Simulations and Velocity Measurements for a Microparticle in an Evanescent Field

Jaising, Hitesh; Grujić, Katarina; Tomita, Olav Gaute Helles⊘

doi:10.1007/s10043-005-0004-3

Cited by 10 publications

(13 citation statements)

References 9 publications

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“…The theoretical model was simulated by adapting the Arbitrary Beam Theory (ABT) developed by [4,5]. The simulation was made using the same model as in [6,7]. Unless stated otherwise, the waveguide parameters used in the simulation were a 4µm channel width, a substrate index of 1.50, a waveguide index of 1.54 and a particle index of 1.59 dispersed in water (index of 1.33).…”

Section: Methodsmentioning

confidence: 99%

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Biophotonics sensor acclimatization to stem cells environment

Shahimin

2017

EPJ Web Conf.

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Abstract. The ability to discriminate, characterise and purify biological cells from heterogeneous population of cells is fundamental to numerous prognosis and diagnosis applications; often forming the basis for current and emerging clinical protocols in stem cell therapy. Current sorting approaches exploit differences in cell density, specific immunologic targets, or receptor-ligand interactions to isolate particular cells. Identification of novel properties by which different cell types may be discerned and of new ways for their selective manipulation are clearly fundamental components for improving sorting methodologies. Biophotonics sensor developed by our team are potentially capable of discriminating cells according to their refractive index (which is highly dependable on the organelles inside the cell), size (indicator to cell stage) and shape (in certain cases as an indicator to cell type). The sensor, which already discriminate particles efficiently, is modified to acclimatize into biological environment, especially for stem cell applications.

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Section: Methodsmentioning

confidence: 99%

“…In order to understand the effect of different refractive indices of particles, a simulation using the same model as in [6,7] was carried out. The same optical and waveguide arrangement, as described earlier in this section, was set in the simulation.…”

Section: Refractive Index Variationmentioning

confidence: 99%

Biophotonics sensor acclimatization to stem cells environment

Shahimin

2017

EPJ Web Conf.

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“…To find the optical forces on a particle using the Maxwell-stress tensor, three-dimensional models are necessary. Mie theory can be used to simulate optical forces on spherical microparticles [16,17]. Rayleigh theory can be employed to simulate optical forces on nano-particles [12].…”

Section: Optical Waveguidesmentioning

confidence: 99%

“…The evanescent field surrounding an optical waveguide, however, can also be used for optical trapping [8][9][10][11][12][13][14][15][16][17][18][19]. The decay length of the evanescent field is within 250 nm from the waveguide surface [9,15].…”

Section: Introductionmentioning

confidence: 99%

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Optical trapping and propulsion of red blood cells on waveguide surfaces

et al. 2010

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Abstract:We have studied optical trapping and propulsion of red blood cells in the evanescent field of optical waveguides. Cell propulsion is found to be highly dependent on the biological medium and serum proteins the cells are submerged in. Waveguides made of tantalum pentoxide are shown to be efficient for cell propulsion. An optical propulsion velocity of up to 6 µm/s on a waveguide with a width of ~6 µm is reported. Stable optical trapping and propulsion of cells during transverse flow is also reported.

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Surface transport and stable trapping of particles and cells by an optical waveguide loop

et al. 2012

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Waveguide trapping has emerged as a useful technique for parallel and planar transport of particles and biological cells and can be integrated with lab-on-a-chip applications. However, particles trapped on waveguides are continuously propelled forward along the surface of the waveguide. This limits the practical usability of the waveguide trapping technique with other functions (e.g. analysis, imaging) that require particles to be stationary during diagnosis. In this paper, an optical waveguide loop with an intentional gap at the centre is proposed to hold propelled particles and cells. The waveguide acts as a conveyor belt to transport and deliver the particles/cells towards the gap. At the gap, the diverging light fields hold the particles at a fixed position. The proposed waveguide design is numerically studied and experimentally implemented. The optical forces on the particle at the gap are calculated using the finite element method. Experimentally, the method is used to transport and trap micro-particles and red blood cells at the gap with varying separations. The waveguides are only 180 nm thick and thus could be integrated with other functions on the chip, e.g. microfluidics or optical detection, to make an on-chip system for single cell analysis and to study the interaction between cells.

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Simulations and Velocity Measurements for a Microparticle in an Evanescent Field

Cited by 10 publications

References 9 publications

Biophotonics sensor acclimatization to stem cells environment

Biophotonics sensor acclimatization to stem cells environment

Optical trapping and propulsion of red blood cells on waveguide surfaces

Surface transport and stable trapping of particles and cells by an optical waveguide loop

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