This paper proposes an efficient hybrid analytical-computational approach for the simulation of mechanical vibrations and sound radiation in wind turbine drive trains.The computational procedure encompasses the detailed modeling of vibrational sources and structural sound paths as well as the major panels of airborne noise radiation. The angle-varying mesh stiffness is obtained from a series of quasi-static finite element simulations. A novel procedure is proposed to obtain the time-varying mesh stiffness at fluctuating speed. The varying mesh stiffness is introduced as a parametric excitation in an analytical gear model, and the Fourier-transformed results are used as vibrational sources in a finite-element-based harmonic response analysis of the drive train. The present paper focuses on the modeling of gear contact and gearbox vibrations. The models and procedures are outlined, and computational results are compared to physical measurements on a 2.5 MW wind turbine. The results are in good qualitative agreement at tonal frequencies. This is particularly the case at fluctuating speed, where both the simulation and the measurement show the characteristic effect of frequency modulation. The computational procedure has been expanded to the whole drive train and is effectively applied in the conception and evaluation of design measures for the reduction of tonal amplitudes.