Simulation of stent deployment in a realistic human coronary artery

Gijsen, Frank; Migliavacca, Francesco; Schievano, Silvia; Socci, Laura; Petrini, Lorenza; Thury, Attila; Wentzel, Jolanda J.; Steen, A.F.W. van der; Serruys, Patrick W.; Dubini, Gabriele

doi:10.1186/1475-925x-7-23

Cited by 109 publications

(79 citation statements)

References 33 publications

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“…These computational methods of analysis employ sophisticated numerical techniques, such as the finite element and finite volume methods, to obtain approximate numerical solutions to complex physical problems. To date, a large number of studies have carried out computational structural (CS) analyses 1,4,5,14,15,19,[25][26][27][28][29]37,44,53,54,57,59,[62][63][64]72,73,78,80,85,87,[90][91][92] and computational fluid dynamics (CFD) analyses 3,8,9,12,30,31,33,42,[47][48][49][50][51]65,66,69,[74][75][76]83,89 ...…”

Section: Introductionmentioning

confidence: 99%

Sequential Structural and Fluid Dynamics Analysis of Balloon-Expandable Coronary Stents: A Multivariable Statistical Analysis

Martín¹,

Boyle²

2015

Cardiovasc Eng Tech

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Abstract-Several clinical studies have identified a strong correlation between neointimal hyperplasia following coronary stent deployment and both stent-induced arterial injury and altered vessel hemodynamics. As such, the sequential structural and fluid dynamics analysis of balloon-expandable stent deployment should provide a comprehensive indication of stent performance. Despite this observation, very few numerical studies of balloon-expandable coronary stents have considered both the mechanical and hemodynamic impact of stent deployment. Furthermore, in the few studies that have considered both phenomena, only a small number of stents have been considered. In this study, a sequential structural and fluid dynamics analysis methodology was employed to compare both the mechanical and hemodynamic impact of six balloon-expandable coronary stents. To investigate the relationship between stent design and performance, several common stent design properties were then identified and the dependence between these properties and both the mechanical and hemodynamic variables of interest was evaluated using statistical measures of correlation. Following the completion of the numerical analyses, stent strut thickness was identified as the only common design property that demonstrated a strong dependence with either the mean equivalent stress predicted in the artery wall or the mean relative residence time predicted on the luminal surface of the artery. These results corroborate the findings of the large-scale ISAR-STEREO clinical studies and highlight the crucial role of strut thickness in coronary stent design. The sequential structural and fluid dynamics analysis methodology and the multivariable statistical treatment of the results described in this study should prove useful in the design of future balloon-expandable coronary stents.

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Section: Introductionmentioning

confidence: 99%

Sequential Structural and Fluid Dynamics Analysis of Balloon-Expandable Coronary Stents: A Multivariable Statistical Analysis

Martín¹,

Boyle²

2015

Cardiovasc Eng Tech

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“…In this regard, Finite element (FE) analysis could be used to study the mechanical behaviour of stents and their interaction with the vascular wall during its deployment. Actually, while an extensive application of FE modelling for simulating the treatment of vessel stenoses can be found in the literature (Migliavacca et al 2004;Wu et al 2007;De Beule et al 2008;Gijsen et al 2008;Early et al 2009;Mortier et al 2010), to date the amount of similar studies on cerebral aneurysm treatment has been very limited. In fact, the Finite Element method (FEM) allows very complex models to be developed, including high non-linearity due to material properties (for instance, Holzapfel et al 2005, for the biomechanics of coronary arteries, and Petrini et al 2005, for the material properties of the stent) and kinematics, which facilitate accurate description of the stenting procedure.…”

Section: Introductionmentioning

confidence: 99%

Deployment of self-expandable stents in aneurysmatic cerebral vessels: comparison of different computational approaches for interventional planning

Bernardini

Larrabide

Petrini

et al. 2012

Computer Methods in Biomechanics and Biomedical Engineering

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JOB NUMBER: 527838 JOURNAL: GCMB Q1 Please check the affiliation details 'a and c'. Q2The reference citation 'Appanaboyina et al. (2007)' has been changed to 'Appanaboyina et al. (2008)' as per the reference list. Please check and confirm. Q3We have made a change to this sentence. Please review our edit.Q4 Please confirm our edit of the word 'modulus' to 'ratio' in this sentence. In the last few years, there has been a growing focus on faster computational methods to support clinicians in planning stenting procedures. This study investigates the possibility of introducing computational approximations in modelling stent deployment in aneurysmatic cerebral vessels to achieve simulations compatible with the constraints of real clinical workflows. The release of a self-expandable stent in a simplified aneurysmatic vessel was modelled in four different initial positions. Six progressively simplified modelling approaches (based on Finite Element method and Fast Virtual Stenting -FVS) have been used. Comparing accuracy of the results, the final configuration of the stent is more affected by neglecting mechanical properties of materials (FVS) than by adopting 1D instead of 3D stent models. Nevertheless, the differences showed are acceptable compared to those achieved by considering different stent initial positions. Regarding computational costs, simulations involving 1D stent features are the only ones feasible in clinical context.

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“…There are only a few studies that have utilized patient-specific derived arterial geometries in the analysis of stent [21]- [23]. The methodology using patient-specific artery model has the potential to provide a scientific basis for optimizing stenting treatment procedures.…”

Section: Resultsmentioning

confidence: 99%

Computational Fluid Dynamic Analysis of Coronary Artery Stenting

Gao¹,

Li²,

Hu³

et al. 2014

IJBBB

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Abstract-Coronary artery disease is the most prevalent form of cardiovascular disease and is the largest subset of this mortality. Stent implantation becomes a common interventional procedure for treatment of coronary artery disease. In this study, fluid dynamics factors in patient specific three dimensional coronary artery models before and after stenting were studied. The three dimensional models of the coronary artery were constructed from CT image of the patient. Commercial software Adina was used for computational fluid dynamics simulation. The wall shear stress and blood velocity were greater at the region of stenosis before stenting. The fluid dynamics values have come back near to normal values in the coronary artery model fitted with stent. The technique can be employed to estimate the relevant quantities and to optimize the design of intravascular stents.

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Simulation of stent deployment in a realistic human coronary artery

Cited by 109 publications

References 33 publications

Sequential Structural and Fluid Dynamics Analysis of Balloon-Expandable Coronary Stents: A Multivariable Statistical Analysis

Sequential Structural and Fluid Dynamics Analysis of Balloon-Expandable Coronary Stents: A Multivariable Statistical Analysis

Deployment of self-expandable stents in aneurysmatic cerebral vessels: comparison of different computational approaches for interventional planning

Computational Fluid Dynamic Analysis of Coronary Artery Stenting

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