in the high nineties (Goel et al, 2011). The highest success rates for stimulating expulsive uterine contractions are with the woman, after washing her hands and wetting the tablets with a quick dip in water, inserting the four misoprostol 200 mcg tablets vaginally.…”

Section: Induction With Mifepristone and Misoprostolmentioning

confidence: 99%