Simulation of ultrasoft X-rays induced DNA damage using the Geant4 Monte Carlo toolkit

Calculation of direct effects of 60Co gamma rays on the different DNA structural levels: A simulation study using the Geant4-DNA toolkit

“…Also, by using the Geant4-DNA extension, the Geant4 toolkit can be utilized for simulation of early biological damage induced by ionizing radiation at micrometric and nanometric scale such as DNA [28,29]. Capability of the Geant4-DNA in microdosimetry and nanodosimetry fields has been investigated in some previous studies [30][31][32][33][34][35].…”

Study on the dose enhancement of gold nanoparticles when exposed to clinical electron, proton, and alpha particle beams by means of Geant4

“…The liquid water is considered a cytoplasm and nucleus material, which is a more realistic estimation of the biological matter. [ 5 18 ] Confocal images obtained from cell population in the experimental studies clarify that NPs are generally placed around the cell nucleus but do not enter it. [ 7 16 ] Therefore, they were arranged in an orderly manner in the cytoplasm in the vicinity of the nucleus [ Figure 1b ].…”

“…Damaging DNA means stopping the growth of cancerous cell or cell kill. [ 17 18 ] It is assumed that DNA is hurt through single-strand break (SSB), double-strand break (DSB), and base damage due to ionizing radiation in the cellular DNA. [ 2 18 ] In this study, the amount of SSBs and DSBs in the presence of GNPs in the irradiated cells with electron beams is calculated using the Geant4-DNA toolkit.…”

Review of Geant4-DNA applications for micro and nanoscale simulations

“…This cylindrical approach was also followed by Semsarha and colleagues for the prediction of DNA damage in a variety of studies: from Auger emitter radionuclides ( 123 I and 125 I) [54], from 60 Co gamma rays [55,56] and from ultrasoft X-rays [57].…”

“…For example, in the previously described study of Tajik et al [57] the total yields of SSB and DSB induced by monoenergetic electrons with energies of 0.28-4.55 keV, corresponding to ultrasoft X-rays energies, have been modelled in the Charlton and Humm volume model using the Geant4-DNA toolkit. They observed that in the low energy region, the yield of SSBs remained fairly constant while the yield of DSBs increased with decreasing energy.…”