Simulations of enhanced malaria transmission and host bias induced by modified vector blood location behaviour

Pa, Rossignol; Am, Rossignol

doi:10.1017/s0031182000058789

Cited by 18 publications

(5 citation statements)

References 26 publications

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“…Hitherto, it is the influence of vector-parasite interactions on the values of the ratios L/L, a/a and a'/a" that have been the concern, implicitly or explicitly, of experimentalists (Table 1, column 4) and theoreticians (Anderson, 1981 ;Ribeiro, Rossignol & Spielman, 1985;Kingsolver, 1987;Dobson, 1988;Rossignol & Rossignol, 1988) alike. Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Considering the epidemiological significance of parasite-induced effects, both experimentalists (Table 1) and theoreticians (Anderson, 1981;Ribeiro, Rossignol & Spielman, 1985;Kingsolver, 1987;Dobson, 1988;Rossignol & Rossignol, 1988) have generally compared infected with uninfected vectors, and concluded that parasites either increase or decrease the rate of transmission. However, this is not the most relevant comparison in practical epidemiology because parasites are just one of a number of sources of measurement bias.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological significance of vector–parasite interactions

1990

Parasitology

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A great deal of published experimental evidence shows that parasite-induced changes in host choice, and biting and survival rates of bloodsucking insects are an important source of bias in estimates of Vectorial Capacity. I argue here that, because of the difficulties of handling these and other biases in practice, indices (based on the Vectorial Capacity) which purport to measure transmission rate are best used in a comparative rather than an absolute way. They should attempt to measure, not transmission rate, but changes in transmission rate. In this case, the less restrictive assumption that parasites are responsible for constant bias (rather than no bias) leads to relatively small errors. The results encourage a more optimistic view of the performance of classical entomological indices such as the parous rate. They should also help to redirect the principal epidemiological question about vector-parasite interactions: future studies should be concerned with the impact of parasites, not directly on Vectorial Capacity, but on the comparative measures which are actually used to evaluate transmission rate.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidemiological significance of vector–parasite interactions

1990

Parasitology

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“…One possible mechanism underlying these changes in feeding behavior is suggested by data demonstrating that salivary gland sporozoites decrease the level of apyrase in the mosquito host's saliva, making it more difficult for them to feed to repletion on one host [96,97]. It is predicted that such changes in feeding behavior would significantly increase the likelihood that a single infected mosquito transmits sporozoites [98,99].…”

Section: Does Plasmodium Manipulate Its Mosquito Host To Increase Transmission Likelihood?mentioning

confidence: 99%

When Is a Plasmodium-Infected Mosquito an Infectious Mosquito?

Graumans¹,

Jacobs

Bousema

et al. 2020

Trends in Parasitology

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The discrepancy between exposure to infected mosquito bites and malaria incidence suggests a transmission bottleneck that is currently understudied.Recent studies from non-human malaria models are indicative of a minimum salivary gland sporozoite density that is required to achieve infection following a mosquito bite.Infection-induced alterations in bloodfeeding behavior of mosquitoes may influence natural transmission dynamics.

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“…Anaplasma modulates the immune response of ticks, but it does not affect the feeding behaviour, which helps to maintain the vector capacity [93]. However, there is a need for more work to be done on feeding and other ticks' behaviours.…”

Section: Changes In Blood Feedingmentioning

confidence: 99%

Advances in Understanding Vector Behavioural Traits after Infection

2021

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Vector behavioural traits, such as fitness, host-seeking, and host-feeding, are key determinants of vectorial capacity, pathogen transmission, and epidemiology of the vector-borne disease. Several studies have shown that infection with pathogens can alter these behavioural traits of the arthropod vector. Here, we review relevant publications to assess how pathogens modulate the behaviour of mosquitoes and ticks, major vectors for human diseases. The research has shown that infection with pathogens alter the mosquito’s flight activity, mating, fecundity, host-seeking, blood-feeding, and adaptations to insecticide bed nets, and similarly modify the tick’s locomotion, questing heights, vertical and horizontal walks, tendency to overcome obstacles, and host-seeking ability. Although some of these behavioural changes may theoretically increase transmission potential of the pathogens, their effect on the disease epidemiology remains to be verified. This study will not only help in understanding virus–vector interactions but will also benefit in establishing role of these behavioural changes in improved epidemiological models and in devising new vector management strategies.

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Simulations of enhanced malaria transmission and host bias induced by modified vector blood location behaviour

Cited by 18 publications

References 26 publications

Epidemiological significance of vector–parasite interactions

Epidemiological significance of vector–parasite interactions

When Is a Plasmodium-Infected Mosquito an Infectious Mosquito?

Advances in Understanding Vector Behavioural Traits after Infection

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