Simulation study on the mass transport in PCL based on the ciliated dynamic system of the respiratory tract

Zhu, Pengfei; Chen, Duanduan; Xu, Yuanqing

doi:10.1088/1742-6596/1300/1/012068

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…In the literature, both 2D and 3D CFD models are employed to estimate the flow due to the cilia motion [ 51 , 73 , 74 ]. In our study, the cilia were modeled as membranes with indiscernible thickness.…”

Section: Methodsmentioning

confidence: 99%

Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo

2022

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Motile cilia are hair-like microscopic structures which generate directional flow to provide fluid transport in various biological processes. Ciliary beating is one of the sources of cerebrospinal flow (CSF) in brain ventricles. In this study, we investigated how the tilt angle, quantity, and phase relationship of cilia affect CSF flow patterns in the brain ventricles of zebrafish embryos. For this purpose, two-dimensional computational fluid dynamics (CFD) simulations are performed to determine the flow fields generated by the motile cilia. The cilia are modeled as thin membranes with prescribed motions. The cilia motions were obtained from a two-day post-fertilization zebrafish embryo previously imaged via light sheet fluorescence microscopy. We observed that the cilium angle significantly alters the generated flow velocity and mass flow rates. As the cilium angle gets closer to the wall, higher flow velocities are observed. Phase difference between two adjacent beating cilia also affects the flow field as the cilia with no phase difference produce significantly lower mass flow rates. In conclusion, our simulations revealed that the most efficient method for cilia-driven fluid transport relies on the alignment of multiple cilia beating with a phase difference, which is also observed in vivo in the developing zebrafish brain.

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Section: Methodsmentioning

confidence: 99%

Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo

2022

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“…Mathematical models used to calculate the velocity in the free-fluid region and the porous medium are numerous [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

On the Asymptotic Boundary Condition at the Free-Fluid/Porous-Medium Interface in Periciliary Layer due to the Ciliary Movement

Poopra

Wuttanachamsri

2022

Mathematical Problems in Engineering

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The purpose of this study is to study the movement of the periciliary (PCL) fluid due to the ciliary locomotion. In this research, because the bundle of cilia is considered instead of a single cilium, Stokes–Brinkman equations in a macroscopic scale are employed to find the velocity of the PCL fluid. When the cilia are perpendicular to the horizontal plane, the PCL consists of only the cilia. The inclination of cilia (cilia make an angle θ θ < 90 ∘ to the horizontal plane) results in two different domains in the PCL, the regions comprising and not comprising cilia. The main objective of this study is to determine the appropriate boundary conditions of the velocity between these two regions where the PCL fluid is moved by self-propelled cilia rather than the pressure gradient. A matched asymptotic expansion method is applied to the Stokes–Brinkman equations to determine the constraints. Two boundary conditions at the interface are obtained and the velocity of the PCL fluid at the top of PCL can be used to be the boundary conditions at the bottom of the mucus layer to determine the velocity of mucus. This model can help engineers to build devices to treat patients who have problem with the respiratory system. Applications include modeling fluid flow through filters such as engine filter and rice fields.

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Simulation study on the mass transport in PCL based on the ciliated dynamic system of the respiratory tract

Cited by 2 publications

References 18 publications

Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo

Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo

On the Asymptotic Boundary Condition at the Free-Fluid/Porous-Medium Interface in Periciliary Layer due to the Ciliary Movement

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