2020
DOI: 10.1136/bmjopen-2020-037022
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Simulation study to demonstrate biases created by diagnostic criteria of mental illnesses: major depressive episodes, dysthymia, and manic episodes

Abstract: ObjectivesComposite diagnostic criteria alone are likely to create and introduce biases into diagnoses that subsequently have poor relationships with input symptoms. This study aims to understand the relationships between the diagnoses and the input symptoms, as well as the magnitudes of biases created by diagnostic criteria and introduced into the diagnoses of mental illnesses with large disease burdens (major depressive episodes, dysthymic disorder, and manic episodes).SettingsGeneral psychiatric care.Partic… Show more

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Cited by 11 publications
(61 citation statements)
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“…[25] Only weighted statistics were released[25], and they needed to meet a minimum sample size requirement. [26][27][28][29][30] To protect participant confidentiality and prevent participants from being identified using the released data, Statistics Canada did not allow the release of calculated proportions based on 10 or fewer unweighted participants. At least one participant in each sampling site for each cycle was required.…”
Section: Discussionmentioning
confidence: 99%
“…[25] Only weighted statistics were released[25], and they needed to meet a minimum sample size requirement. [26][27][28][29][30] To protect participant confidentiality and prevent participants from being identified using the released data, Statistics Canada did not allow the release of calculated proportions based on 10 or fewer unweighted participants. At least one participant in each sampling site for each cycle was required.…”
Section: Discussionmentioning
confidence: 99%
“…The correlations between the disease and the other associated disease were 0, 0.3, and 0.7. We assumed the prevalence rates of the disease were 0.05, 0.1, 0.2, 0.4, and 0.8, similar to the values adopted in a previous study 2 . Several conditions have been observed in more than 80% of selected populations, for example, Epstein–Barr virus infection 12 , 13 and the herpes simplex virus type 2 infection 14 .…”
Section: Methodsmentioning
confidence: 99%
“…Symptoms that are considered signs of certain diseases have been used for diagnostic purposes such as those used for the diagnosis of frailty and mental illnesses 1 , 2 . The diagnostic accuracy of these symptoms varies over a wide range 3 .…”
Section: Introductionmentioning
confidence: 99%
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“…However, there are issues related to the use of composite measures or indices, such as frailty indices and three diagnoses of mental illnesses in clinical trials ( 1 , 14 ). One of the critical issues is interpretability.…”
Section: Introductionmentioning
confidence: 99%